Gene: Man2b2

Name mannosidase 2, alpha B2

Synonyms 135 kDa alpha-D-mannosidase

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1195262   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Man2b2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Man2b2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
enlarged lymph nodes Man2b2tm1b(KOMP)Wtsi HOM Male postnatal 0.0
small adrenal glands Man2b2tm1b(KOMP)Wtsi HOM Male postnatal 0.0
small superior vagus ganglion Man2b2tm1b(KOMP)Wtsi HOM Female postnatal 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/176) (2/2)
Aorta 2 No (2/530) (2/2)
Blood vessel 2 No
Bone 2 No (1/515)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530) (2/2)
Cerebellum 2 No (6/530) (2/2)
Cerebral cortex 2 No (6/530)
Eye 2 No (1/530)
Gall bladder 2 No
Heart 2 No (4/530) (2/2)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530)
Liver 2 No
Lower urinary tract 2 No (3/530) (2/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530)
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No (2/176) (2/2)
Ovary 2 No (1/530) (1/2)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530) (1/2)
Parathyroid gland 2 No (2/516) (2/2)
Peripheral nervous system 2 No (4/530) (2/2)
Peyer's patch 2 No (1/176)
Pituitary gland 2 No (2/530) (2/2)
Prostate gland 2 No (3/530)
Skeletal muscle tissue 2 No
Skin 2 No (2/530)
Small intestine 2 No (5/530) (2/2)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530) (1/2)
Trachea 2 No (5/530) (2/2)
Uterus 2 No (1/530)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system digestive system cardiovascular system nervous system set of connective tissues reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (13)
  • Man2b2tm1b(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    CARTILAGE TISSUE, RIB, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    SPLEEN, HET, Male, WTSI

show all 13 images

nervous system (3)
  • Man2b2tm1b(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    PITUITARY GLAND, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    STRIATUM, HET, Female, WTSI
digestive system (2)
  • Man2b2tm1b(KOMP)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    ESOPHAGUS, HET, Female, WTSI
endocrine system (2)
  • Man2b2tm1b(KOMP)Wtsi
    PARATHYROID GLAND, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
reproductive system (2)
  • Man2b2tm1b(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    OVARY, HET, Female, WTSI
urinary system (2)
  • Man2b2tm1b(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
cardiovascular system (1)
  • Man2b2tm1b(KOMP)Wtsi
    AORTA, HET, Female, WTSI
immune system (1)
  • Man2b2tm1b(KOMP)Wtsi
    SPLEEN, HET, Male, WTSI
musculoskeletal system (1)
  • Man2b2tm1b(KOMP)Wtsi
    CARTILAGE TISSUE, RIB, HET, Female, WTSI
respiratory system (1)
  • Man2b2tm1b(KOMP)Wtsi
    LUNG, HET, Female, WTSI
set of connective tissues (1)
  • Man2b2tm1b(KOMP)Wtsi
    CARTILAGE TISSUE, RIB, HET, Female, WTSI

Associated Images

Associated Images
  • Eye Morphology: Images Slit Lamp
    2 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Dorso Ventral
    59 Images
  • X-ray: XRay Images Lateral Orientation
    58 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    15 Images
  • Eye Morphology: Images Ophthalmoscopy
    1 Images
  • Gross Pathology and Tissue Collection
    12 Images
  • X-ray: XRay Images Hind Leg and Hip
    16 Images
  • Combined SHIRPA and Dysmorphology
    2 Images
Legacy Phenotype Associated Images
Xray (70)
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Male, WTSI

show all 70 images

Eye Morphology (3)
  • Man2b2tm1b(KOMP)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    eyelids fail to open, HOM, Female, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    Fused cornea and lens, HOM, Female, WTSI
Histology Slide (3)
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Unsexed, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    HOM, Unsexed, WTSI
  • Man2b2tm1b(KOMP)Wtsi
    HET, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Man2b2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Man2b2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene