Gene: Foxo1

Order

Name forkhead box O1

Synonyms
  • Foxo1a
  • Afxh
  • Fkhr1
  • FKHR

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:1890077    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Foxo1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Foxo1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Foxo1tm1b(EUCOMM)Wtsi HET Female embryonic day 9.5 0.0
abnormal hindbrain development Foxo1tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 9.5 0.0
abnormal midbrain development Foxo1tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 9.5 0.0
embryonic growth retardation Foxo1tm1b(EUCOMM)Wtsi HET Female Male embryonic day 9.5 0.0
embryonic growth retardation Foxo1tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 9.5 0.0
preweaning lethality, complete penetrance Foxo1tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Epididymis 2 No (4/106) (1/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (1/2)
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Submandibular gland 2 No (1/104) (2/2)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/482) (1/1)
Dorsal root ganglion 1 (1/45) (1/1)
Ear 1 (1/482) Image Only
Embryo 1 (1/482) (1/1)
Eye 1 (1/482) (1/1)
Foot 1 (1/482) (1/1)
Forebrain 1 (1/482) (1/1)
Forelimb 1 (1/482) (1/1)
Fronto-nasal process 1 (1/46) Image Only
Hand 1 (1/482) (1/1)
Head 1 (5/482) (1/1)
Heart 1 (1/482) (1/1)
Hindbrain 1 (6/482) (1/1)
Hindlimb 1 (1/482) (1/1)
Liver 1 (1/482)
Lung 1 (1/482) Image Only
Mandibular process 1 (1/482) (1/1)
Maxillary process 1 (1/482) (1/1)
Midbrain 1 (1/482) (1/1)
Nose 1 (1/47) (1/1)
Oral cavity 1 (1/482) Image Only
Skin 1 (1/482) (1/1)
Spinal cord 1 (1/46) (1/1)
Tail 1 (1/482) (1/1)
Tail somite 1 (1/482) Image Only


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Gross Morphology Embryo E9.5
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Foxo1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Foxo1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Foxo1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene