Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Patl2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Female Infertility Due To Oocyte Meiotic Arrest | Female infertility, Polycystic ovaries, Abnormal spermatogenesis, Oocyte arrest at metaphase I, A... | ORPHA:488191 | |
Oocyte/Zygote/Embryo Maturation Arrest 4 | Oocyte arrest at metaphase I, Female infertility | OMIM:617743 |
The table below shows human diseases predicted to be associated to Patl2 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Patl2.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice. | EMBO molecular medicine (May 2018) | Patl2tm1a(EUCOMM)Hmgu | PMC5938616 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Patl2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Patl2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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