Gene: Map3k10
Name mitogen-activated protein kinase kinase kinase 10
Synonyms
- mixed lineage kinase 2
- serine/threonine kinase
- Mlk2
- MKN28 kinase
- MKN28 derived nonreceptor_type
Status
ES CellsMice
tm1aMice
tm1bphenotype data available
Links MGI:1346879 Ensembl Gene Ensembl Orthologs IDG
Viability Homozygous - Viable
Phenotype associations for Map3k10
All Phenotypes Summary
Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Map3k10 data for that phenotype.
Significant Phenotypes
| System | Phenotype | Allele | Zyg | Sex | Life Stage | P Value | Data |
|---|---|---|---|---|---|---|---|
|
|
abnormal bone structure | Map3k10tm1b(EUCOMM)Hmgu | HOM |
|
postnatal | 1.12E-5 | |
|
|
increased circulating HDL cholesterol level | Map3k10tm1b(EUCOMM)Hmgu | HOM |
|
postnatal | 2.99E-5 | |
|
|
decreased bone mineral content | Map3k10tm1b(EUCOMM)Hmgu | HOM |
|
postnatal | 3.33E-5 | |
|
|
decreased heart left ventricle size | Map3k10tm1b(EUCOMM)Hmgu | HOM |
|
postnatal | 5.45E-5 |
Expression
IMPC lacZ Expression Data
Show expression table
Expression No Expression No Tissue Available Ambiguous
Show Wildtype Expression
| Anatomy | #HET Specimens | HOM Images? | WT Expr | Mutant Expr | Images |
|---|---|---|---|---|---|
| Adrenal gland | 2 | No | (5/393) | ||
| Aorta | 2 | No | (1/562) | ||
| Blood | 2 | No | |||
| Bone | 2 | No | (1/539) | ||
| Bone marrow | 2 | No | |||
| Brain | 2 | No | (5/562) | ||
| Brainstem | 2 | No | (4/562) | ||
| Brown adipose tissue | 2 | No | (1/2) | ||
| Cartilage tissue | 2 | No | (1/562) | ||
| Cecum | 2 | No | (1/355) | ||
| Cerebellum | 2 | No | (4/562) | ||
| Cerebral cortex | 2 | No | (5/562) | ||
| Chest bone | 2 | No | |||
| Colon | 2 | No | (1/99) | ||
| Cranium | 2 | No | |||
| Diaphragm | 2 | No | |||
| Epididymis | 2 | No | (4/106) | ||
| Esophagus | 2 | No | (2/393) | ||
| Eye | 2 | No | (1/562) | ||
| Gall bladder | 2 | No | |||
| Harderian gland | 2 | No | |||
| Heart | 2 | No | (3/562) | (2/2) | |
| Hindlimb | 2 | No | |||
| Hippocampus | 2 | No | (5/562) | ||
| Hypothalamus | 2 | No | (4/562) | ||
| Kidney | 2 | No | (19/562) | ||
| Large intestine | 2 | No | (12/562) | ||
| Liver | 2 | No | |||
| Lower urinary tract | 2 | No | (3/562) | ||
| Lung | 2 | No | (3/562) | ||
| Lymph node | 2 | No | (1/562) | ||
| Main olfactory bulb | 2 | No | |||
| Mammary gland | 2 | No | |||
| Mesenteric lymph node | 2 | No | |||
| Olfactory lobe | 2 | No | (4/393) | ||
| Oral epithelium | 2 | No | |||
| Ovary | 2 | No | (1/562) | ||
| Oviduct | 2 | No | (2/562) | ||
| Pancreas | 2 | No | (6/562) | ||
| Parathyroid gland | 2 | No | (2/540) | ||
| Parotid gland | 2 | No | |||
| Penis | 2 | No | |||
| Peripheral nervous system | 2 | No | (3/562) | ||
| Peyer's patch | 2 | No | (1/393) | ||
| Pituitary gland | 2 | No | (1/562) | ||
| Prostate gland | 2 | No | (5/562) | ||
| Sciatic nerve | 2 | No | |||
| Skeletal muscle | 2 | No | |||
| Skin | 2 | No | (1/562) | ||
| Small intestine | 2 | No | (11/562) | ||
| Spinal cord | 2 | No | (3/562) | ||
| Spleen | 2 | No | (4/562) | ||
| Stomach | 2 | No | (9/562) | ||
| Stomach pyloric region | 2 | No | |||
| Striatum | 2 | No | (4/562) | ||
| Sublingual gland | 2 | No | |||
| Submandibular gland | 2 | No | (1/104) | ||
| Testis | 2 | No | (3/562) | ||
| Thymus | 2 | No | |||
| Thyroid gland | 2 | No | (16/562) | ||
| Tongue | 2 | No | |||
| Trachea | 2 | No | (3/562) | ||
| Trigeminal V nerve | 2 | No | |||
| Urinary bladder | 2 | No | |||
| Uterus | 2 | No | (2/562) | ||
| Vagina | 2 | No | |||
| Vas deferens | 2 | No | (1/361) | ||
| Vascular system | 2 | No | (1/393) | ||
| Vesicular gland | 2 | No | |||
| White adipose tissue | 2 | No |
No expression image was found for this adult tab
No expression data was found for this embryo tab
Associated Images
Associated Images
-
X-ray: XRay Images Lateral Orientation
10 Images
-
X-ray: XRay Images Dorso Ventral
10 Images
-
Adult LacZ: LacZ Images Wholemount
3 Images
Order Mouse and ES Cells
| Targeting Detail | Product Ordering | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MGI Allele | Allele Type | Type Map Seq | Vector | ES Cell | Mouse | Tissue Enquiry | ||||||
| Map3k10tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) |
|
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| Map3k10tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (post-Cre) |
|
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| Map3k10tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) |
|
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