Gene: Map3k7

Name mitogen-activated protein kinase kinase kinase 7

Synonyms
  • transforming growth factor beta-activated kinase 1
  • TAK1
  • transforming growth factor-beta-activated kinase 1
  • Tak1
  • TGF-beta activated kinase 1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1346877   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Map3k7

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Map3k7 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to tooth bud stage Map3k7tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Map3k7tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
abnormal lens morphology Map3k7tm1b(EUCOMM)Wtsi HET Female postnatal 3.87E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354) (2/2)
Aorta 2 No (2/530) (2/2)
Bone 2 No (1/515) (2/2)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530) (2/2)
Cerebellum 2 No (6/530) (2/2)
Cerebral cortex 2 No (6/530) (2/2)
Esophagus 2 No (1/354) (2/2)
Eye 2 No (1/530) (2/2)
Gall bladder 2 No
Heart 2 No (4/530) (2/2)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/530) (2/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530)
Mammary gland 2 No
Olfactory lobe 2 No (3/354) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/530)
Oviduct 2 No (1/530)
Pancreas 2 No (2/530) (2/2)
Parathyroid gland 2 No (2/516) (2/2)
Peripheral nervous system 2 No (4/530) (2/2)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530) (2/2)
Prostate gland 2 No (3/530) (1/2)
Skeletal muscle 2 No
Skin 2 No (2/530) (2/2)
Small intestine 2 No (5/530) (2/2)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530) (2/2)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530) (2/2)
Uterus 2 No (1/530)
Vascular system 2 No (1/354) (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ exocrine system integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/413) (1/2)
Ear 2 (1/2)
Embryo 2 (2/2)
Eye 2 (1/2)
Foot 2 Image Only
Forebrain 2 (1/2)
Forelimb 2 (1/2)
Hand 2 Image Only
Head 2 (4/413) (1/2)
Heart 2 (1/2)
Hindbrain 2 (5/413) (1/2)
Hindlimb 2 (1/2)
Liver 2 (1/2)
Lung 2 (1/2)
Mandibular process 2 (1/2)
Maxillary process 2 (1/2)
Midbrain 2 (1/2)
Oral cavity 2 (1/2)
Skin 2 (1/2)
Tail 2 (1/2)
Tail somite 2 (1/2)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Echo: M-Mode Images
    20 Images
  • Adult LacZ: LacZ Images Wholemount
    19 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Map3k7tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Map3k7tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Map3k7tm33755(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene