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Gene: Tmem273 MGI:1916319

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Gene Summary

Name:
transmembrane protein 273
Synonyms:
1810011H11Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
vertebral transformation Tmem273em1(IMPC)Ccpcz HOM Early adult 6.58×10-06
abnormal kidney morphology Tmem273em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal tooth morphology Tmem273em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal vertebrae morphology Tmem273em1(IMPC)Ccpcz HOM Early adult 6.67×10-05
abnormal bone structure Tmem273em1(IMPC)Ccpcz HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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X-ray

XRay Images Whole Body Dorso Ventral

30 Images

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X-ray

XRay Images Hind Leg and Hip

31 Images

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X-ray

XRay Images Forepaw

15 Images

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X-ray

XRay Images Skull Lateral Orientation

15 Images

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X-ray

XRay Images Whole Body Lateral Orientation

15 Images

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Human diseases caused by Tmem273 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tmem273 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Osteomesopyknosis
Sclerotic vertebral body, Abnormal cortical bone morphology, Abnormal form of the vertebral bodie... ORPHA:2777
Regional Odontodysplasia
Yellow-brown discoloration of the teeth, Eruption failure, Abnormality of primary teeth, Short de... ORPHA:83450
Amelogenesis Imperfecta
Fragile teeth, Widely spaced teeth, Abnormal permanent molar morphology, Yellow-brown discolorati... ORPHA:88661
Dentin Dysplasia, Type I
Oligodontia, Short dental root, Microdontia, Enamel hypoplasia, Periapical bone loss, Pulp oblite... OMIM:125400
Pyle Disease
Reduced bone mineral density, Delayed eruption of teeth, Scoliosis, Mandibular prognathia, Hypopl... OMIM:265900
Florid Cemento-Osseous Dysplasia
Supernumerary tooth, Atrophy of alveolar ridges, Oral ulcer, Abnormality of primary teeth, Abnorm... ORPHA:83451
Primary Basilar Invagination
Short neck, Abnormal vertebral morphology, Abnormality of the cervical spine ORPHA:2285
Endosteal Hyperostosis, Worth Type
Clavicular sclerosis, Sclerotic vertebral body, Abnormal cortical bone morphology, Craniofacial h... ORPHA:2790
Endosteal Hyperostosis, Autosomal Dominant
Clavicular sclerosis, Sclerotic vertebral body, Metacarpal diaphyseal endosteal sclerosis, Hypero... OMIM:144750
Cleft Palate-Short Stature-Vertebral Anomalies Syndrome
Abnormal vertebral morphology, Micrognathia, Cleft palate, Short neck, Thin upper lip vermilion ORPHA:2015
Amelogenesis Imperfecta, Hypomaturation Type, Iia3
Amelogenesis imperfecta, Hypomature dental enamel, Enamel hypomineralization OMIM:613211
Spondylocostal Dysostosis 6, Autosomal Recessive
Butterfly vertebrae, Scoliosis, Hemivertebrae, Spinal canal stenosis, Cervical kyphosis OMIM:616566
Dentin Dysplasia
Abnormal dental morphology, Abnormal dental enamel morphology, Increased bone mineral density ORPHA:1653
Dental Anomalies And Short Stature
Amelogenesis imperfecta, Widely spaced teeth, Intervertebral space narrowing, Scoliosis, Mandibul... OMIM:601216
Amelogenesis Imperfecta, Type Ij
Amelogenesis imperfecta, Widely spaced teeth, Increased overbite, Abnormal dentin morphology, Car... OMIM:617297
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:204700
Oligodontia
Short dental root, Microdontia, Eclabion, Agenesis of maxillary lateral incisor, Taurodontia, Age... ORPHA:99798
Amelogenesis Imperfecta, Type Ia
Amelogenesis imperfecta, Enamel hypoplasia, Generalized microdontia, Dental enamel pits, Taurodontia OMIM:104530
Dentinogenesis Imperfecta-Short Stature-Hearing Loss-Intellectual Disability Syndrome
Short philtrum, Delayed eruption of teeth, Osteoporosis, Dentinogenesis imperfecta, Platyspondyly ORPHA:71267
Maxillonasal Dysplasia, Binder Type
Dental malocclusion, Patchy distortion of vertebrae, Vertebral clefting OMIM:155050
Metaphyseal Chondrodysplasia, Spahr Type
Reduced bone mineral density, Scoliosis, Hyperlordosis, Abnormality of the dentition, Carious teeth ORPHA:2501
Amelogenesis Imperfecta, Hypomaturation Type, Iia6
Amelogenesis imperfecta, Anterior open-bite malocclusion, Enamel hypomineralization OMIM:617217
Dentinogenesis Imperfecta, Shields Type Iii
Anterior open-bite malocclusion, Periapical bone loss, Dentinogenesis imperfecta, Dental enamel p... OMIM:125500
Dentin Dysplasia, Type Ii
Dentinogenesis imperfecta limited to primary teeth, Pulp calcification, Thistle tube shaped pulp OMIM:125420
Metaphyseal Dysplasia With Maxillary Hypoplasia With Or Without Brachydactyly
Thin vermilion border, Short philtrum, Premature loss of teeth, Multiple small vertebral fracture... OMIM:156510
Amelogenesis Imperfecta, Type Ic
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:204650
Amelogenesis Imperfecta, Type Iiia
Amelogenesis imperfecta, Dental malocclusion, Anterior open-bite malocclusion OMIM:130900
Greenberg Dysplasia
Abnormal bone ossification, Abnormal form of the vertebral bodies, Abnormal pelvis bone ossificat... ORPHA:1426
Amelogenesis Imperfecta, Type Ih
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:616221
Dentinogenesis Imperfecta
Fragile teeth, Grayish enamel, Yellow-brown discoloration of the teeth, Selective tooth agenesis,... ORPHA:49042
Dentin Dysplasia With Sclerotic Bones
Dentinogenesis imperfecta limited to primary teeth, Cortical sclerosis, Abnormality of the dentition OMIM:125440
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis
Kyphoscoliosis, Amelogenesis imperfecta, Scoliosis, Hyperlordosis, High palate, Mandibular progna... OMIM:618363
Hall-Riggs Syndrome
Microdontia of primary teeth, Hypoplasia of the primary teeth, Thick lower lip vermilion, Scolios... OMIM:234250
Otodental Dysplasia
Agenesis of premolar, Delayed eruption of teeth, Enamel hypoplasia, Long philtrum, Tooth ankylosi... OMIM:166750
Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:612529
Amelogenesis Imperfecta, Type Iiic
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:618386
Spondylocostal Dysostosis 3, Autosomal Recessive
Supernumerary vertebral ossification centers, Scoliosis, Vertebral segmentation defect, Kyphosis,... OMIM:609813
Amelogenesis Imperfecta, Hypomaturation Type, Iia4
Amelogenesis imperfecta, Enamel hypoplasia, Enamel hypomineralization OMIM:614832
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Carious teeth OMIM:615887
Amelogenesis Imperfecta, Type If
Amelogenesis imperfecta, Enamel hypoplasia, Dental enamel pits, Abnormality of dental color OMIM:616270
Flynn-Aird Syndrome
Kyphoscoliosis, Increased bone mineral density, Osteoporosis, Carious teeth, Increased bone densi... OMIM:136300
Weismann-Netter Syndrome
Scoliosis, Calvarial hyperostosis, Horizontal sacrum, Kyphosis, Delayed eruption of permanent teeth OMIM:112350
Amelogenesis Imperfecta, Type Ie
Amelogenesis imperfecta, Enamel hypoplasia, Anterior open-bite malocclusion, Abnormal dentin morp... OMIM:301200
Spondylocostal Dysostosis 2, Autosomal Recessive
Short neck, Hemivertebrae, Vertebral clefting, Vertebral segmentation defect OMIM:608681
Amelogenesis Imperfecta, Type Iv
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Enamel hypoplasia, Taurodontia OMIM:104510
Calvarial Doughnut Lesions With Bone Fragility
Osteopenia, Scoliosis, Osteoporosis, Carious teeth, Platyspondyly OMIM:126550
Intermediate Osteopetrosis
Sandwich appearance of vertebral bodies, Abnormality of bone mineral density, Cortical sclerosis,... ORPHA:210110
Acrodysplasia Scoliosis
Scoliosis, Vertebral segmentation defect, Spina bifida occulta ORPHA:2956
Pycnodysostosis
Narrow palate, Spondylolysis, Spondylolisthesis, Absent frontal sinuses, Increased bone mineral d... OMIM:265800
Microcephalic Primordial Dwarfism, Montreal Type
Abnormal palate morphology, Reduced bone mineral density, Scoliosis, Vertebral segmentation defec... ORPHA:2617
Spondyloepimetaphyseal Dysplasia Congenita, Strudwick Type
Abnormal vertebral morphology, Cervical instability, Delayed ossification of carpal bones, Glosso... ORPHA:93346
Otodental Syndrome
Agenesis of premolar, Abnormality of canine, Delayed eruption of teeth, Periodontitis, Abnormal d... ORPHA:2791
Tricho-Dento-Osseous Syndrome
Agenesis of incisor, Periapical tooth abscess, Widely spaced teeth, Increased bone mineral densit... ORPHA:3352
Mucopolysaccharidosis, Type Iva
Grayish enamel, Anterior beaking of lumbar vertebrae, Lumbar kyphosis, Widely spaced teeth, Kerat... OMIM:253000
Dysosteosclerosis
Craniofacial hyperostosis, Delayed eruption of teeth, Increased bone mineral density, Abnormal de... ORPHA:1782
Hypogonadotropic Hypogonadism 26 With Or Without Anosmia
Osteopenia, Supernumerary tooth, Agenesis of molar, Hypospadias, Bicoronal synostosis, Scoliosis,... OMIM:619718
Amelo-Onycho-Hypohidrotic Syndrome
Advanced eruption of teeth, Delayed eruption of teeth, Yellow-brown discoloration of the teeth, A... ORPHA:1028
Mucopolysaccharidosis Type 4
Grayish enamel, Reduced bone mineral density, Abnormal dental enamel morphology, Scoliosis, Hyper... ORPHA:582
Cleft Lip/Palate
Orofacial cleft, Abnormal number of permanent teeth, Palate fistula, Bilateral cleft palate, Peg-... ORPHA:199306
Steroid Dehydrogenase Deficiency-Dental Anomalies Syndrome
Abnormal dental enamel morphology, Enamel hypoplasia, Supernumerary tooth ORPHA:3196
Dysostosis, Stanescu Type
Abnormal palate morphology, Increased bone mineral density, Abnormal dental enamel morphology, Sc... ORPHA:1798
Shaheen Syndrome
Enamel hypoplasia, Carious teeth OMIM:615328
Craniolenticulosutural Dysplasia
Thin vermilion border, Delayed eruption of teeth, Premature loss of teeth, Scoliosis, High palate... ORPHA:50814
Craniometadiaphyseal Dysplasia
Osteopenia, Dental crowding, Scoliosis, Mandibular prognathia, High palate, Microdontia, Carious ... OMIM:269300
Dentinogenesis Imperfecta 1
Yellow-brown discoloration of the teeth, Dentinogenesis imperfecta OMIM:125490
Van Der Woude Syndrome 2
Cleft upper lip, Cleft palate, Anodontia, Hypodontia, Dental malocclusion, Lip pit OMIM:606713
Orofaciodigital Syndrome Type 5
Supernumerary tooth, High, narrow palate, Absent cupid's bow, Agenesis of canine, Cleft soft pala... ORPHA:2919
Hypophosphatasia, Adult
Rickets, Carious teeth, Premature loss of primary teeth, Osteomalacia, Premature loss of permanen... OMIM:146300
Pycnodysostosis
Spondylolysis, Spondylolisthesis, Hyperlordosis, Kyphosis, Delayed eruption of primary teeth, Inc... ORPHA:763
Sacral Agenesis With Vertebral Anomalies
Abnormal vertebral morphology, Unilateral renal agenesis, Persistent cloaca, Vertebral clefting, ... OMIM:615709
Mucopolysaccharidosis, Type Ivb
Grayish enamel, Widely spaced teeth, Keratan sulfate excretion in urine, Scoliosis, Hyperlordosis... OMIM:253010
Hypophosphatemic Rickets, Autosomal Recessive, 2
Hypophosphatemic rickets, Medullary nephrocalcinosis, Hypoplasia of teeth, Hyperphosphaturia, Car... OMIM:613312
Impacted Teeth, Multiple
Supernumerary tooth, Multiple impacted teeth OMIM:308280
Vacterl Association With Hydrocephalus
Renal hypoplasia, Abnormal vertebral morphology, Radial club hand, Abnormality of the vertebral c... OMIM:276950
Amelogenesis Imperfecta, Type Ig
Amelogenesis imperfecta, Polyuria, Gingival fibromatosis, Impaired renal concentrating ability, G... OMIM:204690
Enamel-Renal Syndrome
Amelogenesis imperfecta, Hypocalciuria, Renal insufficiency, Impaired renal concentrating ability... ORPHA:1031
Amelocerebrohypohidrotic Syndrome
Amelogenesis imperfecta, Abnormal dental enamel morphology, Yellow-brown discoloration of the tee... ORPHA:1946
Jalili Syndrome
Amelogenesis imperfecta, Abnormal dental enamel morphology, Abnormality of dental color ORPHA:1873
Odontomicronychial Dysplasia
Premature loss of primary teeth, Premature eruption of permanent teeth, Carious teeth, Abnormalit... ORPHA:1811
Familial Osteodysplasia, Anderson Type
Abnormal zygomatic bone morphology, Abnormal cortical bone morphology, Tooth malposition, Abnorma... ORPHA:2769
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1
Increased renal tubular phosphate reabsorption, Subperiosteal bone formation, Hyperostosis, Ename... OMIM:211900
Craniolenticulosutural Dysplasia
Osteopenia, Delayed eruption of teeth, Scoliosis, High palate, Carious teeth, Hypoplasia of teeth... OMIM:607812
Branchioskeletogenital Syndrome
Ureteral stenosis, Bifid uvula, Craniosynostosis, Abnormality of the vertebral spinous processes,... ORPHA:1299
Camurati-Engelmann Disease
Diaphyseal sclerosis, Increased bone mineral density, Scoliosis, Mandibular prognathia, Cortical ... OMIM:131300
Aspartylglucosaminuria
Beaking of vertebral bodies, Abnormal vertebral morphology, Anterior beaking of lumbar vertebrae,... ORPHA:93

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tmem273

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tmem273.

No publications found that use IMPC mice or data for Tmem273.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tmem273tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Tmem273tm379889(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Tmem273em1(IMPC)Ccpcz Indel Mice
Tmem273tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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