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Gene: Zfp414 MGI:1915641

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Gene Summary

Name:
zinc finger protein 414
Synonyms:
0610030H11Rik

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal head shape Zfp414em1(IMPC)Bay HOM E18.5 0.00
microcephaly Zfp414em1(IMPC)Bay HOM E18.5 0.00
anophthalmia Zfp414em1(IMPC)Bay HOM E18.5 0.00
abnormal head size Zfp414em1(IMPC)Bay HOM E18.5 0.00
abnormal facial morphology Zfp414em1(IMPC)Bay HOM E18.5 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

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MicroCT E18.5

Embryo reconstruction

6 Images

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Human diseases caused by Zfp414 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp414 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Miller-Dieker syndrome (MDS)
Frontal bossing, Lissencephaly, Midface retrusion, Microcephaly DECIPHER:21
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Microphthalmia, Anophthalmia ORPHA:85275
Microphthalmia, Isolated 1
Microphthalmia, Anophthalmia OMIM:251600
Microphthalmia, Isolated, With Coloboma 10
Microphthalmia, Anophthalmia OMIM:616428
Sporadic Fetal Brain Disruption Sequence
Prominent occiput, Plagiocephaly, Cerebral cortical atrophy, Microcephaly ORPHA:1665
Microphthalmia, Isolated, With Coloboma 5
Microphthalmia, Anophthalmia, Bilateral microphthalmos OMIM:611638
X-Linked Intellectual Disability-Plagiocephaly Syndrome
Diffuse cerebral atrophy, Flat occiput, Microcephaly, Brachycephaly, Plagiocephaly ORPHA:2898
Microphthalmia, Syndromic 16
Microphthalmia, Anophthalmia OMIM:611038
Oculocerebrocutaneous Syndrome
Anophthalmia, Hypoplasia of the corpus callosum, Microphthalmia, Agenesis of corpus callosum, Dan... OMIM:164180
Anencephaly 2
Anophthalmia, Anencephaly OMIM:619452
Microcephaly-Microcornea Syndrome, Seemanova Type
Microphthalmia, Brachycephaly, Microcephaly ORPHA:2528
Adenylosuccinate Lyase Deficiency
Flat occiput, Hypointensity of cerebral white matter on MRI, Brachycephaly, Microcephaly ORPHA:46
Fryns Microphthalmia Syndrome
Microphthalmia, Anophthalmia OMIM:600776
Microphthalmia, Isolated 8
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, True anophthalmia OMIM:615113
Meckel Syndrome, Type 8
Microphthalmia, Anophthalmia, Microcephaly OMIM:613885
Cleidocranial Dysplasia, Recessive Form
Brachycephaly OMIM:216330
Microphthalmia, Syndromic 12
Microphthalmia, Anophthalmia OMIM:615524
Intellectual Developmental Disorder, X-Linked 1
Secondary microcephaly, Brachycephaly OMIM:309530
Congenital Disorder Of Glycosylation, Type Iiy
Microcephaly, Brachycephaly, Cerebral cortical atrophy, Agenesis of corpus callosum, Thin corpus ... OMIM:620200
Osteosclerosis-Developmental Delay-Craniosynostosis Syndrome
Thickened calvaria, Brachycephaly, Craniosynostosis, Macrocephaly ORPHA:178377
Non-Distal Duplication 10Q
Frontal bossing, Aplasia/Hypoplasia affecting the eye, Brachycephaly, Microcephaly ORPHA:1695
Structural Brain Anomalies With Impaired Intellectual Development And Craniosynostosis
Flat occiput, Optic nerve hypoplasia, Microcephaly, Hypoplasia of the pons, Brachycephaly, Lambdo... OMIM:618736
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Hypoplasia of the pons, Occipital cortical atrophy, Anophthalmia, Hypoplasia of the corpus callosum ORPHA:411986
Corpus Callosum Agenesis-Macrocephaly-Hypertelorism Syndrome
Plagiocephaly, Agenesis of corpus callosum, Macrocephaly ORPHA:459074
Microphthalmia With Brain And Digit Anomalies
Anophthalmia, Microcephaly, Microphthalmia, Inferior cerebellar vermis hypoplasia, Agenesis of co... ORPHA:139471
Craniosynostosis 6
Turricephaly, Craniosynostosis, Microcephaly, Parietal foramina, Brachycephaly, Plagiocephaly, Ri... OMIM:616602
Walker-Warburg Syndrome
Anophthalmia, Absent septum pellucidum, Abnormal cortical gyration, Microcephaly, Macrogyria, Lis... ORPHA:899
Cortical Dysplasia, Complex, With Other Brain Malformations 13
Frontal polymicrogyria, Focal cortical dysplasia, Cerebellar vermis hypoplasia, Microcephaly, Pla... OMIM:614563
Kleefstra Syndrome 2
Plagiocephaly, Midface retrusion, Microcephaly OMIM:617768
Solitary Median Maxillary Central Incisor
Microphthalmia, Anophthalmia, Microcephaly OMIM:147250
Cerebrooculonasal Syndrome
Anophthalmia, Brachycephaly ORPHA:66625
Hydrolethalus
Anophthalmia, Absent septum pellucidum, Anencephaly, Microphthalmia, Agenesis of corpus callosum ORPHA:2189
Trisomy 13
Aplasia/Hypoplasia of the iris, Microphthalmia, Anophthalmia, Calvarial skull defect ORPHA:3378
Band Heterotopia
Subcortical band heterotopia, Plagiocephaly, Macrocephaly, Polymicrogyria, Agenesis of corpus cal... OMIM:600348
Trisomy 1Q
Frontal bossing, Anophthalmia, Cerebellar hypoplasia, Macrocephaly, Agenesis of corpus callosum ORPHA:261344
Cerebrooculonasal Syndrome
Frontal bossing, Anophthalmia, Cerebellar vermis hypoplasia, Optic nerve hypoplasia, Craniosynost... OMIM:605627
Developmental And Epileptic Encephalopathy 65
Plagiocephaly, Cerebral atrophy, Microcephaly OMIM:618008
Hemimegalencephaly
Pachygyria, Cranial asymmetry, Hemimegalencephaly, Macrocephaly, Hyperintensity of cerebral white... ORPHA:99802
Microphthalmia, Syndromic 3
Frontal bossing, Optic nerve aplasia, Anophthalmia, Optic nerve hypoplasia, Microcephaly, Hypopla... OMIM:206900
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Microphthalmia, Anophthalmia, Agenesis of corpus callosum ORPHA:77298
Anophthalmia Plus Syndrome
Anophthalmia ORPHA:1104
Microphthalmia With Limb Anomalies
Microphthalmia, Frontal bossing, Anophthalmia OMIM:206920
Microphthalmia, Syndromic 5
Microphthalmia, Anophthalmia, Optic nerve hypoplasia OMIM:610125
Crouzon Syndrome With Acanthosis Nigricans
Brachycephaly, Craniosynostosis, Midface retrusion OMIM:612247
Cockayne Syndrome Type 2
Anophthalmia, Subcortical white matter calcifications ORPHA:90322
Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia ORPHA:2717
Craniofacial Dyssynostosis With Short Stature
Frontal bossing, Brachycephaly, Hypoplasia of the corpus callosum, Abnormal shape of the occiput,... OMIM:218350
Overgrowth-Macrocephaly-Facial Dysmorphism Syndrome
Aplasia/Hypoplasia of the optic nerve, Cranial asymmetry, Optic nerve hypoplasia, Macrocephaly ORPHA:137634
Holoprosencephaly 9
Anophthalmia, Optic nerve hypoplasia, Abnormal cortical gyration, Microcephaly, Partial agenesis ... OMIM:610829
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Plagiocephaly, Anophthalmia, Aniridia, Dolichocephaly ORPHA:1101
Achard Syndrome
Broad skull, Brachycephaly OMIM:100700
Matthew-Wood Syndrome
Microphthalmia, Anophthalmia ORPHA:2470
Holoprosencephaly
Frontal bossing, Anophthalmia, Flat occiput, Microcephaly, Aplasia/Hypoplasia of the corpus callo... ORPHA:2162
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Microphthalmia, Anophthalmia, Macrocephaly OMIM:615877
Microgastria-Limb Reduction Defect Syndrome
Frontal bossing, Anophthalmia, Absent septum pellucidum, Abnormal cortical gyration, Plagiocephal... ORPHA:2538
Manitoba Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia OMIM:248450
Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies
Brachycephaly, Craniosynostosis OMIM:614416
Linear Nevus Sebaceus Syndrome
Frontal bossing, Cerebral calcification, Porencephalic cyst, Aplasia/Hypoplasia of the corpus cal... ORPHA:2612
Microphthalmia, Syndromic 6
Anophthalmia, Microcephaly, Brachycephaly, Aplasia/Hypoplasia of the corpus callosum, Plagiocepha... OMIM:607932
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia, Agenesis of corpus callosum, Brachycephaly ORPHA:264200
Craniosynostosis 2
Frontal bossing, Turricephaly, Craniosynostosis, Unicoronal synostosis, Brachycephaly, Trigonocep... OMIM:604757
Meckel Syndrome
Anophthalmia, Microcephaly, Anencephaly, Aplasia/Hypoplasia of the corpus callosum, Aplasia/Hypop... ORPHA:564
Cockayne Syndrome Type 1
Basal ganglia calcification, Anophthalmia ORPHA:90321
Fibular Hemimelia
Anophthalmia, Craniosynostosis ORPHA:93323
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Microphthalmia, Anophthalmia, Hypoplasia of the olfactory bulb ORPHA:2250
Microphthalmia With Linear Skin Defects Syndrome
Anophthalmia, Absent septum pellucidum, Microcephaly, Microphthalmia, Agenesis of corpus callosum... ORPHA:2556
Microphthalmia, Syndromic 9
Anophthalmia, Bilateral microphthalmos OMIM:601186
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Microphthalmia, Anophthalmia, Microcephaly ORPHA:2526
Vacterl With Hydrocephalus
Microphthalmia, Anophthalmia ORPHA:3412
Proboscis Lateralis
Anophthalmia, Optic nerve hypoplasia, Proboscis, Macrocephaly, Microphthalmia, Abnormal corpus ca... ORPHA:141099
Fraser Syndrome 1
Anophthalmia, Abnormal cortical gyration, Microcephaly, Bilateral microphthalmos, Calvarial skull... OMIM:219000
Joubert Syndrome 21
Hypoplasia of the brainstem, Anophthalmia, Hypoplasia of the corpus callosum OMIM:615636
Peroxisome Biogenesis Disorder 12A (Zellweger)
Scaphocephaly, Cranial asymmetry, Cerebral atrophy, Microcephaly OMIM:614886
Charge Syndrome
Anophthalmia, Microcephaly, Aplasia/Hypoplasia of the cerebellum, Microphthalmia, Dandy-Walker ma... ORPHA:138
Fraser Syndrome
Microphthalmia, Anophthalmia, Calvarial skull defect, Microcephaly ORPHA:2052
Microphthalmia, Syndromic 2
Anophthalmia, Microcephaly, Hypoplasia of the corpus callosum, Microphthalmia, Dandy-Walker malfo... OMIM:300166
Holoprosencephaly 7
Frontal bossing, Flat occiput, Microcephaly, Partial agenesis of the corpus callosum, Bilateral m... OMIM:610828
Focal Dermal Hypoplasia
Anophthalmia, Microcephaly, Aniridia, Microphthalmia, Agenesis of corpus callosum OMIM:305600
Microphthalmia With Limb Anomalies
Microphthalmia, Frontal bossing, True anophthalmia ORPHA:1106
Branchiooculofacial Syndrome
Agenesis of cerebellar vermis, Anophthalmia, Microcephaly, Dolichocephaly, Microphthalmia OMIM:113620
Charge Syndrome
Microphthalmia, Anophthalmia, Unilateral microphthalmos, Microcephaly OMIM:214800
Schimmelpenning-Feuerstein-Mims Syndrome
Cranial asymmetry, Hemimegalencephaly OMIM:163200
Arthrogryposis, Distal, Type 4
Cranial asymmetry OMIM:609128
Microphthalmia, Syndromic 1
Microphthalmia, Anophthalmia, Microcephaly OMIM:309800
Craniofacial Microsomia 1
Microphthalmia, Anophthalmia, Agenesis of corpus callosum OMIM:164210
Wiedemann-Rautenstrauch Syndrome
Thickened calvaria, Frontal bossing, Relative macrocephaly, Optic disc hypoplasia, Cranial asymme... ORPHA:3455

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp414

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp414.

No publications found that use IMPC mice or data for Zfp414.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Zfp414tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zfp414tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Zfp414tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zfp414tm463263(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Zfp414em1(IMPC)Bay Exon Deletion Mice
Zfp414tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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