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Genes Phenotypes Help, News, Blog

Gene: Scly MGI:1355310

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
selenocysteine lyase
Synonyms:
Selenocysteine reductase,  Scly1,  Scly2,  A930015N15Rik,  SCL

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Scly mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Scly by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Specific Language Impairment 2
Deficit in phonologic short-term memory OMIM:606712
Specific Language Impairment 1
Deficit in phonologic short-term memory OMIM:606711
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
7q11.23 duplication syndrome
Short attention span DECIPHER:43
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Microangiopathy And Leukoencephalopathy, Pontine, Autosomal Dominant
Cognitive impairment, Dementia OMIM:618564

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Scly

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Scly.

There are 7 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice. Nutrients (October 2019) Sclytm1a(KOMP)Wtsi PMC6893568
Sexual Dimorphism in the Selenocysteine Lyase Knockout Mouse. Nutrients (January 2018) Sclytm1a(KOMP)Wtsi PMC5852735
Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience (November 2015) Sclytm1a(KOMP)Wtsi PMC4649005
Diet-induced obesity in the selenocysteine lyase knockout mouse. Antioxidants & redox signaling (August 2015) Sclytm1a(KOMP)Wtsi PMC4589310
Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures. The Journal of biological chemistry (February 2014) Sclytm1a(KOMP)Wtsi PMC3975015
Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Molecular and cellular biology (August 2012) Sclytm1a(KOMP)Wtsi PMC3457337
Absence of selenoprotein P but not selenocysteine lyase results in severe neurological dysfunction. Genes, brain, and behavior (May 2012) Sclytm1a(KOMP)Wtsi PMC3389215

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sclytm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sclytm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Sclytm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Sclytm42197(L1L2_Pgk_PM) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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