Gene: Nxn

Order

Name nucleoredoxin

Synonyms l11Jus13

Status ES CellsMice
tm1a
Mice
em1
Mice
em1
Mice
tm1b
Mice
em1
phenotype data available

Links MGI:109331    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal     Homozygous - Subviable

Phenotype associations for Nxn

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nxn data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal craniofacial morphology Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal embryo size Nxnem1(IMPC)Bay HOM Female Male embryonic day 18.5 0.0
abnormal embryo size Nxnem1(IMPC)J HOM Female Male embryonic day 18.5 0.0
abnormal facial morphology Nxnem1(IMPC)Bay HOM Female Male embryonic day 18.5 0.0
abnormal facial morphology Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal facial morphology Nxnem1(IMPC)J HOM Female Male embryonic day 18.5 0.0
abnormal head shape Nxnem1(IMPC)Bay HOM Female Male embryonic day 18.5 0.0
abnormal head shape Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal head size Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal head size Nxnem1(IMPC)Bay HOM Female Male embryonic day 18.5 0.0
anophthalmia Nxntm1a(EUCOMM)Wtsi HET Female postnatal 0.0
cleft palate Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 15.5 0.0
cleft palate Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
cleft palate Nxnem1(IMPC)J HOM Female Male embryonic day 18.5 0.0
facial cleft Nxnem1(IMPC)Bay HOM Female Male embryonic day 18.5 0.0
facial cleft Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
facial cleft Nxnem1(IMPC)J HOM Male embryonic day 18.5 0.0
preweaning lethality, complete penetrance Nxnem1(IMPC)Bay HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Nxnem1(IMPC)J HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Nxntm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Nxnem1(IMPC)Mbp HOM Female Male n/a 0.0
preweaning lethality, incomplete penetrance Nxntm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
small adrenal glands Nxntm1b(EUCOMM)Wtsi HET Male postnatal 0.0
decreased lean body mass Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 1.72E-7
short tibia Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 7.57E-7
abnormal digit morphology Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 7.98E-7
abnormal snout morphology Nxntm1b(EUCOMM)Wtsi HET Female postnatal 6.65E-6
increased grip strength Nxntm1a(EUCOMM)Wtsi HET Female Male postnatal 1.13E-5
abnormal bone structure Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 1.88E-5
abnormal retinal blood vessel morphology Nxnem1(IMPC)Bay HET Male postnatal 1.9E-5
abnormal eyelid morphology Nxntm1b(EUCOMM)Wtsi HET Female postnatal 1.94E-5
decreased body length Nxnem1(IMPC)J HET Female Male postnatal 2.2E-5
abnormal cranium morphology Nxntm1b(EUCOMM)Wtsi HET Female postnatal 2.38E-5
decreased bone mineral content Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 3.84E-5
decreased cardiac muscle contractility Nxntm1a(EUCOMM)Wtsi HET Female postnatal 3.87E-5
decreased body length Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 4.54E-5
prolonged PQ interval Nxnem1(IMPC)J HET Female postnatal 4.79E-5
increased or absent threshold for auditory brainstem response Nxntm1b(EUCOMM)Wtsi HET Female postnatal 5.09E-5
abnormal bone structure Nxnem1(IMPC)J HET Male postnatal 5.25E-5
decreased lean body mass Nxnem1(IMPC)Bay HET Female Male postnatal 8.18E-5
decreased bone mineral content Nxnem1(IMPC)J HET Male postnatal 9.99E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Adrenal gland 14 No (2/415) (11/14)
Aorta 16 No (13/16)
Blood 2 No
Blood vessel 2 No (2/2)
Bone 12 No (2/12)
Bone marrow 2 No
Brain 16 No (16/16)
Brainstem 16 No (10/16)
Brown adipose tissue 2 No
Brown adipose tissue 12 No
Cartilage tissue 16 No (10/16)
Cecum 8 No (12/383) (6/8)
Cerebellum 16 No (9/16)
Cerebral cortex 16 No (8/16)
Chest bone 6 No (4/6)
Colon 6 No (12/127) (4/6)
Cranium 6 No
Diaphragm 6 No (4/6)
Duodenum 4 No (2/127) (4/4)
Epididymis 8 No (18/134) (1/8)
Esophagus 14 No (7/415) (12/14)
Eye 16 No (12/16)
Gall bladder 12 No (10/12)
Gonadal fat pad 4 No
Harderian gland 6 No (4/6)
Heart 16 No (6/16)
Hindlimb 6 No (4/6)
Hippocampus 16 No (8/16)
Hypothalamus 16 No (8/16)
Ileum 4 No (14/127) (4/4)
Jejunum 4 No (6/127) (4/4)
Kidney 16 No (18/584) (16/16)
Large intestine 16 No (10/584) (14/16)
Liver 16 No (2/16)
Lower urinary tract 16 No (11/16)
Lung 16 No (15/16)
Lymph node 16 No (6/16)
Main olfactory bulb 6 No (4/6)
Mammary gland 16 No (7/16)
Mesenteric lymph node 8 No (2/8)
Mesenteric adipose tissue 4 No (4/4)
Midbrain 6 No (6/6)
Esophagus 2 No (2/2)
Olfactory lobe 14 No (8/14)
Olfactory lobe 2 No (2/2)
Oral epithelium 10 No (4/10)
Ovary 16 No (1/584) (7/16)
Oviduct 16 No (7/16)
Pancreas 16 No (5/584) (1/16)
Parathyroid gland 12 No (2/12)
Parotid gland 6 No (4/6)
Penis 6 No (2/6)
Peripheral nervous system 16 No (13/16)
Peyer's patch 2 No (2/2)
Peyer's patch 14 No (4/14)
Pituitary gland 16 No (12/16)
Prostate gland 16 No (12/584) (6/16)
Quadriceps 4 No (4/4)
Sciatic nerve 6 No (4/6)
Skeletal muscle 14 No (12/14)
Skeletal muscle tissue 2 No (2/2)
Skin 16 No (14/16)
Small intestine 16 No (9/584) (14/16)
Spinal cord 16 No (14/16)
Spleen 16 No (2/584) (6/16)
Stomach 16 No (12/584) (15/16)
Stomach pyloric region 6 No
Striatum 16 No (8/16)
Sublingual gland 6 No (4/6)
Submandibular gland 8 No (2/132) (4/8)
Testis 16 No (2/584) (8/16)
Thalamus 6 No (2/6)
Thymus 16 No (7/16)
Thyroid gland 16 No (15/584) (4/16)
Tongue 6 No (5/127) (4/6)
Trachea 16 No (14/16)
Trigeminal V nerve 8 No (6/8)
Urinary bladder 10 No (8/10)
Uterus 16 No (8/16)
Vagina 6 No (2/6)
Vas deferens 8 No (15/388)
Vascular system 14 No (12/14)
Vesicular gland 8 No (2/8)
White adipose tissue 16 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • exocrine system(14)
    Lower Urinary Tract expression
    Prostate gland expression
    MA:0002636
    MA:0000404
  • limb(3)
    Sciatic nerve expression
    MA:0001172

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 6 (1/47) (9/9)
Axial skeleton 8 (1/51) (11/11)
Brain 22 (6/485) (27/29)
Central nervous system ganglion 8 (1/51) (11/11)
Cranium 4 (1/46) (4/4)
Dorsal root ganglion 7 (1/47) (10/10)
Ear 22 (1/485) (25/29)
Embryo 22 (1/485) (27/29)
Outer ear 6 (1/47) (9/9)
Eye 22 (1/485) (27/29)
Femur pre-cartilage condensation 4 (1/46) (4/4)
Foot 22 (1/485) (27/29)
Forearm 14 (1/282) (17/17)
Forebrain 22 (1/485) (27/29)
Forelimb 22 (1/485) (27/29)
Fronto-nasal process 7 (1/48) (9/10)
Gut 8 (1/50) (10/11)
Hand 22 (1/485) (27/29)
Head 22 (5/485) (27/29)
Head mesenchyme 6 (1/47) (9/9)
Heart 22 (1/485) (17/29)
Heart ventricle 6 (1/47) (9/9)
Hindbrain 22 (6/485) (27/29)
Hindlimb 22 (1/485) (27/29)
Humerus pre-cartilage condensation 4 (1/46) (4/4)
Inner ear 4 (1/46) (4/4)
Intestine 6 (1/47) (9/9)
Liver 22 (1/485) (16/29)
Lower leg 14 (1/282) (17/17)
Lung 22 (1/485) (15/29)
Mandibular process 22 (1/485) (25/29)
Maxillary process 22 (1/485) (25/29)
Meckel's cartilage 2 (5/5)
Mesonephros of female 4 (1/46) (3/4)
Mesonephros of male 4 (1/46) (3/4)
Metanephros 4 (1/46) (4/5)
Midbrain 22 (1/485) (27/29)
Nasal septum 6 (1/47) (9/9)
Nose 10 (1/51) (13/13)
Notochord 7 (1/47) (10/10)
Oral cavity 22 (1/485) (16/29)
Outflow tract 6 (1/47) (9/9)
Pancreas 4 (1/46) (4/4)
Pericardium 6 (1/46) (9/9)
Pharynx 4 (1/46) (4/4)
1 (7/25)
Radius-ulna pre-cartilage condensation 4 (1/46) (4/4)
Rib pre-cartilage condensation 6 (1/46) (8/8)
Skeleton 8 (1/51) (11/11)
Skin 22 (1/485) (25/29)
Spinal cord 9 (1/50) (12/12)
Stomach 4 (1/46) (4/4)
Tail 22 (1/485) (27/29)
Tail somite 22 (1/485) (27/29)
Thoracic vertebral cartilage condensation 4 (1/46) (5/5)
Tongue 4 (1/46) (5/5)
Trachea 6 (1/50) (6/6)
Trunk mesenchyme 6 (1/47) (9/9)
Umbilical artery embryonic part 4 (1/47) (4/4)
Umbilical vein embryonic part 4 (1/47) (4/4)
Upper arm 14 (1/282) (17/17)
Upper leg 14 (1/282) (17/17)
Urinary system 6 (1/50) (6/6)
Vibrissa 7 (1/47) (10/10)
  • alimentary system(2)
    Mandibular process expression
    Maxillary process expression
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • head(3)
    Eye expression
    EMAPA:16198 eye
  • limb(4)
    Forelimb expression
    EMAPA:17412 forelimb


Secondary lacZ Expression Data
postnatal mouse (23)
  • Nxntm1b(EUCOMM)Wtsi
    trachea, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    lymph node, mesenteric lymph node, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    urinary bladder, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    uterus, HET, Female, WTSI

show all 23 images

trunk (16)
  • Nxntm1b(EUCOMM)Wtsi
    trachea, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    urinary bladder, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI

show all 16 images

digestive system (4)
  • Nxntm1b(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    gall bladder, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    peyer's patch, HET, Female, WTSI
immune system (4)
  • Nxntm1b(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    lymph node, mesenteric lymph node, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    peyer's patch, HET, Female, WTSI
nervous system (3)
  • Nxntm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    striatum, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    trigeminal V nerve, peripheral nervous system, HET, Female, WTSI
urinary system (3)
  • Nxntm1b(EUCOMM)Wtsi
    urinary bladder, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    urinary bladder, HET, Male, WTSI
cardiovascular system (2)
  • Nxntm1b(EUCOMM)Wtsi
    blood vessel, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    aorta, HET, Female, WTSI
integumental system (2)
  • Nxntm1b(EUCOMM)Wtsi
    mammary gland, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    skin, HET, Female, WTSI
reproductive system (2)
  • Nxntm1b(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI
respiratory system (2)
  • Nxntm1b(EUCOMM)Wtsi
    trachea, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    lung, HET, Female, WTSI
endocrine system (1)
  • Nxntm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
exocrine system (1)
  • Nxntm1b(EUCOMM)Wtsi
    mammary gland, HET, Female, WTSI
sensory organ (1)
  • Nxntm1b(EUCOMM)Wtsi
    eye, HET, Female, WTSI

Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • Adult LacZ: LacZ Images Wholemount
    276 Images
  • X-ray: XRay Images Dorso Ventral
    152 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    59 Images
  • X-ray: XRay Images Lateral Orientation
    113 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Embryo LacZ: LacZ images section
    3 Images
  • Embryo LacZ: LacZ images wholemount
    87 Images
  • Electroretinography 2: Rod and cone PDF
    3 Images
  • Sleep Wake: Wake state (bmp file)
    21 Images
Legacy Phenotype Associated Images
Xray (91)
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI

show all 91 images

Histology Slide (5)
  • Nxntm1b(EUCOMM)Wtsi
    TS20 heart, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    TS20 liver, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    TS20 forebrain, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    TS20 chorioallantoic placenta, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    TS20 skin, HET, Male, WTSI
Embryo Dysmorphology (2)
  • Nxntm1b(EUCOMM)Wtsi
    HOM, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nxntm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nxnem1(IMPC)Bay Exon Deletion
Vector
Gene
Nxnem1(IMPC)J Indel
Vector
Gene
Nxntm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Nxnem1(IMPC)Mbp Null reporter
Vector
Gene
Fixed Tissue
Nxntm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene