Gene: Rasa3

Name RAS p21 protein activator 3

Synonyms
  • Ras GTPase-activating protein III
  • scat
  • R-Ras gap
  • GAPIII activator 3
  • hlb381
  • GAPIII

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1197013   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Rasa3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Rasa3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal forebrain morphology Rasa3tm1b(KOMP)Mbp HOM Female embryonic day 12.5 0.0
abnormal midbrain morphology Rasa3tm1b(KOMP)Mbp HOM Female embryonic day 12.5 0.0
hemorrhage Rasa3tm1b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Rasa3tm1b(KOMP)Mbp HOM Female Male n/a 0.0
decreased circulating glucose level Rasa3tm1b(KOMP)Mbp HET Female Male postnatal 8.35E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Bone marrow 2 No (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Epididymis 2 No (4/106) (1/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Submandibular gland 2 No (1/104) (2/2)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/440) (1/2)
Ear 1 (1/440) (1/2)
Embryo 1 (1/440) (1/2)
Eye 1 (1/440) (1/2)
Foot 1 (1/2)
Forebrain 1 (1/440) (1/2)
Forelimb 1 (1/440) (1/2)
Hand 1 (1/2)
Head 1 (5/440) (1/2)
Heart 1 (1/440) (1/2)
Hindbrain 1 (5/440) (1/2)
Hindlimb 1 (1/440) (1/2)
Liver 1 (1/440) (1/2)
Lung 1 (1/440) Image Only
Mandibular process 1 (1/440) (1/2)
Maxillary process 1 (1/440) (1/2)
Midbrain 1 (1/440) (1/2)
Oral cavity 1 (1/440) (1/2)
Skin 1 (1/440) (1/2)
Tail 1 (1/440) (1/2)
Tail somite 1 (1/440) (1/2)


Associated Images

Associated Images
  • Gross Morphology Embryo E12.5
    8 Images
  • Sleep Wake: Wake state (bmp file)
    13 Images
  • Embryo LacZ: LacZ images wholemount
    16 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • Combined SHIRPA and Dysmorphology
    3 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Rasa3tm1a(KOMP)J KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Rasa3tm1b(KOMP)J Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Rasa3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Rasa3tm47947(L1L2_Bact_P)
Vector
Gene