Gene: Tbc1d22a

Order

Name TBC1 domain family, member 22a

Synonyms D15Ertd781e

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1289265    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Tbc1d22a

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Tbc1d22a data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased circulating amylase level Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 7.2E-17
increased red blood cell distribution width Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 2.63E-8
thrombocytopenia Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 3.98E-8
increased circulating alanine transaminase level Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 1.15E-6
increased circulating free fatty acid level Tbc1d22atm1b(KOMP)Wtsi HOM Female postnatal 1.51E-6
increased circulating alkaline phosphatase level Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 2.25E-6
decreased circulating triglyceride level Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 4.06E-6
increased circulating aspartate transaminase level Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 1.54E-5
decreased circulating fructosamine level Tbc1d22atm1b(KOMP)Wtsi HOM Female Male postnatal 4.27E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse nervous system reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (3)
  • Tbc1d22atm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    pituitary gland, HET, Female, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
trunk (2)
  • Tbc1d22atm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
nervous system (1)
  • Tbc1d22atm1b(KOMP)Wtsi
    pituitary gland, HET, Female, WTSI
reproductive system (1)
  • Tbc1d22atm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
urinary system (1)
  • Tbc1d22atm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    42 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (70)
  • Tbc1d22atm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Tbc1d22atm1b(KOMP)Wtsi
    HOM, Male, WTSI

show all 70 images

Eye Morphology (1)
  • Tbc1d22atm1b(KOMP)Wtsi
    fused cornea and lens, HOM, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Tbc1d22atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Tbc1d22atm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene