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Gene: Trex2 MGI:1346343

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
three prime repair exonuclease 2
Synonyms:
N/A

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Trex2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Trex2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Dermatitis Herpetiformis, Familial
Pruritus OMIM:601230
Pruritus, Hereditary Localized
Pruritus OMIM:177100
Lichen Amyloidosis
Pruritus ORPHA:49804
Linear Atrophoderma Of Moulin
Pruritus, Inflammatory abnormality of the skin ORPHA:140933
Congenital Panfollicular Nevus
Pruritus, Hamartoma ORPHA:139414
Ichthyosis, Lamellar, Autosomal Dominant
Pruritus OMIM:146750
Dowling-Degos Disease 4
Pruritus OMIM:615696
Disseminated Superficial Actinic Porokeratosis
Pruritus, Squamous cell carcinoma ORPHA:79152
Amyloidosis, Primary Localized Cutaneous, 2
Pruritus OMIM:613955
Erythrokeratodermia Variabilis Et Progressiva 6
Pruritus, Superficial dermal perivascular inflammatory infiltrate OMIM:618531
Hereditary Leiomyomatosis And Renal Cell Cancer
Barrett esophagus, Multiple cutaneous leiomyomas, Vaginal neoplasm, Pruritus, Esophageal neoplasm... ORPHA:523
Mycosis Fungoides
Psoriasiform dermatitis, Eczema, Pruritus, Lymphoma, Neoplasm of the skin OMIM:254400
Epidermolysis Bullosa Dystrophica, Pretibial
Pruritus OMIM:131850
Epidermolysis Bullosa Simplex 5D, Generalized Intermediate, Autosomal Recessive
Pruritus OMIM:616487
Peeling Skin Syndrome 3
Pruritus OMIM:616265
Hyperkeratosis Lenticularis Perstans
Pruritus, Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Bullous Diffuse Cutaneous Mastocytosis
Pruritus, Cutaneous mastocytosis, Erythroderma ORPHA:280785
Pilomatrixoma
Pruritus, Pilomatrixoma, Neoplasm of head and neck ORPHA:91414
Chronic Actinic Dermatitis
Late onset atopic dermatitis, Eczema, Pruritus, Erythroderma, Actinic keratosis ORPHA:330064
Bullous Lichen Planus
Pruritus ORPHA:33408
Amyloidosis, Primary Localized Cutaneous, 1
Pruritus OMIM:105250

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trex2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trex2.

No publications found that use IMPC mice or data for Trex2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trex2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Trex2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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