Gene: Eif4e3

Order

Name eukaryotic translation initiation factor 4E member 3

Synonyms
  • eIF4E-3
  • 1300018P11Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1914142    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Eif4e3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Eif4e3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased circulating alanine transaminase level Eif4e3tm1a(KOMP)Wtsi HOM Female Male postnatal 3.54E-8
decreased circulating HDL cholesterol level Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 8.9E-8
decreased circulating cholesterol level Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 1.44E-6
decreased lactate dehydrogenase level Eif4e3tm1a(KOMP)Wtsi HOM Female Male postnatal 8.71E-6
decreased total body fat amount Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 1.88E-5
decreased circulating calcium level Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 2.46E-5
decreased circulating aspartate transaminase level Eif4e3tm1a(KOMP)Wtsi HOM Female Male postnatal 2.59E-5
decreased circulating LDL cholesterol level Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 3.54E-5
decreased body weight Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 7.72E-5
decreased circulating serum albumin level Eif4e3tm1a(KOMP)Wtsi HOM Male postnatal 9.96E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No (1/2)
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584) (1/2)
Liver 2 No
Lower urinary tract 2 No (1/2)
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584) (1/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse digestive system cardiovascular system nervous system set of connective tissues reproductive system adipose tissue trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (12)
  • Eif4e3tm1a(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    small intestine, HET, Male, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI

show all 12 images

trunk (9)
  • Eif4e3tm1a(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    small intestine, HET, Male, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI

show all 9 images

nervous system (4)
  • Eif4e3tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    peripheral nervous system, HET, Male, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    spinal cord, HET, Male, WTSI
digestive system (3)
  • Eif4e3tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    small intestine, HET, Male, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    large intestine, HET, Male, WTSI
reproductive system (2)
  • Eif4e3tm1a(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
cardiovascular system (1)
  • Eif4e3tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
endocrine system (1)
  • Eif4e3tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
urinary system (1)
  • Eif4e3tm1a(KOMP)Wtsi
    lower urinary tract, urinary bladder, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (85)
  • Eif4e3tm1a(KOMP)Wtsi
    body, HOM, Male, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    forearm, HOM, Male, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    WT, Female, WTSI

show all 85 images

Skin Histopathology (3)
  • Eif4e3tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Eif4e3tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Eif4e3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Eif4e3tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Eif4e3tm41583(L1L2_gt2)
Vector
Gene