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Gene: Apoo MGI:1915566

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Gene Summary

Name:
apolipoprotein O
Synonyms:
1110019O03Rik,  0610008C08Rik,  Micos26

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating iron level Apootm1b(KOMP)Wtsi HEM Early adult 6.56×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A hemizygote 100% (1 of 1)
Adrenal gland N/A heterozygote 100% (1 of 1)
Aorta N/A hemizygote 100% (1 of 1)
Aorta N/A heterozygote 0.0% (0 of 1)
Blood vessel N/A hemizygote 0.0% (0 of 1)
Blood vessel N/A heterozygote 0.0% (0 of 1)
Bone N/A hemizygote Ambiguous
Bone N/A heterozygote 0.0% (0 of 1)
Brain N/A hemizygote 100% (1 of 1)
Brain N/A heterozygote 100% (1 of 1)
Brainstem N/A hemizygote 100% (1 of 1)
Brainstem N/A heterozygote 100% (1 of 1)
Brown adipose tissue N/A hemizygote 100% (1 of 1)
Brown adipose tissue N/A heterozygote Ambiguous
Cartilage tissue N/A hemizygote Ambiguous
Cartilage tissue N/A heterozygote 0.0% (0 of 1)
Cerebellum N/A hemizygote 100% (1 of 1)
Cerebellum N/A heterozygote 100% (1 of 1)
Cerebral cortex N/A hemizygote 100% (1 of 1)
Cerebral cortex N/A heterozygote 100% (1 of 1)
Eye N/A hemizygote 0.0% (0 of 1)
Eye N/A heterozygote 0.0% (0 of 1)
Gall bladder N/A hemizygote 100% (1 of 1)
Gall bladder N/A heterozygote 0.0% (0 of 1)
Heart N/A hemizygote 100% (1 of 1)
Heart N/A heterozygote 100% (1 of 1)
Hippocampus N/A hemizygote 100% (1 of 1)
Hippocampus N/A heterozygote 100% (1 of 1)
Hypothalamus N/A hemizygote 100% (1 of 1)
Hypothalamus N/A heterozygote 100% (1 of 1)
Kidney N/A hemizygote 100% (1 of 1)
Kidney N/A heterozygote 100% (1 of 1)
Large intestine N/A hemizygote 100% (1 of 1)
Large intestine N/A heterozygote 100% (1 of 1)
Liver N/A hemizygote 0.0% (0 of 1)
Liver N/A heterozygote 0.0% (0 of 1)
Lower urinary tract N/A hemizygote 100% (1 of 1)
Lower urinary tract N/A heterozygote Ambiguous
Lung N/A hemizygote 100% (1 of 1)
Lung N/A heterozygote 100% (1 of 1)
Lymph node N/A hemizygote 0.0% (0 of 1)
Lymph node N/A heterozygote 0.0% (0 of 1)
Mammary gland N/A hemizygote 0.0% (0 of 1)
Mammary gland N/A heterozygote 0.0% (0 of 1)
Esophagus N/A hemizygote 100% (1 of 1)
Esophagus N/A heterozygote 0.0% (0 of 1)
Olfactory lobe N/A hemizygote 100% (1 of 1)
Olfactory lobe N/A heterozygote 100% (1 of 1)
Ovary N/A hemizygote Not available
Ovary N/A heterozygote 100% (1 of 1)
Oviduct N/A hemizygote Not available
Oviduct N/A heterozygote 100% (1 of 1)
Pancreas N/A hemizygote 100% (1 of 1)
Pancreas N/A heterozygote 100% (1 of 1)
Parathyroid gland N/A hemizygote 100% (1 of 1)
Parathyroid gland N/A heterozygote 100% (1 of 1)
Peripheral nervous system N/A hemizygote 100% (1 of 1)
Peripheral nervous system N/A heterozygote 100% (1 of 1)
Peyer's patch N/A hemizygote 0.0% (0 of 1)
Peyer's patch N/A heterozygote 0.0% (0 of 1)
Pituitary gland N/A hemizygote 100% (1 of 1)
Pituitary gland N/A heterozygote 100% (1 of 1)
Prostate gland N/A hemizygote 100% (1 of 1)
Prostate gland N/A heterozygote Not available
Skeletal muscle tissue N/A hemizygote 100% (1 of 1)
Skeletal muscle tissue N/A heterozygote 0.0% (0 of 1)
Skin N/A hemizygote 100% (1 of 1)
Skin N/A heterozygote 0.0% (0 of 1)
Small intestine N/A hemizygote 100% (1 of 1)
Small intestine N/A heterozygote 100% (1 of 1)
Spinal cord N/A hemizygote 100% (1 of 1)
Spinal cord N/A heterozygote 100% (1 of 1)
Spleen N/A hemizygote 0.0% (0 of 1)
Spleen N/A heterozygote 0.0% (0 of 1)
Stomach N/A hemizygote 100% (1 of 1)
Stomach N/A heterozygote 0.0% (0 of 1)
Striatum N/A hemizygote 100% (1 of 1)
Striatum N/A heterozygote 100% (1 of 1)
Testis N/A hemizygote 100% (1 of 1)
Testis N/A heterozygote Not available
Thymus N/A hemizygote 100% (1 of 1)
Thymus N/A heterozygote 0.0% (0 of 1)
Thyroid gland N/A hemizygote 100% (1 of 1)
Thyroid gland N/A heterozygote Ambiguous
Trachea N/A hemizygote 100% (1 of 1)
Trachea N/A heterozygote 0.0% (0 of 1)
Uterus N/A hemizygote Not available
Uterus N/A heterozygote 0.0% (0 of 1)
White adipose tissue N/A hemizygote 0.0% (0 of 1)
White adipose tissue N/A heterozygote 0.0% (0 of 1)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood vessel
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
oesophagus
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyer's patch
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle tissue
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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Anti-nuclear antibody assay

Images

6 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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DSS Histology

Images

8 Images

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X-ray

XRay Images Forepaw

14 Images

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Ear epidermis immunophenotyping

Images

12 Images

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Legacy Phenotype Associated Images
Apootm1b(KOMP)Wtsi
HEMI, Male, WTSI
Apootm1b(KOMP)Wtsi
HEMI, Male, WTSI
Apootm1b(KOMP)Wtsi
HEMI, Male, WTSI
Apootm1b(KOMP)Wtsi
HEMI, Male, WTSI
Apootm1b(KOMP)Wtsi
HEMI, Male, WTSI

View all 70 images

Apootm1b(KOMP)Wtsi
cleft lip, HOM, Female, WTSI
Apootm1b(KOMP)Wtsi
cleft lip, HOM, Female, WTSI
Apootm1b(KOMP)Wtsi
abnormal snout morphology, upturned snout, asymmetric snout, head, HOM, Female, WTSI
Apootm1b(KOMP)Wtsi
abnormal snout morphology, upturned snout, asymmetric snout, head, HOM, Female, WTSI
Apootm1b(KOMP)Wtsi
TS20 eye, HET, Female, WTSI
Apootm1b(KOMP)Wtsi
TS20 spinal cord, HET, Female, WTSI
Apootm1b(KOMP)Wtsi
TS20 oral cavity, HET, Female, WTSI
Apootm1b(KOMP)Wtsi
TS20 maxillary process, HET, Female, WTSI

Human diseases caused by Apoo mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Apoo by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hemochromatosis, Type 5
Increased circulating ferritin concentration, Elevated transferrin saturation, Abnormal circulati... OMIM:615517
Iron Overload, Susceptibility To
Elevated circulating hepcidin concentration, Increased circulating ferritin concentration, Elevat... OMIM:620121
Genetic Hyperferritinemia Without Iron Overload
Increased circulating ferritin concentration, Abnormal serum iron concentration, Abnormal transfe... ORPHA:254704
Anemia, Sideroblastic, 2, Pyridoxine-Refractory
Increased circulating ferritin concentration, Elevated transferrin saturation OMIM:205950
Gracile Syndrome
Increased serum pyruvate, Increased circulating ferritin concentration, Increased serum iron OMIM:603358
Anemia, Hypochromic Microcytic, With Iron Overload 1
Increased serum iron, Elevated hepatic iron concentration OMIM:206100
Hjv Or Hamp-Related Hemochromatosis
Increased circulating ferritin concentration, Elevated transferrin saturation, Abnormality of iro... ORPHA:79230
Zinc Deficiency, Transient Neonatal
Decreased serum zinc OMIM:608118
Hemochromatosis, Neonatal
Increased circulating ferritin concentration, Increased serum iron, Abnormality of iron homeostasis OMIM:231100
Hemochromatosis, Type 2B
Increased circulating ferritin concentration, Elevated transferrin saturation, Increased serum iron OMIM:613313
X-Linked Sideroblastic Anemia
Abnormality of iron homeostasis ORPHA:75563
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Increased circulating ferritin concentration, Elevated transferrin saturation, Increased serum ir... ORPHA:766
Gracile Syndrome
Decreased transferrin saturation, Increased circulating ferritin concentration, Elevated hepatic ... ORPHA:53693
Anemia, Hypochromic Microcytic, With Iron Overload 2
Increased circulating ferritin concentration, Elevated transferrin saturation, Elevated hepatic i... OMIM:615234
Beta-Thalassemia
Abnormality of iron homeostasis ORPHA:848
Symptomatic Form Of Hfe-Related Hemochromatosis
Increased circulating ferritin concentration, Elevated transferrin saturation, Abnormality of iro... ORPHA:465508
Beta-Thalassemia Intermedia
Abnormality of iron homeostasis, Elevated hepatic iron concentration ORPHA:231222
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Abnormal blood inorganic cation concentration, Hyperglycinemia, Increased total iron binding capa... ORPHA:309854
Trichohepatoenteric Syndrome 1
Hypermethioninemia, Increased serum iron, Hypoalbuminemia, Abnormality of iron homeostasis OMIM:222470
Dominant Beta-Thalassemia
Abnormality of iron homeostasis ORPHA:231226
Beta-Thalassemia Major
Abnormality of iron homeostasis ORPHA:231214
Syndromic Diarrhea
Abnormality of iron homeostasis ORPHA:84064

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Apoo

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Apoo.

There are 8 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis. Atherosclerosis (November 2023) Apootm1c(KOMP)Wtsi Apootm1a(KOMP)Wtsi 37995600
Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes. Metabolism: clinical and experimental (April 2023) Apootm1c(KOMP)Wtsi Apootm1a(KOMP)Wtsi 37088120
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Apootm1b(KOMP)Wtsi Apooltm1a(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Apootm1b(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Apootm1b(KOMP)Wtsi Apooltm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Apootm1b(KOMP)Wtsi Apooltm1a(KOMP)Wtsi Apooltm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Apootm1b(KOMP)Wtsi Apooltm1a(KOMP)Wtsi PMC5827107
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Disease models & mechanisms (August 2015) Apootm1b(KOMP)Wtsi PMC4631787

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Apootm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Apootm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Apootm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

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