Gene: Parg

Order

Name poly (ADP-ribose) glycohydrolase

Status ES CellsMice
tm2a
Mice
tm2b
phenotype data available

Links MGI:1347094    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Parg

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Parg data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Pargtm2b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Pargtm2b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
hydrometra Pargtm2b(KOMP)Mbp HET Female postnatal 0.0
preweaning lethality, complete penetrance Pargtm2b(KOMP)Mbp HOM Female Male n/a 0.0
small superior vagus ganglion Pargtm2b(KOMP)Mbp HET Female postnatal 0.0
decreased leukocyte cell number Pargtm2b(KOMP)Mbp HET Female Male postnatal 1.29E-13

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (1/2)
Aorta 2 No (1/562) (1/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562) (1/2)
Cerebral cortex 2 No (5/562) (1/2)
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (1/2)
Hypothalamus 2 No (4/562) (1/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (1/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (1/2)
Submandibular gland 2 No (1/104)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    endocrine system
    digestive system
    cardiovascular system
    nervous system
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (2/2)
Dorsal root ganglion 1 (1/45)
Ear 2 (1/482)
Embryo 2 (1/482) (2/2)
Eye 2 (1/482) (1/2)
Foot 2 (1/482) (1/2)
Forebrain 2 (1/482) (1/2)
Forelimb 2 (1/482) (1/2)
Fronto-nasal process 1 (1/46)
Hand 2 (1/482) (1/2)
Head 2 (5/482) (2/2)
Heart 2 (1/482) (1/2)
Hindbrain 2 (6/482) (2/2)
Hindlimb 2 (1/482) (1/2)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482) (1/2)
Maxillary process 2 (1/482) (1/2)
Midbrain 2 (1/482) (1/2)
Nose 1 (1/47)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Spinal cord 1 (1/46) (1/1)
Tail 2 (1/482) (1/2)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    20 Images
  • X-ray: XRay Images Lateral Orientation
    20 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Combined SHIRPA and Dysmorphology
    2 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Pargtm2a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Pargtm2b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Paraffin-embedded Sections
Fixed Tissue
Pargtm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene