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Gene: Bccip MGI:1913415

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Gene Summary

Name:
BRCA2 and CDKN1A interacting protein
Synonyms:
TOK-1,  1110013J05Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal retina blood vessel morphology Bcciptm1b(EUCOMM)Hmgu HET   Early adult 5.90×10-05
preweaning lethality, complete penetrance Bcciptm1b(EUCOMM)Hmgu HOM   Early adult 7.53×10-05
decreased exploration in new environment Bcciptm1b(EUCOMM)Hmgu HET Early adult 1.04×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Electrocardiogram (ECG)

Waveform Image

36 Images

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X-ray

XRay Images Whole Body Lateral Orientation

8 Images

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Immunophenotyping

Panel B FCS file(s)

6 Images

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Immunophenotyping

Panel A FCS file(s)

6 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Human diseases caused by Bccip mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bccip

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bccip.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Requirement of Bccip for the Regeneration of Intestinal Progenitors. The American journal of pathology (October 2020) Bcciptm1c(EUCOMM)Hmgu 33039352
Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice. The American journal of pathology (March 2020) Bcciptm1c(EUCOMM)Hmgu Bcciptm1a(EUCOMM)Hmgu Bcciptm1d(EUCOMM)Hmgu 32201259

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bcciptm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Bcciptm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Bcciptm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bcciptm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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