Gene: Sdha

Order

Name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Synonyms
  • SDHF
  • FP
  • SDH2
  • 2310034D06Rik

Status ES CellsMice
tm2a
Mice
tm2b
phenotype data available

Links MGI:1914195    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Sdha

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sdha data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Sdhatm2b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
preweaning lethality, complete penetrance Sdhatm2b(KOMP)Wtsi HOM Female Male n/a 0.0
increased circulating sodium level Sdhatm2b(KOMP)Wtsi HET Female Male postnatal 1.7E-5
decreased circulating glucose level Sdhatm2b(KOMP)Wtsi HET Female Male postnatal 7.59E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone marrow 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/485) (1/1)
Ear 1 (1/485)
Embryo 1 (1/485) (1/1)
Eye 1 (1/485) (1/1)
Foot 1 (1/485) (1/1)
Forebrain 1 (1/485) (1/1)
Forelimb 1 (1/485) (1/1)
Hand 1 (1/485) (1/1)
Head 1 (5/485) (1/1)
Heart 1 (1/485) (1/1)
Hindbrain 1 (6/485) (1/1)
Hindlimb 1 (1/485) (1/1)
Liver 1 (1/485)
Lung 1 (1/485)
Mandibular process 1 (1/485) (1/1)
Maxillary process 1 (1/485) (1/1)
Midbrain 1 (1/485) (1/1)
Oral cavity 1 (1/485) (1/1)
Skin 1 (1/485) (1/1)
Tail 1 (1/485) (1/1)
Tail somite 1 (1/485) (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • Combined SHIRPA and Dysmorphology
    6 Images
  • Sleep Wake: Wake state (bmp file)
    1 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Sdhatm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Sdhatm2b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Sdhatm50282(L1L2_Bact_P)
Vector
Gene