Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Uqcrh by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mitochondrial Complex Iii Deficiency, Nuclear Type 11 | OMIM:620137 |
The table below shows human diseases predicted to be associated to Uqcrh by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mitochondrial Complex Iii Deficiency, Nuclear Type 11 | OMIM:620137 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Uqcrh.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease. | Biochimica et biophysica acta. Molecular basis of disease (May 2023) | Uqcrhtm1b(EUCOMM)Wtsi | 37230398 |
Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. | Mammalian genome : official journal of the International Mammalian Genome Society (December 2022) | Uqcrhtm1b(EUCOMM)Wtsi | 36565314 |
Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes. | EMBO molecular medicine (November 2021) | Uqcrhtm1a(EUCOMM)Wtsi Uqcrhtm1b(EUCOMM)Wtsi | PMC8649870 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Uqcrhtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Uqcrhtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Uqcrhtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Uqcrhtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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