Gene: Kdm8

Order

Name lysine (K)-specific demethylase 8

Synonyms
  • Jmjd5
  • 3110005O21Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1924285    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal     Homozygous - Subviable

Phenotype associations for Kdm8

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Kdm8 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Kdm8tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, incomplete penetrance Kdm8tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased body weight Kdm8tm1a(EUCOMM)Wtsi HET Female Male postnatal 1.01E-7
abnormal response to tactile stimuli Kdm8tm1a(EUCOMM)Wtsi HET Female postnatal 1.86E-7
increased circulating potassium level Kdm8tm1a(EUCOMM)Wtsi HET Female postnatal 4.45E-7
abnormal glucose homeostasis Kdm8tm1a(EUCOMM)Wtsi HET Male postnatal 2.18E-6
increased circulating HDL cholesterol level Kdm8tm1b(EUCOMM)Wtsi HET Male postnatal 1.44E-5
abnormal iris pigmentation Kdm8tm1a(EUCOMM)Wtsi HET Male postnatal 2.79E-5
increased B cell number Kdm8tm1a(EUCOMM)Wtsi HET Female Male postnatal 8.24E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415)
Aorta 4 No
Bone 4 No
Brain 4 No (4/4)
Brainstem 4 No (4/4)
Brown adipose tissue 4 No
Cartilage tissue 4 No (4/4)
Cerebellum 4 No (4/4)
Cerebral cortex 4 No (4/4)
Esophagus 4 No (7/415)
Eye 4 No
Gall bladder 4 No
Heart 4 No
Hippocampus 4 No (4/4)
Hypothalamus 4 No (4/4)
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Olfactory lobe 4 No (3/4)
Oral epithelium 4 No
Ovary 4 No (1/584)
Oviduct 4 No
Pancreas 4 No (5/584)
Parathyroid gland 4 No
Peripheral nervous system 4 No (4/4)
Peyer's patch 4 No
Pituitary gland 4 No
Prostate gland 4 No (12/584)
Skeletal muscle 4 No
Skin 4 No
Small intestine 4 No (9/584)
Spinal cord 4 No (4/4)
Spleen 4 No (2/584)
Stomach 4 No (12/584)
Striatum 4 No (4/4)
Testis 4 No (2/584) (2/4)
Thymus 4 No
Thyroid gland 4 No (15/584)
Trachea 4 No (4/4)
Uterus 4 No
Vascular system 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    nervous system
    set of connective tissues
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (1/2)
Ear 2 (1/485)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485) (1/2)
Foot 2 (1/485) (1/2)
Forebrain 2 (1/485) (1/2)
Forelimb 2 (1/485)
Hand 2 (1/485)
Head 2 (5/485) (1/2)
Heart 2 (1/485) (1/2)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485) (1/2)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485) (1/2)
Oral cavity 2 (1/485)
Skin 2 (1/485) (1/2)
Tail 2 (1/485) (1/2)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    60 Images
  • Adult LacZ: LacZ Images Wholemount
    9 Images
  • Echo: M-Mode Images
    68 Images
  • X-ray: XRay Images Lateral Orientation
    44 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    29 Images
  • X-ray: XRay Images Skull Lateral Orientation
    15 Images
  • X-ray: XRay Images Forepaw
    15 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images
  • X-ray: XRay Images Hind Leg and Hip
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Kdm8tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Kdm8tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene