Gene: Map3k10

Name mitogen-activated protein kinase kinase kinase 10

Synonyms
  • mixed lineage kinase 2
  • serine/threonine kinase
  • Mlk2
  • MKN28 kinase
  • MKN28 derived nonreceptor_type

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1346879   Ensembl Gene   Ensembl Orthologs   IDG

Viability Homozygous - Viable

Phenotype associations for Map3k10

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Map3k10 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal bone structure Map3k10tm1b(EUCOMM)Hmgu HOM Male postnatal 1.12E-5
increased circulating HDL cholesterol level Map3k10tm1b(EUCOMM)Hmgu HOM Male postnatal 2.99E-5
decreased bone mineral content Map3k10tm1b(EUCOMM)Hmgu HOM Male postnatal 3.33E-5
decreased heart left ventricle size Map3k10tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.45E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Blood 2 No
Bone 2 No (1/539)
Bone marrow 2 No
Brain 2 No (5/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No (1/2)
Cartilage tissue 2 No (1/562)
Cecum 2 No (1/355)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Chest bone 2 No
Colon 2 No (1/99)
Cranium 2 No
Diaphragm 2 No
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Gall bladder 2 No
Harderian gland 2 No
Heart 2 No (3/562) (2/2)
Hindlimb 2 No
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (19/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Main olfactory bulb 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Olfactory lobe 2 No (4/393)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Parotid gland 2 No
Penis 2 No
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Sciatic nerve 2 No
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Stomach pyloric region 2 No
Striatum 2 No (4/562)
Sublingual gland 2 No
Submandibular gland 2 No (1/104)
Testis 2 No (3/562)
Thymus 2 No
Thyroid gland 2 No (16/562)
Tongue 2 No
Trachea 2 No (3/562)
Trigeminal V nerve 2 No
Urinary bladder 2 No
Uterus 2 No (2/562)
Vagina 2 No
Vas deferens 2 No (1/361)
Vascular system 2 No (1/393)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    cardiovascular system
    set of connective tissues
    adipose tissue
    trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    3 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Map3k10tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Map3k10tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Map3k10tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette)
Vector
Gene