Gene: Arih2

Order

Name ariadne RBR E3 ubiquitin protein ligase 2

Synonyms TRIAD1

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1344361    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Arih2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Arih2 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Arih2tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
abnormal embryo size Arih2tm1.1(KOMP)Vlcg HET Female embryonic day 9.5 0.0
abnormal heart morphology Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 0.0
abnormal kidney morphology Arih2tm1.1(KOMP)Vlcg HET Male postnatal 0.0
abnormal seminal vesicle morphology Arih2tm1.1(KOMP)Vlcg HET Male postnatal 0.0
abnormal skin morphology Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 0.0
abnormal urinary bladder morphology Arih2tm1.1(KOMP)Vlcg HET Male postnatal 0.0
cystolithiasis Arih2tm1.1(KOMP)Vlcg HET Male postnatal 0.0
embryonic growth retardation Arih2tm1.1(KOMP)Vlcg HET Female embryonic day 9.5 0.0
embryonic growth retardation Arih2tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Arih2tm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
enlarged heart Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 0.0
polycystic kidney Arih2tm1.1(KOMP)Vlcg HET Male postnatal 0.0
preweaning lethality, complete penetrance Arih2tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
thick skin Arih2tm1.1(KOMP)Vlcg HET Male postnatal 0.0
decreased circulating insulin level Arih2tm1.1(KOMP)Vlcg HET Male postnatal 2.33E-8
decreased circulating triglyceride level Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 1.28E-7
decreased prepulse inhibition Arih2tm1.1(KOMP)Vlcg HET Male postnatal 1.61E-7
decreased blood urea nitrogen level Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 2.33E-7
decreased startle reflex Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 1.55E-6
abnormal bone structure Arih2tm1.1(KOMP)Vlcg HET Male postnatal 2.5E-5
prolonged PR interval Arih2tm1.1(KOMP)Vlcg HET Female Male postnatal 7.89E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Blood 2 No (2/2)
Bone marrow 2 No (2/2)
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No
Cecum 2 No (12/383) (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No
Chest bone 2 No
Colon 2 No (12/127) (2/2)
Diaphragm 2 No (2/2)
Duodenum 2 No (2/127) (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Gall bladder 2 No
Gonadal fat pad 2 No (2/2)
Harderian gland 2 No (2/2)
Heart 2 No
Hindlimb 2 No
Hippocampus 2 No
Hypothalamus 2 No
Ileum 2 No (14/127) (2/2)
Jejunum 2 No (6/127)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No (2/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No (1/2)
Mesenteric lymph node 2 No (2/2)
Mesenteric adipose tissue 2 No (2/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (1/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (1/2)
Parotid gland 2 No (2/2)
Penis 2 No (1/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584) (1/2)
Quadriceps 2 No (2/2)
Sciatic nerve 2 No (2/2)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Stomach pyloric region 2 No
Striatum 2 No
Sublingual gland 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Tongue 2 No (5/127) (2/2)
Trachea 2 No (2/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vagina 2 No
Vas deferens 2 No (15/388) (1/2)
Vascular system 2 No
Vesicular gland 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system limb digestive system cardiovascular system set of connective tissues reproductive system adipose tissue musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2 (1/51) (2/2)
Brain 8 (6/485) (2/8)
Central nervous system ganglion 2 (1/51) (2/2)
Ear 8 (1/485) (2/8)
Embryo 8 (1/485) (2/8)
Eye 8 (1/485) (2/8)
Foot 8 (1/485) (2/8)
Forebrain 8 (1/485) (2/8)
Forelimb 8 (1/485) (2/8)
Gut 2 (1/50) (2/2)
Hand 8 (1/485) (2/8)
Head 8 (5/485) (2/8)
Heart 8 (1/485) (2/8)
Hindbrain 8 (6/485) (2/8)
Hindlimb 8 (1/485) (2/8)
Liver 8 (1/485) (2/8)
Lung 8 (1/485) (2/8)
Mandibular process 8 (1/485) (2/8)
Maxillary process 8 (1/485) (2/8)
Midbrain 8 (1/485) (2/8)
Nose 2 (1/51) (2/2)
Oral cavity 8 (1/485) (2/8)
2 (7/25) (2/2)
Skeleton 2 (1/51) (2/2)
Skin 8 (1/485) (2/8)
Spinal cord 2 (1/50) (2/2)
Tail 8 (1/485) (2/8)
Tail somite 8 (1/485) (2/8)
Trachea 2 (1/50) (2/2)
Urinary system 2 (1/50) (2/2)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Embryo LacZ: LacZ images wholemount
    23 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Arih2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Arih2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Arih2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue
Arih2tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene