Gene: Bloc1s2

Order

Name biogenesis of lysosomal organelles complex-1, subunit 2

Synonyms
  • Bloc1s2a
  • Bloc1s2
  • BLOS2
  • 2410089B13Rik

Status ES CellsMice
tm1.1
Mice
tm1
phenotype data available

Links MGI:1920939    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Bloc1s2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Bloc1s2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Bloc1s2tm1.1(KOMP)Mbp HOM Male embryonic day 12.5 0.0
abnormal limb bud morphology Bloc1s2tm1.1(KOMP)Mbp HOM Male embryonic day 12.5 0.0
abnormal pericardium morphology Bloc1s2tm1.1(KOMP)Mbp HOM Male embryonic day 12.5 0.0
abnormal placenta size Bloc1s2tm1.1(KOMP)Mbp HOM Female Male embryonic day 15.5 0.0
edema Bloc1s2tm1.1(KOMP)Mbp HOM Female Male embryonic day 15.5 0.0
hemorrhage Bloc1s2tm1.1(KOMP)Mbp HOM Female Male embryonic day 15.5 0.0
pale liver Bloc1s2tm1.1(KOMP)Mbp HOM Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Bloc1s2tm1.1(KOMP)Mbp HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Brain 2 No
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134)
Esophagus 2 No (7/415)
Eye 2 No (2/2)
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Submandibular gland 2 No (2/132)
Testis 2 No (2/584)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse digestive system nervous system set of connective tissues sensory organ reproductive system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485)
Dorsal root ganglion 1 (1/47)
Ear 2 (1/485)
Embryo 2 (1/485)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Fronto-nasal process 1 (1/48)
Hand 2 (1/485)
Head 2 (5/485)
Heart 2 (1/485)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485)
Nose 1 (1/51)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Spinal cord 1 (1/50)
Tail 2 (1/485)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Combined SHIRPA and Dysmorphology
    6 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Gross Morphology Embryo E12.5
    4 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Bloc1s2tm1.1(KOMP)Mbp Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Bloc1s2tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Bloc1s2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene