Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Adnp by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Adnp Syndrome | Umbilical hernia | ORPHA:404448 | |
Helsmoortel-Van Der Aa Syndrome | OMIM:615873 |
The table below shows human diseases predicted to be associated to Adnp by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Neural Tube Defects, Folate-Sensitive | Spinal dysraphism | OMIM:601634 | |
Spina Bifida-Hypospadias Syndrome | Spina bifida, Spinal dysraphism | ORPHA:3176 | |
Anencephaly 1 | Anencephaly, Spina bifida | OMIM:206500 | |
Adnp Syndrome | Umbilical hernia | ORPHA:404448 | |
Helsmoortel-Van Der Aa Syndrome | OMIM:615873 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adnp.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits. | Molecular psychiatry (June 2023) | Adnptm1c(KOMP)Wtsi Adnptm1a(KOMP)Wtsi Adnptm1d(KOMP)Wtsi | 37365244 |
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation. | Immunity (June 2023) | Adnptm1c(KOMP)Wtsi Adnptm1a(KOMP)Wtsi | 37285842 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Adnptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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