Gene: Laptm4b MGI:1890494
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal midbrain morphology | Laptm4btm1e.1(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
abnormal craniofacial morphology | Laptm4btm1e.1(KOMP)Wtsi | HOM | E15.5 | 0.00 | ||
decreased prepulse inhibition | Laptm4btm1e.1(KOMP)Wtsi | HET | Early adult | 1.62×10-09 | ||
abnormal eye morphology | Laptm4btm1e.1(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
abnormal neural tube closure | Laptm4btm1e.1(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
preweaning lethality, complete penetrance | Laptm4btm1e.1(KOMP)Wtsi | HOM | Early adult | 0.00 | ||
abnormal embryo size | Laptm4btm1e.1(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
preweaning lethality, incomplete penetrance | Laptm4btm1e.1(KOMP)Wtsi | HOM | Early adult | 0.00 | ||
abnormal hindbrain morphology | Laptm4btm1e.1(KOMP)Wtsi | HOM | E12.5 | 0.00 | ||
edema | Laptm4btm1e.1(KOMP)Wtsi | HOM | E15.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
N/A | Ambiguous | ||
Axial skeleton | N/A | homozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | Ambiguous |
Brain | N/A | homozygote | 0.0% (0 of 5) |
N/A | Ambiguous | ||
Central nervous system ganglion | N/A | homozygote | 0.0% (0 of 2) |
Ear | N/A | heterozygote | Ambiguous |
Ear | N/A | homozygote | 0.0% (0 of 5) |
Embryo | N/A | heterozygote | 0.0% (0 of 3) |
Embryo | N/A | homozygote | 0.0% (0 of 5) |
Eye | N/A | heterozygote | Ambiguous |
Eye | N/A | homozygote | 0.0% (0 of 5) |
Footplate | N/A | heterozygote | Ambiguous |
Footplate | N/A | homozygote | 0.0% (0 of 5) |
Forebrain | N/A | heterozygote | Ambiguous |
Forebrain | N/A | homozygote | 0.0% (0 of 5) |
Forelimb | N/A | heterozygote | Ambiguous |
Forelimb | N/A | homozygote | 0.0% (0 of 5) |
N/A | Ambiguous | ||
Gut | N/A | homozygote | 0.0% (0 of 2) |
Handplate | N/A | heterozygote | Ambiguous |
Handplate | N/A | homozygote | 0.0% (0 of 5) |
Head | N/A | heterozygote | Ambiguous |
Head | N/A | homozygote | 0.0% (0 of 5) |
Heart | N/A | heterozygote | Ambiguous |
Heart | N/A | homozygote | 0.0% (0 of 5) |
Hindbrain | N/A | heterozygote | Ambiguous |
Hindbrain | N/A | homozygote | 0.0% (0 of 5) |
Hindlimb | N/A | heterozygote | Ambiguous |
Hindlimb | N/A | homozygote | 0.0% (0 of 5) |
Liver | N/A | heterozygote | Ambiguous |
Liver | N/A | homozygote | 20% (1 of 5) |
Lung | N/A | heterozygote | Ambiguous |
Lung | N/A | homozygote | 0.0% (0 of 5) |
Mandibular process | N/A | heterozygote | Ambiguous |
Mandibular process | N/A | homozygote | 0.0% (0 of 5) |
Maxillary process | N/A | heterozygote | Ambiguous |
Maxillary process | N/A | homozygote | 0.0% (0 of 5) |
Midbrain | N/A | heterozygote | Ambiguous |
Midbrain | N/A | homozygote | 0.0% (0 of 5) |
N/A | Ambiguous | ||
Nose | N/A | homozygote | 0.0% (0 of 2) |
Oral cavity | N/A | heterozygote | Ambiguous |
Oral cavity | N/A | homozygote | 0.0% (0 of 5) |
N/A | Ambiguous | ||
Chorioallantoic placenta | N/A | homozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Skeleton | N/A | homozygote | 0.0% (0 of 2) |
Skin | N/A | heterozygote | Ambiguous |
Skin | N/A | homozygote | 0.0% (0 of 5) |
N/A | Ambiguous | ||
Spinal cord | N/A | homozygote | 0.0% (0 of 2) |
Tail somite | N/A | heterozygote | Ambiguous |
Tail somite | N/A | homozygote | 0.0% (0 of 5) |
Tail | N/A | heterozygote | Ambiguous |
Tail | N/A | homozygote | 0.0% (0 of 5) |
N/A | Ambiguous | ||
Trachea | N/A | homozygote | 0.0% (0 of 2) |
N/A | Ambiguous | ||
Urinary system | N/A | homozygote | 50% (1 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | Ambiguous |
brain | 0.0% |
central nervous system ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
gut | Ambiguous |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
oral cavity | 0.0% |
placenta | Ambiguous |
skeleton | Ambiguous |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
trachea | Ambiguous |
urinary system | Ambiguous |
Human diseases caused by Laptm4b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Laptm4b by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Laptm4b
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MGI Allele | Allele Type | Produced |
---|---|---|
Laptm4btm1e.1(KOMP)Wtsi | Promoter excision from Targeted, non-conditional allele | Mice, Tissue |
Laptm4btm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Laptm4btm1e(KOMP)Wtsi | Targeted, non-conditional allele | Mice, ES Cells |
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