Genes Phenotypes Help, News, Blog

Please enable javascript if you want to log in to follow or stop following this gene.

Gene: Cyth1 MGI:1334257

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

cytohesin 1

Synonyms:

CLM1, Pscd1, CTH-1

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cyth1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Cyth1 (0 diseases)
Human diseases predicted to be associated with Cyth1 (217 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cyth1 by phenotypic similarity.

Disease	Matching phenotypes	Source
Pelizaeus-Merzbacher disease	Abnormal CNS myelination, Leukodystrophy	DECIPHER:38
Pelizaeus-Merzbacher Disease, Transitional Form	CNS hypomyelination	ORPHA:280224
Hypomyelination-Congenital Cataract Syndrome	Cerebral hypomyelination	ORPHA:85163
Hypomyelination-Hypogonadotropic Hypogonadism-Hypodontia Syndrome	CNS hypomyelination	ORPHA:88637
Mitochondrial Complex Iv Deficiency, Nuclear Type 17	Cavitating leukodystrophy	OMIM:619061
Charcot-Marie-Tooth Disease, Type 4A	Basal lamina onion bulb formation, Decreased number of peripheral myelinated nerve fibers, CNS hy...	OMIM:214400
Null Syndrome	Demyelinating peripheral neuropathy, CNS hypomyelination, Peripheral demyelination	ORPHA:280234
Leukodystrophy, Hypomyelinating, 11	CNS hypomyelination, Leukodystrophy	OMIM:616494
Adult-onset autosomal dominant leukodystrophy (ADLD)	Leukodystrophy, Peripheral demyelination	DECIPHER:59
Cataracts, Hearing Impairment, Nephrotic Syndrome, And Enterocolitis 2	CNS hypomyelination	OMIM:620425
Developmental And Epileptic Encephalopathy 86	CNS hypomyelination	OMIM:618910
Leukodystrophy, Hypomyelinating, 23, With Ataxia, Deafness, Liver Dysfunction, And Dilated Cardiomyopathy	CNS hypomyelination	OMIM:619688
Spastic Ataxia 8, Autosomal Recessive, With Hypomyelinating Leukodystrophy	CNS hypomyelination, Leukodystrophy	OMIM:617560
Multiple Mitochondrial Dysfunctions Syndrome 4	Leukodystrophy	OMIM:616370
Methionine Adenosyltransferase I/Iii Deficiency	CNS demyelination, Peripheral demyelination	OMIM:250850
Leukodystrophy And Acquired Microcephaly With Or Without Dystonia	Leukodystrophy	OMIM:616763
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome	CNS hypomyelination, Cerebral hypomyelination	ORPHA:369939
Developmental And Epileptic Encephalopathy 79	CNS hypomyelination	OMIM:618559
Developmental And Epileptic Encephalopathy 78	CNS hypomyelination	OMIM:618557
Nkx6-2-Related Autosomal Recessive Hypomyelinating Leukodystrophy	CNS hypomyelination, Leukodystrophy	ORPHA:527497
Tremor, Hereditary Essential, 6	Leukodystrophy	OMIM:618866
Deafness, Dystonia, And Cerebral Hypomyelination	Cerebral hypomyelination	OMIM:300475
Neurodevelopmental Disorder With Neonatal Respiratory Insufficiency, Hypotonia, And Feeding Difficulties	CNS hypomyelination, Delayed CNS myelination	OMIM:616158
Leukodystrophy, Hypomyelinating, 22	CNS hypomyelination	OMIM:619328
Kaya-Barakat-Masson Syndrome	CNS hypomyelination	OMIM:619125
Developmental And Epileptic Encephalopathy 5	CNS hypomyelination	OMIM:613477
Leukodystrophy, Hypomyelinating, 5	CNS hypomyelination, Onion bulb formation, Leukodystrophy	OMIM:610532
Leukodystrophy, Childhood-Onset, Remitting	Leukodystrophy	OMIM:619864
Neurodevelopmental Disorder With Hearing Loss, Seizures, And Brain Abnormalities	CNS hypomyelination, Delayed CNS myelination	OMIM:616577
Leukoencephalopathy With Vanishing White Matter 1	CNS demyelination, Cerebral hypomyelination	OMIM:603896
Hypomyelination With Brainstem And Spinal Cord Involvement And Leg Spasticity	CNS hypomyelination	OMIM:615281
Autosomal Recessive Spastic Paraplegia Type 44	CNS hypomyelination	ORPHA:320401
Microcephaly, Progressive, With Seizures And Cerebral And Cerebellar Atrophy	CNS hypomyelination	OMIM:615760
Leukodystrophy, Hypomyelinating, 15	CNS hypomyelination, Leukodystrophy	OMIM:617951
Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism	CNS hypomyelination, Leukodystrophy	OMIM:607694
Leukoencephalopathy, Brain Calcifications, And Cysts	Leukodystrophy	OMIM:614561
Huppke-Brendel Syndrome	CNS hypomyelination	OMIM:614482
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures	CNS hypomyelination	OMIM:620023
Hereditary Methemoglobinemia	Delayed myelination, Cerebral hypomyelination	ORPHA:621
Peroxisome Biogenesis Disorder 11A (Zellweger)	CNS hypomyelination	OMIM:614883
Leukodystrophy, Hypomyelinating, 6	Leukodystrophy, Cerebral hypomyelination	OMIM:612438
Multiple Mitochondrial Dysfunctions Syndrome 5	Delayed myelination, Leukodystrophy	OMIM:617613
Spastic Paraplegia 44, Autosomal Recessive	CNS hypomyelination	OMIM:613206
Leukodystrophy, Hypomyelinating, 2	Demyelinating motor neuropathy, Leukodystrophy, Cerebral hypomyelination	OMIM:608804
Deafness, Congenital, And Adult-Onset Progressive Leukoencephalopathy	Leukodystrophy	OMIM:619196
Developmental And Epileptic Encephalopathy 93	CNS hypomyelination	OMIM:618012
Alg2-Cdg	Cerebral hypomyelination	ORPHA:79326
Ddost-Cdg	CNS hypomyelination	ORPHA:300536
Giant Axonal Neuropathy	CNS hypomyelination	ORPHA:643
Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism	CNS hypomyelination, Leukodystrophy, Cerebral hypomyelination	OMIM:614381
Neurodevelopmental Disorder With Language Delay And Seizures	CNS hypomyelination	OMIM:619908
Orofaciodigital Syndrome Xvii	CNS hypomyelination	OMIM:617926
Leukodystrophy, Hypomyelinating, 10	CNS hypomyelination, Leukodystrophy	OMIM:616420
Folinic Acid-Responsive Seizures	Delayed myelination, Cerebral hypomyelination	ORPHA:79097
Pelizaeus-Merzbacher Disease	CNS hypomyelination, Cerebral dysmyelination, Sudanophilic leukodystrophy, Abnormal CNS myelination	OMIM:312080
Spasticity, Childhood-Onset, With Hyperglycinemia	Leukodystrophy	OMIM:616859
Tremor-Ataxia-Central Hypomyelination Syndrome	CNS hypomyelination, Leukodystrophy	ORPHA:447896
Lissencephaly 8	Cerebral hypomyelination	OMIM:617255
Neurodevelopmental Disorder With Spasticity, Cataracts, And Cerebellar Hypoplasia	CNS hypomyelination	OMIM:619286
Developmental And Epileptic Encephalopathy 75	CNS hypomyelination	OMIM:618437
Developmental And Epileptic Encephalopathy 4	Cerebral hypomyelination, Delayed CNS myelination	OMIM:612164
Retinal Dystrophy With Leukodystrophy	CNS hypomyelination	OMIM:618863
Glutamine Deficiency, Congenital	CNS hypomyelination	OMIM:610015
Microcephaly-Capillary Malformation Syndrome	Delayed myelination, CNS hypomyelination	OMIM:614261
Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis	CNS hypomyelination, Delayed CNS myelination	OMIM:619260
4H Leukodystrophy	Cerebral hypomyelination	ORPHA:289494
Cerebellar Ataxia, Brain Abnormalities, And Cardiac Conduction Defects	CNS hypomyelination, Leukodystrophy	OMIM:619576
Neuropathy, Congenital Hypomyelinating, 3	CNS hypomyelination	OMIM:618186
Pycr2-Related Microcephaly-Progressive Leukoencephalopathy	CNS hypomyelination, Severe demyelination of the white matter	ORPHA:481152
Adenylosuccinase Deficiency	CNS hypomyelination, Cerebral hypomyelination	OMIM:103050
Neurodevelopmental Disorder With Microcephaly, Arthrogryposis, And Structural Brain Anomalies	CNS hypomyelination	OMIM:618622
Immunodeficiency 26 With Or Without Neurologic Abnormalities	CNS hypomyelination	OMIM:615966
Developmental And Epileptic Encephalopathy 29	CNS hypomyelination	OMIM:616339
Combined Oxidative Phosphorylation Deficiency 24	CNS hypomyelination	OMIM:616239
Pelizaeus-Merzbacher Disease In Female Carriers	CNS hypomyelination	ORPHA:280229
Combined Oxidative Phosphorylation Deficiency 11	Delayed myelination, CNS hypomyelination	OMIM:614922
Leukodystrophy, Hypomyelinating, 12	Delayed myelination, Cerebral hypomyelination	OMIM:616683
Developmental And Epileptic Encephalopathy 71	CNS demyelination	OMIM:618328
Combined Oxidative Phosphorylation Deficiency 53	CNS hypomyelination	OMIM:619423
Juvenile Amyotrophic Lateral Sclerosis	CNS hypomyelination, Amyotrophic lateral sclerosis	ORPHA:300605
Sandhoff Disease, Infantile Form	CNS hypomyelination	ORPHA:309155
Rars-Related Autosomal Recessive Hypomyelinating Leukodystrophy	Cerebral hypomyelination	ORPHA:438114
Combined Saposin Deficiency	CNS demyelination	OMIM:611721
S-Adenosylhomocysteine Hydrolase Deficiency	Delayed myelination, CNS hypomyelination	ORPHA:88618
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features	CNS hypomyelination	OMIM:618527
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures	CNS hypomyelination, Delayed CNS myelination	OMIM:619580
Developmental And Epileptic Encephalopathy 39 With Leukodystrophy	Cerebral hypomyelination	OMIM:612949
Pelizaeus-Merzbacher Disease, Connatal Form	Abnormal myelination, Cerebral hypomyelination	ORPHA:280210
Leukoencephalopathy, Cystic, Without Megalencephaly	Abnormal CNS myelination	OMIM:612951
Spastic Paraplegia-Intellectual Disability-Nystagmus-Obesity Syndrome	Abnormal CNS myelination	ORPHA:521390
Dermatoleukodystrophy	Leukodystrophy	OMIM:221790
Gaba-Transaminase Deficiency	Leukodystrophy	OMIM:613163
Peroxisomal Acyl-Coa Oxidase Deficiency	CNS demyelination, Leukodystrophy	OMIM:264470
Encephalopathy, Progressive, Early-Onset, With Brain Atrophy And Thin Corpus Callosum	CNS hypomyelination	OMIM:617193
Marbach-Rustad Progeroid Syndrome	CNS hypomyelination	OMIM:619322
Leukodystrophy, Hypomyelinating, 19, Transient Infantile	Leukodystrophy, Delayed CNS myelination	OMIM:618688
Pelizaeus-Merzbacher Disease, Classic Form	Cerebral hypomyelination	ORPHA:280219
Sandhoff Disease	CNS hypomyelination	OMIM:268800
Renal Tubular Acidosis, Distal, With Nephrocalcinosis, Short Stature, Impaired Intellectual Development, And Distinctive Facies	Abnormal CNS myelination	OMIM:611555
Epilepsy, Early-Onset, 2, With Or Without Developmental Delay	Delayed CNS myelination	OMIM:618832
Spinocerebellar Ataxia 23	CNS demyelination	OMIM:610245
Gastrointestinal Defects And Immunodeficiency Syndrome 2	CNS hypomyelination, Leukodystrophy	OMIM:619708
Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities	CNS hypomyelination	OMIM:618922
Mitochondrial Complex I Deficiency, Nuclear Type 21	Leukodystrophy	OMIM:618242
Mitochondrial Complex I Deficiency, Nuclear Type 15	CNS demyelination	OMIM:618237
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination	CNS hypomyelination, Cerebral hypomyelination, Delayed CNS myelination	OMIM:618367
Metachromatic Leukodystrophy Due To Saposin B Deficiency	CNS demyelination, Peripheral demyelination	OMIM:249900
Postnatal Microcephaly-Infantile Hypotonia-Spastic Diplegia-Dysarthria-Intellectual Disability Syndrome	Abnormal CNS myelination	ORPHA:477673
Chromosome 8Q21.11 Deletion Syndrome	CNS hypomyelination	OMIM:614230
Multiple Sclerosis, Susceptibility To	CNS demyelination	OMIM:126200
Leukodystrophy, Hypomyelinating, 17	Leukodystrophy	OMIM:618006
Abetalipoproteinemia	CNS demyelination, Peripheral demyelination	OMIM:200100
Frontal Encephalocele	Leukodystrophy	ORPHA:1931
Hyperphosphatasia-Intellectual Disability Syndrome	Cerebral hypomyelination	ORPHA:247262
3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form	Delayed myelination, Cerebral hypomyelination	ORPHA:79351
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia	CNS hypomyelination	OMIM:619306
Neurodegeneration With Brain Iron Accumulation 7	Leukodystrophy	OMIM:617916
Microcephaly-Intellectual Disability-Sensorineural Hearing Loss-Epilepsy-Abnormal Muscle Tone Syndrome	Cerebral hypomyelination	ORPHA:457351
Neurodevelopmental Disorder With Hypotonia, Craniofacial Abnormalities, And Seizures	CNS hypomyelination	OMIM:614501
Fucosidosis	CNS hypomyelination	OMIM:230000
Leukodystrophy, Hypomyelinating, 16	Leukodystrophy, Delayed CNS myelination	OMIM:617964
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 18	CNS hypomyelination	OMIM:615356
Aicardi-Goutieres Syndrome 6	Leukodystrophy	OMIM:615010
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2	CNS demyelination	OMIM:618193
Pyruvate Carboxylase Deficiency	Delayed myelination, CNS hypomyelination	ORPHA:3008
Allan-Herndon-Dudley Syndrome	Leukodystrophy, Delayed CNS myelination	OMIM:300523
Combined Oxidative Phosphorylation Deficiency 13	Leukodystrophy	OMIM:614932
Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome	Cerebral hypomyelination	ORPHA:496641
Leukodystrophy, Hypomyelinating, 26, With Chondrodysplasia	Leukodystrophy, Delayed CNS myelination	OMIM:620269
Leukodystrophy, Hypomyelinating, 3	Sudanophilic leukodystrophy, Leukodystrophy	OMIM:260600
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1	CNS demyelination	OMIM:221820
Leukodystrophy, Hypomyelinating, 24	Leukodystrophy	OMIM:619851
Mitochondrial Complex I Deficiency, Nuclear Type 4	Leukodystrophy	OMIM:618225
Neurodevelopmental Disorder, Nonprogressive, With Spasticity And Transient Opisthotonus	CNS demyelination, Delayed CNS myelination	OMIM:619653
Mitochondrial Complex Ii Deficiency, Nuclear Type 4	Leukodystrophy	OMIM:619224
Schilder Disease	CNS demyelination	ORPHA:59298
Hengel-Maroofian-Schols Syndrome	Abnormal CNS myelination	OMIM:619641
Aicardi-Goutieres Syndrome 5	Leukodystrophy	OMIM:612952
Waardenburg Syndrome, Type 2E	Cerebral hypomyelination	OMIM:611584
2,4-Dienoyl-Coa Reductase Deficiency	Leukodystrophy, Delayed CNS myelination	OMIM:616034
Waardenburg Syndrome, Type 4A	Leukodystrophy	OMIM:277580
Leukodystrophy, Hypomyelinating, 4	Leukodystrophy	OMIM:612233
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion	CNS hypomyelination	ORPHA:268261
Aicardi-Goutieres Syndrome 4	Leukodystrophy	OMIM:610333
Pyruvate Carboxylase Deficiency	Leukodystrophy	OMIM:266150
Krabbe Disease	CNS demyelination, Peripheral demyelination	OMIM:245200
Dpagt1-Cdg	CNS hypomyelination	ORPHA:86309
Sjogren-Larsson Syndrome	CNS demyelination	OMIM:270200
Multiple Mitochondrial Dysfunctions Syndrome 3	Leukodystrophy	OMIM:615330
Mitochondrial Complex I Deficiency, Nuclear Type 5	Leukodystrophy	OMIM:618226
Childhood-Onset Spasticity With Hyperglycinemia	Leukodystrophy	ORPHA:401866
Trigeminal Neuralgia	CNS demyelination, Peripheral demyelination	ORPHA:221091
Mitochondrial Complex Iv Deficiency, Nuclear Type 10	Abnormal CNS myelination	OMIM:619053
Cerebrooculofacioskeletal Syndrome 1	Delayed myelination, CNS demyelination	OMIM:214150
Peroxisome Biogenesis Disorder 8B	Leukodystrophy, Peripheral demyelination	OMIM:614877
Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant	Symmetric peripheral demyelination, Leukodystrophy	OMIM:169500
Leukodystrophy, Hypomyelinating, 13	Leukodystrophy, Delayed CNS myelination	OMIM:616881
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome	Cerebral hypomyelination	ORPHA:447997
Leigh Syndrome	CNS demyelination	OMIM:256000
Wiedemann-Rautenstrauch Syndrome	CNS hypomyelination, Leukodystrophy	ORPHA:3455
Leukodystrophy, Hypomyelinating, 9	Leukodystrophy	OMIM:616140
Combined Oxidative Phosphorylation Deficiency 4	Leukodystrophy	OMIM:610678
Mitochondrial Complex Iv Deficiency, Nuclear Type 7	Leukodystrophy	OMIM:619051
Late-Infantile/Juvenile Krabbe Disease	Abnormal CNS myelination	ORPHA:206443
Leukodystrophy, Progressive, Early Childhood-Onset	Leukodystrophy	OMIM:617762
Orofaciodigital Syndrome Xiv	CNS hypomyelination	OMIM:615948
Canavan Disease	CNS demyelination	OMIM:271900
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia	Leukodystrophy	OMIM:614299
Marchiafava-Bignami Disease	CNS demyelination	ORPHA:221074
Intellectual Disability-Seizures-Abnormal Gait-Facial Dysmorphism Syndrome	Cerebral hypomyelination	ORPHA:513456
Adult Krabbe Disease	CNS demyelination, Peripheral demyelination	ORPHA:206448
Rere-Related Neurodevelopmental Syndrome	CNS demyelination	ORPHA:494344
Hyperglycinemia, Lactic Acidosis, And Seizures	Leukodystrophy	OMIM:614462
Biliary, Renal, Neurologic, And Skeletal Syndrome	CNS hypomyelination	OMIM:619534
Isolated Sedoheptulokinase Deficiency	Abnormal CNS myelination	ORPHA:440713
Combined Oxidative Phosphorylation Defect Type 23	Leukodystrophy	ORPHA:444013
Progressive Encephalopathy With Leukodystrophy Due To Decr Deficiency	Leukodystrophy	ORPHA:431361
Alg8-Cdg	Leukodystrophy	ORPHA:79325
Multiple Sulfatase Deficiency	CNS demyelination, Peripheral demyelination	OMIM:272200
Peroxisome Biogenesis Disorder 12A (Zellweger)	CNS demyelination	OMIM:614886
Peroxisome Biogenesis Disorder 6B	Leukodystrophy	OMIM:614871
Combined Oxidative Phosphorylation Deficiency 59	CNS demyelination	OMIM:620646
Immunodeficiency 23	Abnormal CNS myelination	OMIM:615816
Mitochondrial Dna Depletion Syndrome 13 (Encephalomyopathic Type)	Leukodystrophy, Delayed CNS myelination	OMIM:615471
Progressive Multifocal Leukoencephalopathy	CNS demyelination	ORPHA:217260
Muscle-Eye-Brain Disease With Bilateral Multicystic Leucodystrophy	Leukodystrophy	ORPHA:370997
Xeroderma Pigmentosum, Complementation Group B	Abnormal CNS myelination	OMIM:610651
Hurler Syndrome	Abnormal CNS myelination	OMIM:607014
Aicardi-Goutieres Syndrome 1	CNS demyelination	OMIM:225750
X-Linked Cerebral Adrenoleukodystrophy	CNS demyelination, Diffuse demyelination of the cerebral white matter	ORPHA:139396
Secondary Syringomyelia	CNS demyelination	ORPHA:99857
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 9	Leukodystrophy	OMIM:616538
Neurodevelopmental Disorder With Intracranial Hemorrhage, Seizures, And Spasticity	Abnormal CNS myelination, Abnormal myelination	OMIM:620371
Metachromatic Leukodystrophy, Late Infantile Form	Leukodystrophy	ORPHA:309256
Acute Disseminated Encephalomyelitis	CNS demyelination	ORPHA:83597
Metachromatic Leukodystrophy, Juvenile Form	Leukodystrophy	ORPHA:309263
Combined Oxidative Phosphorylation Deficiency 58	CNS demyelination	OMIM:620451
Hemophagocytic Lymphohistiocytosis, Familial, 2	CNS demyelination	OMIM:603553
Glycogen Storage Disease Ii	Abnormal CNS myelination	OMIM:232300
Leigh Syndrome	Leukodystrophy	ORPHA:506
Peroxisome Biogenesis Disorder 1B	Leukodystrophy	OMIM:601539
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome	Leukodystrophy	ORPHA:79124
Metachromatic Leukodystrophy, Adult Form	Leukodystrophy	ORPHA:309271
Isolated Complex I Deficiency	Leukodystrophy	ORPHA:2609
Cerebroretinal Microangiopathy With Calcifications And Cysts 1	Leukodystrophy	OMIM:612199
Niemann-Pick Disease Type C	Demyelinating peripheral neuropathy, Abnormal CNS myelination, Leukodystrophy	ORPHA:646
Rabson-Mendenhall Syndrome	CNS demyelination	ORPHA:769
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities	CNS demyelination	OMIM:620024
De Sanctis-Cacchione Syndrome	Leukodystrophy	OMIM:278800
Developmental Delay With Or Without Intellectual Impairment Or Behavioral Abnormalities	Leukodystrophy	OMIM:619575
Developmental Delay, Impaired Speech, And Behavioral Abnormalities	Delayed myelination, Leukodystrophy, Peripheral demyelination	OMIM:619475
Bickerstaff Brainstem Encephalitis	CNS demyelination, Acute demyelinating polyneuropathy	ORPHA:79138
Cerebrotendinous Xanthomatosis	CNS demyelination, Hypermyelinated retinal nerve fibers	ORPHA:909
Mitochondrial Complex I Deficiency, Nuclear Type 1	Leukodystrophy	OMIM:252010
Aicardi-Goutières Syndrome	Demyelinating peripheral neuropathy, Leukodystrophy	ORPHA:51
Acute Transverse Myelitis	CNS demyelination	ORPHA:139417
Mitochondrial Complex Iv Deficiency, Nuclear Type 5	CNS demyelination, Peripheral demyelination	OMIM:220111

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cyth1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cyth1.

No publications found that use IMPC mice or data for Cyth1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Cyth1^{tm1a(EUCOMM)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Cyth1^{tm33724(L1L2_gt1)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter

My Genes

About the IMPC

Data

Human Diseases

Publications

News

Blog

Help

IMPC Cloud

Contact us