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Gene: Wdr45b MGI:1914090

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Gene Summary

Name:
WD repeat domain 45B
Synonyms:
Wdr45l,  0610008N23Rik,  D16Bwg0193e

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IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Wdr45bem1(IMPC)Bay HOM E18.5 0.00
preweaning lethality, incomplete penetrance Wdr45bem1(IMPC)Bay HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Eye Morphology

VIP of right eye

14 Images

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Eye Morphology

VIP of right fundus

14 Images

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Eye Morphology

VIP of left fundus

14 Images

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Eye Morphology

VIP of left eye

14 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Forepaw

10 Images

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MicroCT E18.5

Embryo reconstruction

8 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Human diseases caused by Wdr45b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Wdr45b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neurodevelopmental Disorder With Spastic Quadriplegia And Brain Abnormalities With Or Without Seizures
OMIM:617977

The table below shows human diseases predicted to be associated to Wdr45b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neurodevelopmental Disorder With Spastic Quadriplegia And Brain Abnormalities With Or Without Seizures
OMIM:617977

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Wdr45b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Wdr45b.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nature communications (October 2020) Wdr45btm1a(EUCOMM)Hmgu PMC7576787

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Wdr45btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Wdr45btm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Wdr45bem1(IMPC)Bay Exon Deletion Mice

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