Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased bone mineral content | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | 6.75×10-06 | ||
abnormal skin morphology | Hdgfl3em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
decreased grip strength | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | 1.46×10-07 | ||
increased exploration in new environment | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | 7.64×10-09 | ||
decreased body length | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | 4.44×10-05 | ||
abnormal eye morphology | Hdgfl3em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
decreased lean body mass | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | 1.01×10-05 | ||
increased total body fat amount | Hdgfl3em1(IMPC)Tcp | HOM | Early adult | 1.80×10-05 | ||
enlarged urinary bladder | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | 0.00 | ||
increased exploration in new environment | Hdgfl3em1(IMPC)Tcp | HOM | Middle aged adult | 9.32×10-05 | ||
decreased grip strength | Hdgfl3em1(IMPC)Tcp | HOM | Early adult | 3.81×10-05 | ||
hyperactivity | Hdgfl3em1(IMPC)Tcp | HOM | Early adult | 1.77×10-07 | ||
decreased grip strength | Hdgfl3em1(IMPC)Tcp | HOM | Middle aged adult | 2.49×10-05 | ||
decreased lean body mass | Hdgfl3em1(IMPC)Tcp | HOM | Early adult | 4.19×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Hdgfl3 by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
Phenotype | Allele | Zygosity | Sex | Life Stage |
---|---|---|---|---|
Eye - MPATH pathological process term atrophy | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | |
Eye - MPATH pathological entity term epithelial hyperplasia | Hdgfl3em1(IMPC)Tcp | HOM | Late adult | |
Eye - MPATH pathological process term developmental dysplasia | Hdgfl3em1(IMPC)Tcp | HOM | Late adult |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Hdgfl3em1(IMPC)Tcp | Exon Deletion | Mice, Tissue |
Hdgfl3tm114221(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter