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Gene: Orc4 MGI:1347043

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Gene Summary

Name:
origin recognition complex, subunit 4
Synonyms:
Orc4,  Orc4l,  Orc4P,  mMmORC4

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal tail movements Orc4tm1a(EUCOMM)Wtsi HET   Early adult 3.68×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Orc4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Orc4 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Meier-Gorlin Syndrome 2
OMIM:613800
Ear-Patella-Short Stature Syndrome
ORPHA:2554

The table below shows human diseases predicted to be associated to Orc4 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Meier-Gorlin Syndrome 2
OMIM:613800
Ear-Patella-Short Stature Syndrome
ORPHA:2554

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Orc4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Orc4.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication†. Biology of reproduction (April 2022) Orc4tm1a(EUCOMM)Wtsi PMC9040667

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Orc4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Orc4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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