Gene: Itch

Order

Name itchy, E3 ubiquitin protein ligase

Synonyms
  • 6720481N21Rik
  • 8030492O04Rik
  • C230047C07Rik
  • AIP4

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1202301    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Itch

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Itch data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased bone mineral content Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.25E-43
decreased bone mineral density Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.0E-33
decreased circulating alkaline phosphatase level Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.13E-26
abnormal bone structure Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.14E-25
increased neutrophil cell number Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.05E-24
tremors Itchtm1b(EUCOMM)Hmgu HOM Female postnatal 1.78E-9
decreased circulating fructosamine level Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.09E-9
increased mean corpuscular volume Itchtm1(NCOM)Cmhd HET Female postnatal 7.59E-8
increased heart weight Itchtm1b(EUCOMM)Hmgu HOM Female postnatal 7.75E-8
increased red blood cell distribution width Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.13E-6
increased circulating calcium level Itchtm1b(EUCOMM)Hmgu HOM Female postnatal 1.98E-6
abnormal tooth morphology Itchtm1b(EUCOMM)Hmgu HOM Male postnatal 4.93E-6
decreased total body fat amount Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.23E-5
increased circulating total protein level Itchtm1b(EUCOMM)Hmgu HOM Female postnatal 2.3E-5
decreased grip strength Itchtm1b(EUCOMM)Hmgu HOM Female postnatal 2.35E-5
increased eosinophil cell number Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.79E-5
increased large unstained cell number Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 6.14E-5
decreased lymphocyte cell number Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 7.58E-5
decreased mean corpuscular volume Itchtm1b(EUCOMM)Hmgu HOM Female postnatal 7.6E-5
abnormal head size Itchtm1b(EUCOMM)Hmgu HOM Male postnatal 8.16E-5
absent startle reflex Itchtm1b(EUCOMM)Hmgu HOM Male postnatal 8.17E-5
increased lean body mass Itchtm1b(EUCOMM)Hmgu HOM Female Male postnatal 8.63E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Esophagus 2 No (7/415)
Eye 2 No (2/2)
Gall bladder 2 No (1/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No (2/2)
Oral epithelium 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (1/2)
Trachea 2 No
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    cardiovascular system
    nervous system
    sensory organ
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/485) (2/2)
Ear 1 (1/485)
Embryo 1 (1/485) (2/2)
Eye 1 (1/485) (2/2)
Foot 1 (1/485) (2/2)
Forebrain 1 (1/485) (2/2)
Forelimb 1 (1/485) (2/2)
Hand 1 (1/485) (2/2)
Head 1 (5/485) (2/2)
Heart 1 (1/485)
Hindbrain 1 (6/485) (2/2)
Hindlimb 1 (1/485) (2/2)
Liver 1 (1/485)
Lung 1 (1/485)
Mandibular process 1 (1/485)
Maxillary process 1 (1/485)
Midbrain 1 (1/485) (2/2)
Oral cavity 1 (1/485)
Skin 1 (1/485)
Tail 1 (1/485) (2/2)
Tail somite 1 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    12 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    12 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Adult LacZ: LacZ Images Wholemount
    19 Images
  • X-ray: XRay Images Lateral Orientation
    12 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Itchtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Itchtm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Itchtm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette)
Vector
Gene