Gene: Prkab1

Order

Name protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms 1300015D22Rik

Status ES CellsMice
tm1a
Mice
em1
Mice
tm1b
Mice
em1
Mice
em2
phenotype data available

Links MGI:1336167    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Prkab1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Prkab1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Liver - hyperplasia Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 0.0
Spleen - hyperplasia Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 0.0
Sternum - developmental and structural abnormality Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
abnormal heart morphology Prkab1em2(IMPC)Mbp HOM Male postnatal 0.0
abnormal spleen morphology Prkab1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
abnormal thymus morphology Prkab1em2(IMPC)Mbp HOM Male postnatal 0.0
anophthalmia Prkab1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
decreased mean corpuscular volume Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
enlarged heart Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 0.0
enlarged heart Prkab1em2(IMPC)Mbp HOM Male postnatal 0.0
enlarged spleen Prkab1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
enlarged thymus Prkab1em2(IMPC)Mbp HOM Male postnatal 0.0
increased memory-marker CD4-negative NK T cell number Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased memory-marker gamma-delta T cell number Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased red blood cell distribution width Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
preweaning lethality, incomplete penetrance Prkab1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased mean corpuscular hemoglobin Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.6E-40
increased circulating bilirubin level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.6E-21
decreased mean corpuscular hemoglobin concentration Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 8.29E-16
decreased hematocrit Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.79E-13
increased red blood cell distribution width Prkab1em2(IMPC)Mbp HOM Female Male postnatal 2.16E-13
decreased hemoglobin content Prkab1tm1a(KOMP)Wtsi HOM Female Male postnatal 1.93E-12
abnormal retinal blood vessel morphology Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.22E-12
abnormal retinal vasculature morphology Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.22E-12
decreased hemoglobin content Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.24E-12
decreased circulating HDL cholesterol level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.38E-10
decreased circulating cholesterol level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.81E-10
increased glycosylated hemoglobin level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.52E-10
decreased mean corpuscular volume Prkab1em2(IMPC)Mbp HOM Female Male postnatal 3.06E-9
decreased circulating iron level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.64E-8
hypoactivity Prkab1tm1b(KOMP)Wtsi HOM Female postnatal 1.95E-8
decreased total retina thickness Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.28E-8
increased circulating bilirubin level Prkab1tm1a(KOMP)Wtsi HOM Female Male postnatal 2.36E-8
decreased circulating LDL cholesterol level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.59E-8
decreased mean corpuscular hemoglobin Prkab1em2(IMPC)Mbp HOM Female Male postnatal 6.07E-7
abnormal spine curvature Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 6.08E-7
kyphosis Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 6.08E-7
decreased circulating amylase level Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.06E-6
increased spleen weight Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.13E-6
decreased caudal vertebrae number Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.2E-6
impaired glucose tolerance Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.55E-6
decreased leukocyte cell number Prkab1em2(IMPC)Mbp HOM Female postnatal 4.18E-6
decreased lymphocyte cell number Prkab1em2(IMPC)Mbp HOM Female Male postnatal 5.48E-6
decreased hematocrit Prkab1tm1a(KOMP)Wtsi HOM Female Male postnatal 8.86E-6
decreased erythrocyte cell number Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.03E-5
increased fluid intake Prkab1tm1b(KOMP)Wtsi HOM Female postnatal 1.13E-5
increased mean platelet volume Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.15E-5
increased spleen weight Prkab1em1(IMPC)Bay HOM Female postnatal 1.43E-5
abnormal retinal blood vessel pattern Prkab1tm1a(KOMP)Wtsi HOM Female postnatal 2.0E-5
abnormal retinal vasculature morphology Prkab1tm1a(KOMP)Wtsi HOM Female postnatal 2.0E-5
increased bone mineral density Prkab1tm1b(KOMP)Wtsi HET Female postnatal 2.48E-5
decreased total body fat amount Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 4.46E-5
increased grip strength Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.23E-5
shortened RR interval Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.71E-5
decreased lean body mass Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 5.88E-5
decreased body length Prkab1tm1b(KOMP)Wtsi HOM Female Male postnatal 6.93E-5
abnormal behavior Prkab1tm1b(KOMP)Wtsi HOM Male postnatal 7.68E-5
decreased mean corpuscular volume Prkab1tm1a(KOMP)Wtsi HOM Female Male postnatal 8.32E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (4/4)
Adrenal gland 15 Yes (2/415) (14/17)
Aorta 19 Yes (10/21)
Blood 2 No
Blood vessel 4 No
Bone 13 Yes (4/15)
Bone marrow 2 No
Brain 19 Yes (18/21)
Brainstem 19 No (15/21)
Brown adipose tissue 4 No
Brown adipose tissue 13 No (2/15)
Cartilage tissue 19 No (18/21)
Cecum 8 Yes (12/383) (7/10)
Cerebellum 19 No (18/21)
Cerebral cortex 19 No (16/21)
Chest bone 6 Yes (6/8)
Colon 6 No (12/127) (8/8)
Cranium 4 No
Diaphragm 6 Yes (6/8)
Duodenum 6 Yes (2/127) (7/8)
Epididymis 8 Yes (18/134) (2/10)
Esophagus 15 Yes (7/415) (14/17)
Eye 19 Yes (10/21)
Gall bladder 15 Yes (4/17)
Gonadal fat pad 6 No
Harderian gland 6 Yes
Heart 19 Yes (14/21)
Hindlimb 6 Yes (6/8)
Hippocampus 19 No (16/21)
Hypothalamus 19 No (16/21)
Ileum 6 Yes (14/127) (7/8)
Jejunum 6 Yes (6/127) (6/8)
Kidney 19 Yes (18/584) (18/21)
Large intestine 19 Yes (10/584) (14/21)
Liver 19 Yes (13/21)
Lower urinary tract 19 No (12/21)
Lung 19 Yes (11/21)
Lymph node 19 Yes (2/21)
Main olfactory bulb 4 Yes (6/6)
Mammary gland 19 Yes (3/21)
Mesenteric lymph node 6 Yes
Mesenteric adipose tissue 6 Yes
Midbrain 8 No (10/10)
Esophagus 4 No (2/4)
Olfactory lobe 15 No (15/17)
Olfactory lobe 4 No (2/4)
Oral epithelium 9 Yes (6/11)
Ovary 19 Yes (1/584) (8/21)
Oviduct 19 Yes (8/21)
Pancreas 19 Yes (5/584) (11/21)
Parathyroid gland 15 Yes (7/17)
Parotid gland 6 Yes
Penis 6 Yes (4/8)
Peripheral nervous system 19 No (10/21)
Peyer's patch 4 No
Peyer's patch 15 No (1/17)
Pituitary gland 19 Yes (15/21)
Prostate gland 19 Yes (12/584) (4/21)
Quadriceps 6 Yes (6/8)
Sciatic nerve 6 Yes
Skeletal muscle 15 No (13/17)
Skeletal muscle tissue 4 No (4/4)
Skin 19 Yes (13/21)
Small intestine 19 No (9/584) (14/21)
Spinal cord 19 Yes (20/21)
Spleen 19 Yes (2/584) (2/21)
Stomach 19 Yes (12/584) (17/21)
Stomach pyloric region 6 No
Striatum 19 No (14/21)
Sublingual gland 6 Yes
Submandibular gland 8 Yes (2/132) (3/10)
Testis 19 Yes (2/584) (9/21)
Thalamus 6 No (8/8)
Thymus 19 Yes (16/21)
Thyroid gland 19 Yes (15/584) (6/21)
Tongue 7 Yes (5/127) (9/9)
Trachea 19 Yes (18/21)
Trigeminal V nerve 8 Yes (10/10)
Urinary bladder 8 Yes (10/10)
Uterus 19 Yes (8/21)
Vagina 6 Yes (1/8)
Vas deferens 8 No (15/388) (1/10)
Vascular system 15 No (4/17)
Vesicular gland 8 Yes
White adipose tissue 19 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • limb(6)
    Hindlimb expression
    MA:0000026

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 13 (6/485) (15/16)
Dorsal root ganglion 1 (1/47) Image Only
Ear 13 (1/485) (4/16)
Embryo 13 (1/485) (15/16)
Eye 13 (1/485) (15/16)
Foot 13 (1/485) (7/16)
Forearm 8 (1/282)
Forebrain 13 (1/485) (15/16)
Forelimb 13 (1/485) (7/16)
Fronto-nasal process 1 (1/48) Image Only
Hand 13 (1/485) (7/16)
Head 13 (5/485) (15/16)
Heart 13 (1/485) (12/16)
Hindbrain 13 (6/485) (15/16)
Hindlimb 13 (1/485) (7/16)
Liver 13 (1/485) (3/16)
Lower leg 8 (1/282)
Lung 13 (1/485) (3/16)
Mandibular process 13 (1/485) (4/16)
Maxillary process 13 (1/485) (4/16)
Midbrain 13 (1/485) (7/16)
Nose 1 (1/51) (1/1)
Oral cavity 13 (1/485) (3/16)
Skin 13 (1/485) (4/16)
Spinal cord 1 (1/50) (1/1)
Tail 13 (1/485) (7/16)
Tail somite 13 (1/485) (7/16)
Upper arm 8 (1/282)
Upper leg 8 (1/282)


Secondary lacZ Expression Data
postnatal mouse (40)
  • Prkab1Gt(RRR454)Byg
    eye, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    peripheral nervous system, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    liver, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI

show all 40 images

trunk (26)
  • Prkab1Gt(RRR454)Byg
    liver, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    ovary, uterus, oviduct, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI

show all 26 images

nervous system (10)
  • Prkab1Gt(RRR454)Byg
    peripheral nervous system, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    pituitary gland, peripheral nervous system, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    brain, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI

show all 10 images

digestive system (6)
  • Prkab1Gt(RRR454)Byg
    liver, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    liver, gall bladder, HET, Female, WTSI

show all 6 images

endocrine system (4)
  • Prkab1tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    trachea, parathyroid gland, thyroid gland, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    parathyroid gland, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
urinary system (4)
  • Prkab1tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    kidney, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI
musculoskeletal system (3)
  • Prkab1tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    rib, cartilage tissue, HET, Male, WTSI
reproductive system (3)
  • Prkab1tm1a(KOMP)Wtsi
    ovary, uterus, oviduct, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    oviduct, HET, Female, WTSI
cardiovascular system (2)
  • Prkab1tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    aorta, HET, Female, WTSI
immune system (2)
  • Prkab1tm1a(KOMP)Wtsi
    thymus, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    thymus, HET, Female, WTSI
respiratory system (2)
  • Prkab1tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    trachea, parathyroid gland, thyroid gland, HET, Female, WTSI
sensory organ (2)
  • Prkab1Gt(RRR454)Byg
    eye, HET, Female, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    eye, HET, Female, WTSI
integumental system (1)
  • Prkab1tm1a(KOMP)Wtsi
    skin, HET, Female, WTSI
set of connective tissues (1)
  • Prkab1tm1b(KOMP)Wtsi
    rib, cartilage tissue, HET, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    54 Images
  • X-ray: XRay Images Lateral Orientation
    143 Images
  • X-ray: XRay Images Skull Lateral Orientation
    50 Images
  • X-ray: XRay Images Forepaw
    39 Images
  • X-ray: XRay Images Dorso Ventral
    183 Images
  • Electroretinography: Rod waveform (pdf format)
    4 Images
  • Electroretinography: Cone waveform (pdf format)
    4 Images
  • Sleep Wake: Wake state (bmp file)
    25 Images
  • Embryo LacZ: LacZ images wholemount
    102 Images
  • Adult LacZ: LacZ Images Wholemount
    621 Images
Legacy Phenotype Associated Images
Xray (340)
  • Prkab1Gt(RRR454)Byg
    head, WT, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    body, WT, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    body, WT, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    forearm, WT, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    head, WT, Female, WTSI

show all 340 images

Eye Morphology (10)
  • Prkab1Gt(RRR454)Byg
    eye, cataracts, HET, Male, WTSI
  • Prkab1Gt(RRR454)Byg
    eye, cataracts, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    eye, cataracts, HET, Male, WTSI
  • Prkab1Gt(RRR454)Byg
    eye, cataracts, HET, Male, WTSI
  • Prkab1tm1a(KOMP)Wtsi
    eye, corneal opacity, corneal vascularization, HOM, Female, WTSI

show all 10 images

Skin Histopathology (6)
  • Prkab1Gt(RRR454)Byg
    back skin, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    back skin, WT, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    back skin, HET, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    back skin, WT, Female, WTSI
  • Prkab1Gt(RRR454)Byg
    back skin, HET, Female, WTSI

show all 6 images

Histology Slide (5)
  • Prkab1tm1b(KOMP)Wtsi
    TS20 head, HET, Male, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    TS20 chorioallantoic placenta, HET, Male, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    TS20 oral cavity, HET, Male, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    TS20 hindbrain, HET, Male, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    TS20 skin, HET, Male, WTSI
Dysmorphology (4)
  • Prkab1Gt(RRR454)Byg
    abnormal ear rotation, pinna, HET, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Prkab1tm1b(KOMP)Wtsi
    tail, WT, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Prkab1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Prkab1em1(IMPC)J Exon Deletion
Vector
Gene
Prkab1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Prkab1em1(IMPC)Bay Exon Deletion
Vector
Gene
Prkab1em2(IMPC)Mbp Indel causing a Frameshift Mutation
Vector
Gene
Fixed Tissue
Prkab1tm301228(L1L2_Bact_P)
Vector
Gene
Prkab1tm37294(L1L2_Bact_P)
Vector
Gene