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Gene: Cul4b MGI:1919834

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cullin 4B
Synonyms:
2700050M05Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cul4b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cul4b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Abdominal obesity, Short stature, Striae distensae, Delayed puberty OMIM:300354
X-Linked Intellectual Disability, Cabezas Type
Short stature, Obesity, Cachexia ORPHA:85293

The table below shows human diseases predicted to be associated to Cul4b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Placental Insufficiency
Abnormal umbilical cord blood vessel morphology, Small for gestational age, Proportionate short s... ORPHA:439167
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Short stature, Small for gestational age, Postnatal growth retardation, Severe postnatal growth r... ORPHA:73272
Silver-Russell Syndrome Due To A Point Mutation
Small for gestational age, Postnatal growth retardation, Small placenta, Intrauterine growth reta... ORPHA:397590
Silver-Russell Syndrome Due To 11P15 Microduplication
Decreased fetal movement, Short stature, Small for gestational age, Postnatal growth retardation,... ORPHA:231144
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Small for gestational age, Polyhydramnios, Large for gestational age, Postnatal growth retardatio... ORPHA:254534
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Failure to thrive, Pallor ORPHA:79283
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Short stature, Pallor ORPHA:2786
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Growth delay, Failure to thrive, Pallor OMIM:613561
Fetal Akinesia Deformation Sequence 1
Decreased fetal movement, Small for gestational age, Premature birth, Polyhydramnios, Fetal akine... OMIM:208150
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Peripheral Cone Dystrophy
Pallor OMIM:609021
Congenital Heart Block
Premature birth, Hydrops fetalis, Vaginal birth after Caesarian, Pallor, Intrauterine growth reta... ORPHA:60041
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Redundant neck skin, Polyhydramnios, Postnatal growth retardation, Large placenta, Umbilical hern... ORPHA:254528
Optic Atrophy 1
Pallor OMIM:165500
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Acute Myelomonocytic Leukemia
Pallor, Weight loss ORPHA:517
Dermatitis, Atopic
Dry skin, Pallor, Facial erythema OMIM:603165
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Restrictive Dermopathy
Decreased fetal movement, Premature birth, Premature delivery because of cervical insufficiency o... ORPHA:1662
Cyclic Vomiting Syndrome
Growth delay, Pallor OMIM:500007
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Thiamine-Responsive Megaloblastic Anemia Syndrome
Short stature, Pallor ORPHA:49827
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight, Pallor ORPHA:276608
Anemia, Congenital Dyserythropoietic, Type Ib
Growth delay, Short stature, Pallor OMIM:615631
Neu-Laxova Syndrome 1
Decreased fetal movement, Spina bifida, Polyhydramnios, Fetal akinesia sequence, Stillbirth, Shor... OMIM:256520
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Failure to thrive, Short stature, Pallor OMIM:611590
Fanconi Anemia, Complementation Group I
Intrauterine growth retardation, Short stature, Pallor, Decreased body weight OMIM:609053
Hemoglobin D Disease
Pallor ORPHA:90039
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Hyperinsulinism Due To Hnf1A Deficiency
Small for gestational age, Pallor, Large for gestational age ORPHA:324575
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Breath-Holding Spells
Pallor OMIM:607578
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Nonimmune hydrops fetalis, Pallor OMIM:266200
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Growth delay, Failure to thrive, Pallor, Delayed puberty OMIM:600462
Mosaic Trisomy 16
Small for gestational age, Premature birth, Large placenta, Single umbilical artery, Intrauterine... ORPHA:1708
Hyperinsulinism Due To Ucp2 Deficiency
Pallor, Large for gestational age ORPHA:276556
Retinitis Pigmentosa 51
Pallor, Obesity OMIM:613464
Kagami-Ogata Syndrome
Premature birth, Polyhydramnios, Large for gestational age, Postnatal growth retardation, Large p... ORPHA:254519
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Pallor, Large for gestational age ORPHA:276575
Trichohepatoenteric Syndrome 1
Small for gestational age, Short stature, Polyhydramnios, Large placenta, Abnormalities of placen... OMIM:222470
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Pallor, Large for gestational age ORPHA:276580
Myopathic Ehlers-Danlos Syndrome
Failure to thrive, Pallor ORPHA:536516
Leishmaniasis
Pallor, Skin ulcer, Weight loss ORPHA:507
Hb Bart'S Hydrops Fetalis
Hydrops fetalis, Pallor, Polyhydramnios, Oligohydramnios ORPHA:163596
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Non-Functioning Paraganglioma
Pallor, Weight loss ORPHA:94080
Primary Myelofibrosis
Cachexia, Pallor, Ecchymosis, Petechiae, Purpura ORPHA:824
Greenberg Dysplasia
Rhizomelia, Nonimmune hydrops fetalis, Polyhydramnios, Echogenic fetal bowel, Large placenta, Inc... OMIM:215140
Anemia, Hypochromic Microcytic, With Iron Overload 2
Growth delay, Pallor OMIM:615234
Restrictive Dermopathy 1
Spontaneous chorioamniotic separation, Decreased fetal movement, Premature birth, Polyhydramnios,... OMIM:275210
Deafness-Lymphedema-Leukemia Syndrome
Pallor, Weight loss ORPHA:3226
Dravet Syndrome
Pallor ORPHA:33069
Evans Syndrome
Pallor, Petechiae ORPHA:1959
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Increased body weight, Pallor, Large for gestational age ORPHA:263455
Sepsis In Premature Infants
Small for gestational age, Premature birth, Pallor, Decreased body weight, Caesarian section, Pet... ORPHA:90051
Idiopathic Pulmonary Hemosiderosis
Failure to thrive, Pallor ORPHA:99931
Myopathy, Mitochondrial, And Ataxia
Growth delay, Short stature, Pallor OMIM:617675
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Dominant Beta-Thalassemia
Failure to thrive in infancy, Skin ulcer, Growth delay, Pallor, Delayed puberty ORPHA:231226
Congenital Dyserythropoietic Anemia Type Iii
Short stature, Pallor ORPHA:98870
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Redundant neck skin, Short stature, Premature birth, Polyhydramnios, Large for gestational age, P... ORPHA:96334
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Meckel Syndrome, Type 1
Occipital encephalocele, Large placenta, Breech presentation, Anencephaly, Single umbilical arter... OMIM:249000
Irida Syndrome
Pallor ORPHA:209981
Beta-Thalassemia Major
Failure to thrive in infancy, Skin ulcer, Growth delay, Pallor, Delayed puberty ORPHA:231214
Diamond-Blackfan Anemia 1
Short stature, Premature birth, Spina bifida occulta, Pallor, Intrauterine growth retardation, Fa... OMIM:105650
Hereditary Folate Malabsorption
Failure to thrive, Pallor ORPHA:90045
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Hereditary Spherocytosis
Growth delay, Pallor, Skin ulcer ORPHA:822
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Rheumatic Fever
Erythema, Pallor ORPHA:3099
Cold Agglutinin Disease
Pallor ORPHA:56425
Imerslund-Gräsbeck Syndrome
Failure to thrive, Pallor, Weight loss ORPHA:35858
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Growth delay, Pallor ORPHA:300298
Fanconi Anemia, Complementation Group C
Small for gestational age, Intrauterine growth retardation, Short stature, Anemic pallor OMIM:227645
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Myelofibrosis
Pallor, Purpura OMIM:254450
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor, Weight loss ORPHA:276621
American Trypanosomiasis
Pallor ORPHA:3386
Beta-Ketothiolase Deficiency
Pallor, Weight loss ORPHA:134
Esophageal Atresia
Small for gestational age, Failure to thrive in infancy, Polyhydramnios, Growth delay, Pallor, Ab... ORPHA:1199
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Failure to thrive, Pallor ORPHA:331206
Fumarase Deficiency
Bilateral fetal pyelectasis, Failure to thrive, Pallor, Polyhydramnios OMIM:606812
Retinitis Pigmentosa 75
Pallor OMIM:617023
Beckwith-Wiedemann Syndrome
Premature birth, Redundant skin, Polyhydramnios, Large for gestational age, Large placenta, Obesi... ORPHA:116
Tay-Sachs Disease
Pallor OMIM:272800
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
3-Hydroxy-3-Methylglutaric Aciduria
Pallor, Weight loss ORPHA:20
Pearson Marrow-Pancreas Syndrome
Small for gestational age, Erythema, Hydrops fetalis, Pallor, Failure to thrive OMIM:557000
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Prolactinoma
Pallor, Delayed puberty ORPHA:2965
Hereditary Pheochromocytoma-Paraganglioma
Pallor, Weight loss ORPHA:29072
Senior-Loken Syndrome 8
Pallor OMIM:616307
Fanconi Anemia, Complementation Group E
Small for gestational age, Short stature, Anemic pallor OMIM:600901
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor, Weight loss ORPHA:98849
Degcags Syndrome
Small for gestational age, Premature birth, Polyhydramnios, Echogenic fetal bowel, Breech present... OMIM:619488
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Incontinentia Pigmenti
Erythema, Short stature, Pallor OMIM:308300
Sheehan Syndrome
Dry skin, Pallor, Obesity ORPHA:91355
Fanconi Anemia, Complementation Group A
Small for gestational age, Short stature, Anemic pallor OMIM:227650
Waldenström Macroglobulinemia
Pallor, Purpura ORPHA:33226
Letterer-Siwe Disease
Pallor OMIM:246400
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Alternating Hemiplegia Of Childhood
Failure to thrive, Pallor ORPHA:2131
Diamond-Blackfan Anemia
Short stature, Nonimmune hydrops fetalis, Small for gestational age, Growth delay, Pallor ORPHA:124
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Growth delay, Anemic pallor ORPHA:329971
Elliptocytosis 1
Pallor OMIM:611804
Adenohypophysitis
Pallor ORPHA:95512
Panhypophysitis
Pallor ORPHA:95513
Pituitary Apoplexy
Pallor ORPHA:95613
Aregenerative Anemia
Pallor ORPHA:101096
Tsh-Secreting Pituitary Adenoma
Weight loss, Pallor, Delayed puberty ORPHA:91347
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Fanconi Anemia, Complementation Group D2
Small for gestational age, Short stature, Anemic pallor OMIM:227646
Histiocytoid Cardiomyopathy
Failure to thrive, Pallor ORPHA:137675
Refractory Anemia With Excess Blasts
Anemic pallor ORPHA:86839
Retinitis Pigmentosa And Erythrocytic Microcytosis
Pallor OMIM:616959
Idiopathic Hypereosinophilic Syndrome
Failure to thrive, Pallor ORPHA:3260
Autosomal Recessive Malignant Osteopetrosis
Growth delay, Pallor ORPHA:667
Infection-Related Hemolytic Uremic Syndrome
Pallor ORPHA:544482
Multiple Endocrine Neoplasia Type 2
Pallor ORPHA:653
Von Hippel-Lindau Disease
Pallor ORPHA:892
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor, Weight loss OMIM:233450
Congenital Total Pulmonary Venous Return Anomaly
Low 1-minute APGAR score, Low 5-minute APGAR score, Pallor ORPHA:99125
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Abdominal obesity, Short stature, Striae distensae, Delayed puberty OMIM:300354
X-Linked Intellectual Disability, Cabezas Type
Short stature, Obesity, Cachexia ORPHA:85293

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cul4b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cul4b.

No publications found that use IMPC mice or data for Cul4b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cul4btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cul4btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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