Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Tubb4b by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Leber Congenital Amaurosis With Early-Onset Deafness | OMIM:617879 | ||
Leber Congenital Amaurosis | ORPHA:65 |
The table below shows human diseases predicted to be associated to Tubb4b by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Leber Congenital Amaurosis With Early-Onset Deafness | OMIM:617879 | ||
Leber Congenital Amaurosis | ORPHA:65 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tubb4b.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Tubb4b is required for multi-ciliogenesis in the mouse. | Development (Cambridge, England) (January 2024) | Tubb4btm2a(EUCOMM)Wtsi Tubb4btm2b(EUCOMM)Wtsi | PMC10820790 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Tubb4btm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Tubb4btm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Tubb4bem1(IMPC)J | Exon Deletion | Mice |
Tubb4btm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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