Gene: Nxn

Name nucleoredoxin

Synonyms l11Jus13

Status ES CellsMice
tm1a
Mice
em1
Mice
em1
Mice
tm1b
phenotype data available

Links MGI:109331   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Nxn

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nxn data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
abnormal craniofacial morphology Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal embryo size Nxnem1Bay HOM Female Male embryonic day 18.5 0.0
abnormal embryo size Nxnem1J HOM Female Male embryonic day 18.5 0.0
abnormal facial morphology Nxnem1Bay HOM Female Male embryonic day 18.5 0.0
abnormal facial morphology Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal facial morphology Nxnem1J HOM Female Male embryonic day 18.5 0.0
abnormal head shape Nxnem1Bay HOM Female Male embryonic day 18.5 0.0
abnormal head shape Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal head size Nxnem1Bay HOM Female Male embryonic day 18.5 0.0
abnormal head size Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
anophthalmia Nxntm1a(EUCOMM)Wtsi HET Female postnatal 0.0
cleft palate Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 15.5 0.0
cleft palate Nxnem1J HOM Female Male embryonic day 18.5 0.0
cleft palate Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
embryonic lethality prior to tooth bud stage Nxnem1Mbp HOM Female Male embryonic day 12.5 0.0
embryonic lethality prior to tooth bud stage Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 12.5 0.0
facial cleft Nxnem1Bay HOM Female Male embryonic day 18.5 0.0
facial cleft Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 18.5 0.0
facial cleft Nxnem1J HOM Male embryonic day 18.5 0.0
prenatal lethality prior to heart atrial septation Nxnem1Mbp HOM Female Male embryonic day 14.5 0.0
prenatal lethality prior to heart atrial septation Nxntm1b(EUCOMM)Wtsi HOM Female Male embryonic day 14.5 0.0
preweaning lethality, complete penetrance Nxnem1Bay HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Nxntm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Nxnem1J HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Nxnem1Mbp HOM Female Male n/a 0.0
small adrenal glands Nxntm1b(EUCOMM)Wtsi HET Male postnatal 0.0
short tibia Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 7.94E-7
abnormal snout morphology Nxntm1b(EUCOMM)Wtsi HET Female postnatal 6.1E-6
decreased lean body mass Nxntm1b(EUCOMM)Wtsi HET Female postnatal 1.25E-5
abnormal bone structure Nxntm1b(EUCOMM)Wtsi HET Female Male postnatal 1.85E-5
abnormal eyelid morphology Nxntm1b(EUCOMM)Wtsi HET Female postnatal 2.03E-5
increased grip strength Nxntm1a(EUCOMM)Wtsi HET Female Male postnatal 2.36E-5
abnormal cranium morphology Nxntm1b(EUCOMM)Wtsi HET Female postnatal 2.7E-5
prolonged PQ interval Nxnem1J HET Female postnatal 2.84E-5
increased or absent threshold for auditory brainstem response Nxntm1b(EUCOMM)Wtsi HET Female postnatal 7.33E-5
abnormal bone structure Nxnem1J HET Male postnatal 7.65E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/176) (2/2)
Adrenal gland 14 No (2/354) (11/14)
Aorta 16 No (2/530) (13/16)
Blood 2 No
Blood vessel 2 No (2/2)
Bone 12 No (1/515) (2/12)
Bone marrow 2 No
Brain 16 No (8/530) (16/16)
Brainstem 16 No (5/530) (10/16)
Brown adipose tissue 2 No
Brown adipose tissue 12 No
Cartilage tissue 16 No (1/530) (10/16)
Cecum 8 No (1/325) (6/8)
Cerebellum 16 No (6/530) (9/16)
Cerebral cortex 16 No (6/530) (8/16)
Chest bone 6 No (4/6)
Colon 6 No (1/99) (4/6)
Cranium 6 No
Diaphragm 6 No (4/6)
Duodenum 4 No (1/99) (4/4)
Epididymis 8 No (1/103) (1/8)
Esophagus 14 No (1/354) (12/14)
Eye 16 No (1/530) (12/16)
Gall bladder 12 No (10/12)
Gonadal fat pad 4 No
Harderian gland 6 No (4/6)
Heart 16 No (4/530) (6/16)
Hindlimb 6 No (4/6)
Hippocampus 16 No (7/530) (8/16)
Hypothalamus 16 No (5/529) (8/16)
Ileum 4 No (1/99) (4/4)
Jejunum 4 No (1/99) (4/4)
Kidney 16 No (13/530) (16/16)
Large intestine 16 No (7/530) (14/16)
Liver 16 No (2/16)
Lower urinary tract 16 No (3/530) (11/16)
Lung 16 No (4/530) (15/16)
Lymph node 16 No (2/530) (6/16)
Main olfactory bulb 6 No (4/6)
Mammary gland 16 No (7/16)
Mesenteric lymph node 8 No (2/8)
Mesenteric adipose tissue 4 No (4/4)
Midbrain 6 No (6/6)
Esophagus 2 No (2/2)
Olfactory lobe 14 No (3/354) (8/14)
Olfactory lobe 2 No (2/176) (2/2)
Oral epithelium 10 No (4/10)
Ovary 16 No (1/530) (7/16)
Oviduct 16 No (1/530) (7/16)
Pancreas 16 No (2/530) (1/16)
Parathyroid gland 12 No (2/516) (2/12)
Parotid gland 6 No (4/6)
Penis 6 No (2/6)
Peripheral nervous system 16 No (4/530) (13/16)
Peyer's patch 2 No (1/176) (2/2)
Peyer's patch 14 No (1/354) (4/14)
Pituitary gland 16 No (2/530) (12/16)
Prostate gland 16 No (3/530) (6/16)
Quadriceps 4 No (4/4)
Sciatic nerve 6 No (4/6)
Skeletal muscle 14 No (12/14)
Skeletal muscle tissue 2 No (2/2)
Skin 16 No (2/530) (14/16)
Small intestine 16 No (5/530) (14/16)
Spinal cord 16 No (5/530) (14/16)
Spleen 16 No (3/530) (6/16)
Stomach 16 No (5/530) (15/16)
Stomach pyloric region 6 No
Striatum 16 No (6/530) (8/16)
Sublingual gland 6 No (4/6)
Submandibular gland 8 No (4/8)
Testis 16 No (7/530) (8/16)
Thalamus 6 No (2/6)
Thymus 16 No (1/530) (7/16)
Thyroid gland 16 No (11/530) (4/16)
Tongue 6 No (4/6)
Trachea 16 No (5/530) (14/16)
Trigeminal V nerve 8 No (6/8)
Urinary bladder 10 No (8/10)
Uterus 16 No (1/530) (8/16)
Vagina 6 No (2/6)
Vas deferens 8 No (1/331)
Vascular system 14 No (1/354) (12/14)
Vesicular gland 8 No (2/8)
White adipose tissue 16 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • exocrine system(14)
    Lower Urinary Tract expression
    Prostate gland expression
    MA:0002636
    MA:0000404
  • limb(3)
    Sciatic nerve expression
    MA:0001172

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 4 No Data (4/5)
Axial skeleton 4 No Data (4/5)
Brain 19 (5/413) (19/24)
Central nervous system ganglion 4 No Data (4/5)
Cranium 4 No Data (4/5)
Dorsal root ganglion 4 No Data (4/5)
Ear 19 (17/24)
Embryo 19 (19/24)
Outer ear 4 No Data (4/5)
Eye 19 (19/24)
Femur pre-cartilage condensation 4 No Data (4/5)
Foot 19 (19/24)
Forearm 12 (12/13)
Forebrain 19 (19/24)
Forelimb 19 (19/24)
Fronto-nasal process 4 (4/5)
Gut 4 No Data (4/5)
Hand 19 (19/24)
Head 19 (4/413) (19/24)
Head mesenchyme 4 No Data (4/5)
Heart 19 (9/24)
Heart ventricle 4 No Data (4/5)
Hindbrain 19 (5/413) (19/24)
Hindlimb 19 (19/24)
Humerus pre-cartilage condensation 4 No Data (4/5)
Inner ear 4 No Data (4/5)
Intestine 4 No Data (4/5)
Liver 19 (9/24)
Lower leg 12 (12/13)
Lung 19 (9/24)
Mandibular process 19 (17/24)
Maxillary process 19 (17/24)
Mesonephros of female 4 No Data (3/5)
Mesonephros of male 4 No Data (3/5)
Metanephros 4 No Data (4/5)
Midbrain 19 (19/24)
Nasal septum 4 No Data (4/5)
Nose 5 No Data (5/6)
Notochord 5 No Data (5/6)
Oral cavity 19 (9/24)
Outflow tract 4 No Data (4/5)
Pancreas 4 No Data (4/5)
Pericardium 4 No Data (4/5)
Pharynx 4 No Data (4/5)
Radius-ulna pre-cartilage condensation 4 No Data (4/5)
Rib pre-cartilage condensation 4 No Data (4/5)
Skeleton 4 No Data (4/5)
Skin 19 (17/24)
Spinal cord 4 No Data (4/5)
Stomach 4 No Data (4/5)
Tail 19 (19/24)
Tail somite 19 (19/24)
Thoracic vertebral cartilage condensation 4 No Data (4/5)
Tongue 4 No Data (4/5)
Trachea 4 No Data (4/5)
Trunk mesenchyme 4 No Data (4/5)
Umbilical artery embryonic part 4 No Data (4/5)
Umbilical vein embryonic part 4 No Data (4/5)
Upper arm 12 (12/13)
Upper leg 12 (12/13)
Urinary system 4 No Data (4/5)
Vibrissa 5 No Data (5/6)
  • alimentary system(2)
    Mandibular process expression
    Maxillary process expression
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • head(3)
    Eye expression
    EMAPA:16198 eye
  • limb(4)
    Forelimb expression
    EMAPA:17412 forelimb


Secondary lacZ Expression Data
trunk (16)
  • Nxntm1b(EUCOMM)Wtsi
    AORTA, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    GALL BLADDER, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    URINARY BLADDER, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    URINARY BLADDER, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI

show all 16 images

digestive system (4)
  • Nxntm1b(EUCOMM)Wtsi
    GALL BLADDER, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    ESOPHAGUS, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
immune system (4)
  • Nxntm1b(EUCOMM)Wtsi
    LYMPH NODE, MESENTERIC LYMPH NODE, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    THYMUS, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    SPLEEN, HET, Female, WTSI
nervous system (3)
  • Nxntm1b(EUCOMM)Wtsi
    STRIATUM, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    TRIGEMINAL V NERVE, PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
urinary system (3)
  • Nxntm1b(EUCOMM)Wtsi
    URINARY BLADDER, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    URINARY BLADDER, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
cardiovascular system (2)
  • Nxntm1b(EUCOMM)Wtsi
    AORTA, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    BLOOD VESSEL, HET, Female, WTSI
integumental system (2)
  • Nxntm1b(EUCOMM)Wtsi
    SKIN, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    MAMMARY GLAND, HET, Female, WTSI
reproductive system (2)
  • Nxntm1b(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    UTERUS, HET, Female, WTSI
respiratory system (2)
  • Nxntm1b(EUCOMM)Wtsi
    TRACHEA, HET, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    LUNG, HET, Female, WTSI
endocrine system (1)
  • Nxntm1b(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
exocrine system (1)
  • Nxntm1b(EUCOMM)Wtsi
    MAMMARY GLAND, HET, Female, WTSI
sensory organ (1)
  • Nxntm1b(EUCOMM)Wtsi
    EYE, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    181 Images
  • Eye Morphology: Images Ophthalmoscopy
    5 Images
  • Adult LacZ: LacZ Images Section
    66 Images
  • X-ray: XRay Images Lateral Orientation
    143 Images
  • X-ray: XRay Images Skull Lateral Orientation
    79 Images
  • Eye Morphology: Images Slit Lamp
    2 Images
  • Gross Pathology and Tissue Collection
    8 Images
  • Adult LacZ: LacZ Images Wholemount
    276 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    75 Images
  • Echo: M-Mode Images
    32 Images
Legacy Phenotype Associated Images
Xray (91)
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI

show all 91 images

Histology Slide (5)
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HET, Male, WTSI
Embryo Dysmorphology (2)
  • Nxntm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Nxntm1b(EUCOMM)Wtsi
    HOM, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Nxntm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nxnem1(IMPC)J Deletion of an Exon / Partial Exon deletion
Vector
Gene
Nxnem1(IMPC)Mbp Wild type floxed exon
Vector
Gene
Nxntm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Nxntm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene