Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
embryonic lethality prior to organogenesis | Tubgcp2em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
abnormal sternum morphology | Tubgcp2em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Tubgcp2em1(IMPC)Bay | HOM | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Tubgcp2em1(IMPC)Tcp | HOM | Early adult | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Tubgcp2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cortical Dysplasia, Complex, With Other Brain Malformations 15 | OMIM:618737 |
The table below shows human diseases predicted to be associated to Tubgcp2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cervical Rib | Cervical ribs | OMIM:117900 | |
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe | Bifid sternum | OMIM:140850 | |
Craniorachischisis | Bifid sternum | ORPHA:63260 | |
Coffin-Lowry Syndrome | Hyperextensibility of the finger joints, Short metacarpal, Bifid sternum, Tapered finger, Coxa va... | OMIM:303600 | |
Cortical Dysplasia, Complex, With Other Brain Malformations 15 | OMIM:618737 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Tubgcp2tm119211(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Tubgcp2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Tubgcp2em1(IMPC)Bay | Exon Deletion | Mice |
Tubgcp2em1(IMPC)Tcp | Exon Deletion | Mice |
Tubgcp2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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