Gene: Nptn

Name neuroplastin

Synonyms Sdfr1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:108077   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Nptn

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nptn data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal ear morphology Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.1E-23
decreased prepulse inhibition Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 7.03E-18
abnormal behavior Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.54E-10
abnormal gait Nptntm1b(EUCOMM)Hmgu HOM Female postnatal 5.09E-9
hyperactivity Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.11E-7
absent startle reflex Nptntm1b(EUCOMM)Hmgu HOM Male postnatal 1.61E-6
increased or absent threshold for auditory brainstem response Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.0E-6
tremors Nptntm1b(EUCOMM)Hmgu HOM Female postnatal 5.21E-6
increased bone mineral content Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.95E-6
decreased startle reflex Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 6.2E-6
increased mean corpuscular volume Nptntm1b(EUCOMM)Hmgu HOM Female postnatal 8.0E-6
increased circulating iron level Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.33E-5
increased hemoglobin content Nptntm1b(EUCOMM)Hmgu HOM Female postnatal 1.8E-5
decreased total body fat amount Nptntm1b(EUCOMM)Hmgu HOM Male postnatal 4.22E-5
increased heart weight Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.04E-5
increased circulating cholesterol level Nptntm1b(EUCOMM)Hmgu HOM Female Male postnatal 9.97E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/354) (4/4)
Aorta 4 No (2/530) (4/4)
Bone 4 No (1/515) (4/4)
Brain 4 No (8/530) (4/4)
Brainstem 4 No (5/530)
Brown adipose tissue 4 No
Cartilage tissue 4 No (1/530) (4/4)
Cerebellum 4 No (6/530) (4/4)
Cerebral cortex 4 No (6/530) (4/4)
Esophagus 4 No (1/354) (2/4)
Eye 4 No (1/530) (2/4)
Gall bladder 4 No (2/4)
Heart 4 No (4/530) (4/4)
Hippocampus 4 No (7/530)
Hypothalamus 4 No (5/529)
Kidney 4 No (13/530) (4/4)
Large intestine 4 No (7/530) (4/4)
Liver 4 No
Lower urinary tract 4 No (3/530) (4/4)
Lung 4 No (4/530) (2/4)
Lymph node 4 No (2/530)
Mammary gland 4 No
Olfactory lobe 4 No (3/354)
Oral epithelium 4 No
Ovary 4 No (1/530)
Oviduct 4 No (1/530) (1/4)
Pancreas 4 No (2/530)
Parathyroid gland 4 No (2/516)
Peripheral nervous system 4 No (4/530) (4/4)
Peyer's patch 4 No (1/354)
Pituitary gland 4 No (2/530)
Prostate gland 4 No (3/530)
Skeletal muscle 4 No
Skin 4 No (2/530) (2/4)
Small intestine 4 No (5/530) (3/4)
Spinal cord 4 No (5/530) (3/4)
Spleen 4 No (3/530)
Stomach 4 No (5/530) (4/4)
Striatum 4 No (6/530) (1/4)
Testis 4 No (7/530) (3/4)
Thymus 4 No (1/530)
Thyroid gland 4 No (11/530)
Trachea 4 No (5/530) (4/4)
Uterus 4 No (1/530) (1/4)
Vascular system 4 No (1/354) (4/4)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/413) (2/4)
Ear 2
Embryo 2 (4/4)
Eye 2 (3/4)
Foot 2 (2/4)
Forebrain 2 (2/4)
Forelimb 2
Hand 2 (1/4)
Head 2 (4/413) (2/4)
Heart 2 (2/4)
Hindbrain 2 (5/413) (1/4)
Hindlimb 2
Liver 2 (1/4)
Lung 2
Mandibular process 2
Maxillary process 2
Midbrain 2
Oral cavity 2
Skin 2
Tail 2 (1/4)
Tail somite 2


Associated Images

Associated Images
  • Echo: M-Mode Images
    64 Images
  • X-ray: XRay Images Lateral Orientation
    13 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Dorso Ventral
    13 Images
  • Adult LacZ: LacZ Images Wholemount
    23 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Nptntm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nptntm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene