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Gene: Dpf2 MGI:109529

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Gene Summary

Name:
double PHD fingers 2
Synonyms:
ubi-d4,  Req,  2210010M07Rik,  requiem,  Baf45d

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal heart morphology Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
abnormal embryo size Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
pallor Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
abnormal kidney morphology Dpf2tm1b(EUCOMM)Hmgu HET Early adult 0.00
abnormal craniofacial morphology Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
abnormal tail morphology Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
abnormal limb morphology Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
edema Dpf2tm1b(EUCOMM)Hmgu HOM E15.5 0.00
abnormal seminal vesicle morphology Dpf2tm1b(EUCOMM)Hmgu HET Early adult 0.00
preweaning lethality, complete penetrance Dpf2tm1b(EUCOMM)Hmgu HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

No Adult expression data was found for this gene.

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
N/A Ambiguous
Axial skeleton N/A homozygote 0.0% (0 of 2)
Brain N/A heterozygote Ambiguous
Brain N/A homozygote 0.0% (0 of 2)
N/A Ambiguous
Central nervous system ganglion N/A homozygote 0.0% (0 of 2)
Ear N/A heterozygote Ambiguous
Ear N/A homozygote 0.0% (0 of 2)
Embryo N/A heterozygote 0.0% (0 of 3)
Embryo N/A homozygote 100% (2 of 2)
Eye N/A heterozygote Ambiguous
Eye N/A homozygote 100% (2 of 2)
Footplate N/A heterozygote Ambiguous
Footplate N/A homozygote 0.0% (0 of 2)
Forebrain N/A heterozygote Ambiguous
Forebrain N/A homozygote 0.0% (0 of 2)
Forelimb N/A heterozygote Ambiguous
Forelimb N/A homozygote 0.0% (0 of 2)
N/A Ambiguous
Gut N/A homozygote 100% (2 of 2)
Handplate N/A heterozygote Ambiguous
Handplate N/A homozygote 0.0% (0 of 2)
Head N/A heterozygote Ambiguous
Head N/A homozygote 0.0% (0 of 2)
Heart N/A heterozygote Ambiguous
Heart N/A homozygote 100% (2 of 2)
Hindbrain N/A heterozygote Ambiguous
Hindbrain N/A homozygote 0.0% (0 of 2)
Hindlimb N/A heterozygote Ambiguous
Hindlimb N/A homozygote 0.0% (0 of 2)
Liver N/A heterozygote Ambiguous
Liver N/A homozygote 100% (2 of 2)
Lung N/A heterozygote Ambiguous
Lung N/A homozygote 0.0% (0 of 2)
Mandibular process N/A heterozygote Ambiguous
Mandibular process N/A homozygote 0.0% (0 of 2)
Maxillary process N/A heterozygote Ambiguous
Maxillary process N/A homozygote 0.0% (0 of 2)
Midbrain N/A heterozygote Ambiguous
Midbrain N/A homozygote 0.0% (0 of 2)
N/A Ambiguous
Nose N/A homozygote 0.0% (0 of 2)
Oral cavity N/A heterozygote Ambiguous
Oral cavity N/A homozygote 0.0% (0 of 2)
N/A Ambiguous
Chorioallantoic placenta N/A homozygote 100% (2 of 2)
N/A Ambiguous
Skeleton N/A homozygote 0.0% (0 of 2)
Skin N/A heterozygote Ambiguous
Skin N/A homozygote 100% (2 of 2)
N/A Ambiguous
Spinal cord N/A homozygote 0.0% (0 of 2)
Tail somite N/A heterozygote Ambiguous
Tail somite N/A homozygote 100% (2 of 2)
Tail N/A heterozygote Ambiguous
Tail N/A homozygote 0.0% (0 of 2)
N/A Ambiguous
Trachea N/A homozygote 0.0% (0 of 2)
N/A Ambiguous
Urinary system N/A homozygote 0.0% (0 of 2)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
axial skeleton Ambiguous
brain 0.0%
central nervous system ganglion Ambiguous
ear 0.0%
embryo 0.0%
eye 0.0%
footplate 0.0%
forebrain 0.0%
forelimb 0.0%
gut Ambiguous
handplate 0.0%
head 0.0%
heart 0.0%
hindbrain 0.0%
hindlimb 0.0%
liver 0.0%
lung 0.0%
mandibular process 0.0%
maxillary process 0.0%
midbrain 0.0%
nose Ambiguous
oral cavity 0.0%
placenta Ambiguous
skeleton Ambiguous
skin 0.0%
spinal cord Ambiguous
tail 0.0%
tail somite group 0.0%
trachea Ambiguous
urinary system Ambiguous

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Gross Pathology and Tissue Collection

Images

9 Images

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Embryo LacZ

LacZ images wholemount

20 Images

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Immunophenotyping

Panel A FCS file(s)

6 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Gross Morphology Embryo E14.5-E15.5

Images

8 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Histopathology

Images

2 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Eye Morphology

Images Ophthalmoscopy

2 Images

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Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Dpf2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dpf2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Coffin-Siris Syndrome 7
Brachydactyly, Ventricular septal defect, Bicuspid aortic valve, Polyhydramnios, Clinodactyly of ... OMIM:618027
Coffin-Siris Syndrome
Ventricular septal defect, Abnormal heart morphology, Short 5th finger, Atrial septal defect, Int... ORPHA:1465

The table below shows human diseases predicted to be associated to Dpf2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Congenital Heart Block
Pericardial effusion, Hydrops fetalis, Peripheral edema, Pallor, Endocardial fibroelastosis, Intr... ORPHA:60041
Hb Bart'S Hydrops Fetalis
Pericarditis, Polyhydramnios, Hydrops fetalis, Pallor, Oligohydramnios ORPHA:163596
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Peripheral Cone Dystrophy
Pallor OMIM:609021
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Optic Atrophy 7 With Or Without Auditory Neuropathy
Hypertrophic cardiomyopathy, Pallor OMIM:612989
Dermatitis, Atopic
Dry skin, Pallor, Facial erythema OMIM:603165
Optic Atrophy 1
Pallor OMIM:165500
Breath-Holding Spells
Pallor OMIM:607578
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Acral Self-Healing Collodion Baby
Edema of the dorsum of feet, Edema of the dorsum of hands, Erythema, Lack of skin elasticity, Pal... ORPHA:281127
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor ORPHA:2786
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Hypertrophic cardiomyopathy, Pallor OMIM:613561
Thiamine-Responsive Megaloblastic Anemia Syndrome
Atrial septal defect, Ventricular septal defect, Pallor ORPHA:49827
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
American Trypanosomiasis
Edema, Periorbital edema, Myocarditis, Cardiomyopathy, Pallor ORPHA:3386
Hemoglobin D Disease
Pallor ORPHA:90039
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Cyclic Vomiting Syndrome
Cardiomyopathy, Pallor OMIM:500007
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Rheumatic Fever
Pericarditis, Abnormal heart valve morphology, Myocarditis, Erythema, Endocarditis, Abnormal aort... ORPHA:3099
Retinitis Pigmentosa 51
Polydactyly, Pallor OMIM:613464
Hyperinsulinism Due To Ucp2 Deficiency
Hypertrophic cardiomyopathy, Pallor ORPHA:276556
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor ORPHA:276608
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypertrophic cardiomyopathy, Pallor ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hypertrophic cardiomyopathy, Pallor ORPHA:276580
Fanconi Anemia, Complementation Group I
Ventricular septal defect, Absent thumb, Short thumb, Short 1st metacarpal, Hypoplasia of the rad... OMIM:609053
Kcnq2-Related Epileptic Encephalopathy
Pallor, Cerebral edema, Facial erythema ORPHA:439218
Beta-Thalassemia
Hypertrophic cardiomyopathy, Pallor, Skin ulcer ORPHA:848
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Lymphatic Malformation 7
Nonimmune hydrops fetalis, Edema, Lymphedema, Pericardial effusion, Facial edema, Increased nucha... OMIM:617300
Anemia, Congenital Dyserythropoietic, Type Ib
Syndactyly, Pallor OMIM:615631
Myopathic Ehlers-Danlos Syndrome
Tapered finger, Talipes equinovarus, Pallor, Congenital finger flexion contractures, Adducted thumb ORPHA:536516
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor, Nonimmune hydrops fetalis OMIM:266200
Deafness-Lymphedema-Leukemia Syndrome
Pallor, Lymphedema ORPHA:3226
Evans Syndrome
Pallor, Petechiae ORPHA:1959
Hyperinsulinism Due To Hnf1A Deficiency
Pallor ORPHA:324575
Myelofibrosis
Pallor, Purpura OMIM:254450
Dravet Syndrome
Pallor, Tibial torsion ORPHA:33069
Irida Syndrome
Pallor ORPHA:209981
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Primary Myelofibrosis
Ecchymosis, Pallor, Petechiae, Purpura ORPHA:824
Idiopathic Pulmonary Hemosiderosis
Pallor, Cardiomegaly ORPHA:99931
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Pallor OMIM:611590
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Cold Agglutinin Disease
Pallor ORPHA:56425
Retinitis Pigmentosa 75
Pallor OMIM:617023
Waldenström Macroglobulinemia
Periorbital edema, Pedal edema, Pallor, Pleural effusion, Purpura ORPHA:33226
Beta-Ketothiolase Deficiency
Pallor, Edema, Dehydration ORPHA:134
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Pallor OMIM:600462
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Anemia, Hypochromic Microcytic, With Iron Overload 2
Pallor OMIM:615234
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Anemic pallor, Edema ORPHA:329971
Senior-Loken Syndrome 8
Polydactyly, Pallor OMIM:616307
3-Hydroxy-3-Methylglutaric Aciduria
Dilated cardiomyopathy, Pallor, Edema, Dehydration ORPHA:20
Elliptocytosis 1
Pallor OMIM:611804
Sepsis In Premature Infants
Petechiae, Pallor, Edema, Purpura ORPHA:90051
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Tay-Sachs Disease
Pallor OMIM:272800
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Pallor ORPHA:263455
Hereditary Spherocytosis
Restrictive cardiomyopathy, Pallor, Skin ulcer ORPHA:822
Fumarase Deficiency
Ascites, Perimembranous ventricular septal defect, Pallor, Polyhydramnios OMIM:606812
Dominant Beta-Thalassemia
Bowing of the long bones, Dilated cardiomyopathy, Skin ulcer, Genu valgum, Pallor ORPHA:231226
Refractory Anemia With Excess Blasts
Anemic pallor, Pedal edema ORPHA:86839
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Letterer-Siwe Disease
Pallor OMIM:246400
Beta-Thalassemia Major
Bowing of the long bones, Dilated cardiomyopathy, Skin ulcer, Genu valgum, Pallor ORPHA:231214
Congenital Dyserythropoietic Anemia Type Iii
Pallor ORPHA:98870
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Myopathy, Mitochondrial, And Ataxia
Pallor OMIM:617675
Idiopathic Hypereosinophilic Syndrome
Swelling of proximal interphalangeal joints, Angioedema, Dilated cardiomyopathy, Clubbing, Myocar... ORPHA:3260
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Alternating Hemiplegia Of Childhood
Cardiomyopathy, Pallor, Dehydration ORPHA:2131
Fanconi Anemia, Complementation Group E
Anemic pallor, Absent thumb, Absent radius, Short thumb, Abnormal heart morphology, Complete dupl... OMIM:600901
Diamond-Blackfan Anemia
Ventricular septal defect, Nonimmune hydrops fetalis, Absent thumb, Short thumb, Partial duplicat... ORPHA:124
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Pearson Marrow-Pancreas Syndrome
Pallor, Erythema, Hydrops fetalis, Dehydration OMIM:557000
Histiocytoid Cardiomyopathy
Pulmonary edema, Ventricular septal defect, Pallor, Cardiomegaly ORPHA:137675
Diamond-Blackfan Anemia 1
Ventricular septal defect, Tricuspid stenosis, Absent thumb, Short thumb, Partial duplication of ... OMIM:105650
Esophageal Atresia
Ventricular septal defect, Polyhydramnios, Pallor, Clinodactyly, Tetralogy of Fallot ORPHA:1199
Fanconi Anemia, Complementation Group A
Anemic pallor, Absent thumb, Absent radius, Short thumb, Abnormal heart morphology, Complete dupl... OMIM:227650
Infection-Related Hemolytic Uremic Syndrome
Edema, Myocarditis, Pleural empyema, Pallor, Generalized edema ORPHA:544482
Fanconi Anemia, Complementation Group C
Ventricular septal defect, Anemic pallor, Absent thumb, Absent radius, Short thumb, Intrauterine ... OMIM:227645
Cardiac Valvular Dysplasia 1
Ventricular septal defect, Left atrial enlargement, Tricuspid stenosis, Edema, Valvular pulmonary... OMIM:212093
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Pallor ORPHA:300298
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Degcags Syndrome
Syndactyly, Toe syndactyly, Ventricular septal defect, Polyhydramnios, Short thumb, Preaxial hand... OMIM:619488
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Aregenerative Anemia
Pallor ORPHA:101096
Adenohypophysitis
Pallor ORPHA:95512
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Panhypophysitis
Pallor ORPHA:95513
Retinitis Pigmentosa And Erythrocytic Microcytosis
Pallor OMIM:616959
Sheehan Syndrome
Dry skin, Pallor ORPHA:91355
Pituitary Apoplexy
Pallor ORPHA:95613
Von Hippel-Lindau Disease
Myocarditis, Cardiomyopathy, Pallor, Macular edema ORPHA:892
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor ORPHA:98849
Prolactinoma
Pallor ORPHA:2965
Fanconi Anemia, Complementation Group D2
Anemic pallor, Absent thumb, Absent radius, Short thumb, Preaxial hand polydactyly, Partial dupli... OMIM:227646
Congenital Total Pulmonary Venous Return Anomaly
Atrial situs ambiguous, Ventricular septal defect, Dextrocardia, Mitral atresia, Cardiomegaly, Su... ORPHA:99125
Incontinentia Pigmenti
Erythema, Pallor OMIM:308300
Autosomal Recessive Malignant Osteopetrosis
Pallor, Abnormal metaphysis morphology, Abnormal pulmonary valve morphology, Bowing of the long b... ORPHA:667
Tsh-Secreting Pituitary Adenoma
Pericardial effusion, Pallor ORPHA:91347
Multiple Endocrine Neoplasia Type 2
Pallor ORPHA:653
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor OMIM:233450
Coffin-Siris Syndrome 7
Brachydactyly, Ventricular septal defect, Bicuspid aortic valve, Polyhydramnios, Clinodactyly of ... OMIM:618027
Coffin-Siris Syndrome
Ventricular septal defect, Abnormal heart morphology, Short 5th finger, Atrial septal defect, Int... ORPHA:1465

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dpf2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dpf2.

No publications found that use IMPC mice or data for Dpf2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Dpf2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Dpf2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Dpf2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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