Gene: Med11

Order

Name mediator complex subunit 11

Synonyms 1110030J09Rik

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1913422    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Med11

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Med11 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal tail bud morphology Med11tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Med11tm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Med11tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
increased fasted circulating glucose level Med11tm1.1(KOMP)Vlcg HET Female Male postnatal 3.74E-7
decreased circulating calcium level Med11tm1.1(KOMP)Vlcg HET Female Male postnatal 3.0E-5
decreased circulating glucose level Med11tm1.1(KOMP)Vlcg HET Male postnatal 8.26E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone marrow 1 No (1/1)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No (1/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (2/2)
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (1/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/2)
Dorsal root ganglion 1 (1/47) (1/1)
Ear 2 (1/485) (1/2)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485) (2/2)
Foot 2 (1/485) (2/2)
Forebrain 2 (1/485) (2/2)
Forelimb 2 (1/485) (2/2)
Fronto-nasal process 1 (1/48) Image Only
Hand 2 (1/485) (2/2)
Head 2 (5/485) (2/2)
Heart 2 (1/485) (2/2)
Hindbrain 2 (6/485) (2/2)
Hindlimb 2 (1/485) (2/2)
Liver 2 (1/485)
Lung 2 (1/485) Image Only
Mandibular process 2 (1/485) (2/2)
Maxillary process 2 (1/485) (2/2)
Midbrain 2 (1/485) (2/2)
Nose 1 (1/51) (1/1)
Oral cavity 2 (1/485) (1/2)
Skin 2 (1/485) (2/2)
Spinal cord 1 (1/50) (1/1)
Tail 2 (1/485) (2/2)
Tail somite 2 (1/485) (1/2)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Sleep Wake: Wake state (bmp file)
    16 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Combined SHIRPA and Dysmorphology
    2 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • Gross Morphology Embryo E9.5
    2 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Electroretinography: Cone waveform (pdf format)
    4 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Med11tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Med11tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Med11tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Med11tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Med11tm438123(L1L2_Bact_P)
Vector
Gene