Gene: Cyp27b1

Order

Name cytochrome P450, family 27, subfamily b, polypeptide 1

Synonyms
  • Pddr
  • Cyp40
  • Cp2b
  • Cyp1
  • 25-hydroxyvitamin D3 1alpha-hydroxylase
  • Vdd1
  • P450VD1alpha
  • 1alpha(OH)ase
  • Vddr
  • 25(OH)D 1alpha-hydroxylase
  • Cyp27b
  • P450c1
  • VddrI

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:1098274    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Cyp27b1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cyp27b1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased bone mineral density Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 0.0
short tibia Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased bone mineral content Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.68E-44
abnormal bone structure Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.44E-43
decreased body length Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 6.33E-43
decreased lean body mass Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.57E-24
decreased circulating calcium level Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.71E-14
hypoactivity Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.77E-13
abnormal behavior Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 6.06E-13
abnormal clavicle morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal femur morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal fibula morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal humerus morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal joint morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal radius morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal rib morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal scapula morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal tibia morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal ulna morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.26E-13
abnormal vertebrae morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.24E-12
abnormal cranium morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 7.41E-12
increased circulating alkaline phosphatase level Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.29E-11
decreased total body fat amount Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.6E-11
decreased circulating phosphate level Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.0E-11
decreased grip strength Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.76E-9
decreased circulating HDL cholesterol level Cyp27b1tm1b(EUCOMM)Hmgu HOM Male postnatal 1.26E-8
increased circulating bilirubin level Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.84E-8
abnormal pelvic girdle bone morphology Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.83E-8
decreased circulating cholesterol level Cyp27b1tm1b(EUCOMM)Hmgu HOM Male postnatal 3.03E-8
decreased circulating glucose level Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.01E-7
decreased vertical activity Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.53E-7
decreased startle reflex Cyp27b1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.74E-6

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • X-ray: XRay Images Dorso Ventral
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • Gross Pathology and Tissue Collection
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cyp27b1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Cyp27b1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Cyp27b1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene