Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Gata6 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Tetralogy Of Fallot | Intrauterine growth retardation | ORPHA:3303 | |
Heart Defects, Congenital, And Other Congenital Anomalies | Umbilical hernia, Patent ductus arteriosus, Intrauterine growth retardation | OMIM:600001 | |
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome | Umbilical hernia, Patent ductus arteriosus, Intrauterine growth retardation | ORPHA:2255 | |
Atrioventricular Septal Defect 5 | OMIM:614474 | ||
Tetralogy Of Fallot | OMIM:187500 | ||
Atrial Septal Defect 9 | OMIM:614475 | ||
Congenital Diaphragmatic Hernia | ORPHA:2140 | ||
Conotruncal Heart Malformations | OMIM:217095 | ||
Atrial Septal Defect, Ostium Secundum Type | ORPHA:99103 | ||
Familial Atrial Fibrillation | ORPHA:334 |
The table below shows human diseases predicted to be associated to Gata6 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Tetralogy Of Fallot | Intrauterine growth retardation | ORPHA:3303 | |
Heart Defects, Congenital, And Other Congenital Anomalies | Umbilical hernia, Patent ductus arteriosus, Intrauterine growth retardation | OMIM:600001 | |
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome | Umbilical hernia, Patent ductus arteriosus, Intrauterine growth retardation | ORPHA:2255 | |
Atrioventricular Septal Defect 5 | OMIM:614474 | ||
Tetralogy Of Fallot | OMIM:187500 | ||
Atrial Septal Defect 9 | OMIM:614475 | ||
Congenital Diaphragmatic Hernia | ORPHA:2140 | ||
Conotruncal Heart Malformations | OMIM:217095 | ||
Atrial Septal Defect, Ostium Secundum Type | ORPHA:99103 | ||
Familial Atrial Fibrillation | ORPHA:334 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Gata6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Gata6tm108362(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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