Gene: Hdac8

Phenotype associations for Hdac8

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Hdac8 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased monocyte cell number Hdac8tm1a(EUCOMM)Wtsi HEM Male postnatal 2.44E-10
decreased bone mineral density Hdac8tm1a(EUCOMM)Wtsi HOM Female postnatal 1.14E-7
decreased bone mineral content Hdac8tm1a(EUCOMM)Wtsi HOM Female postnatal 3.08E-7
decreased body length Hdac8tm1a(EUCOMM)Wtsi HEM Male postnatal 1.97E-5
decreased bone mineral density Hdac8tm1a(EUCOMM)Wtsi HEM Male postnatal 5.4E-5
increased monocyte cell number Hdac8tm1a(EUCOMM)Wtsi HOM Female postnatal 9.08E-5
increased circulating magnesium level Hdac8tm1a(EUCOMM)Wtsi HEM Male postnatal 9.55E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (1/2)
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/562) (1/2)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No (1/2)
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562) (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system endocrine system nervous system set of connective tissues reproductive system musculoskeletal system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (8)
  • Hdac8tm1a(EUCOMM)Wtsi
    OVARY, OVIDUCT, UTERUS, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    TRACHEA, THYROID GLAND, PARATHYROID GLAND, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI

show all 8 images

nervous system (5)
  • Hdac8tm1a(EUCOMM)Wtsi
    PERIPHERAL NERVOUS SYSTEM, PITUITARY GLAND, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    PITUITARY GLAND, HET, Male, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    SPINAL CORD, HET, Male, WTSI
endocrine system (2)
  • Hdac8tm1a(EUCOMM)Wtsi
    TRACHEA, THYROID GLAND, PARATHYROID GLAND, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
reproductive system (2)
  • Hdac8tm1a(EUCOMM)Wtsi
    OVARY, OVIDUCT, UTERUS, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
urinary system (2)
  • Hdac8tm1a(EUCOMM)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
cardiovascular system (1)
  • Hdac8tm1a(EUCOMM)Wtsi
    HEART, HET, Male, WTSI
musculoskeletal system (1)
  • Hdac8tm1a(EUCOMM)Wtsi
    SKELETAL MUSCLE TISSUE, CARTILAGE TISSUE, HET, Female, WTSI
respiratory system (1)
  • Hdac8tm1a(EUCOMM)Wtsi
    TRACHEA, THYROID GLAND, PARATHYROID GLAND, HET, Female, WTSI
set of connective tissues (1)
  • Hdac8tm1a(EUCOMM)Wtsi
    SKELETAL MUSCLE TISSUE, CARTILAGE TISSUE, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (118)
  • Hdac8tm1a(EUCOMM)Wtsi
    HEAD, HOM, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    HEAD, HOM, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    LOWER ARM, HOM, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    TRUNK, HEMI, Male, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    HEAD, HEMI, Male, WTSI

show all 118 images

Embryo Dysmorphology (3)
  • Hdac8tm1a(EUCOMM)Wtsi
    HEMI, Male, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
Eye Morphology (2)
  • Hdac8tm1a(EUCOMM)Wtsi
    EYE, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Hdac8tm1a(EUCOMM)Wtsi
    EYE, abnormal retinal pigmentation, persistence of hyaloid vascular system, HOM, Female, WTSI
Dysmorphology (1)
  • Hdac8tm1a(EUCOMM)Wtsi
    abnormal vagina morphology, HOM, Female, WTSI
Skin Histopathology (1)
  • Hdac8tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Hdac8tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene