Gene: Lepr

Order

Name leptin receptor

Synonyms
  • OB-RGRP
  • leptin receptor gene-related protein
  • Obr
  • obl
  • Modb1
  • Leprb
  • LEPROT
  • obese-like

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:104993    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Lepr

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lepr data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Liver - lipid deposition Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
Pancreas - hypertrophy Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
Skeletal muscle - fatty infiltration Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
Skin - hypertrophy Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
female infertility Leprtm1b(EUCOMM)Wtsi HOM Female postpartum stage 0.0
male infertility Leprtm1b(EUCOMM)Wtsi HOM Male postpartum stage 0.0
hypoactivity Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.07E-29
abnormal behavior Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.44E-27
limb grasping Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 6.13E-23
trunk curl Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 6.15E-23
impaired righting response Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.83E-21
increased monocyte cell number Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.26E-18
abnormal gait Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 7.69E-18
abnormal locomotor behavior Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.24E-16
tremors Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 8.54E-16
increased hematocrit Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.01E-11
increased mean platelet volume Leprtm1b(EUCOMM)Wtsi HOM Male postnatal 1.58E-11
decreased lymphocyte cell number Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.59E-11
thrombocytopenia Leprtm1b(EUCOMM)Wtsi HOM Male postnatal 2.12E-11
decreased leukocyte cell number Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 6.7E-8
increased hemoglobin content Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.68E-6
increased neutrophil cell number Leprtm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.28E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No
Bone 2 No (2/2)
Brain 2 No (1/2)
Brainstem 2 No (1/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No
Lymph node 2 No (2/2)
Mammary gland 2 No
Olfactory lobe 2 No
Oral epithelium 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
Vascular system 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    nervous system
    reproductive system
    immune system
    musculoskeletal system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/4)
Ear 2 (1/485)
Embryo 2 (1/485) (4/4)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Hand 2 (1/485)
Head 2 (5/485) (4/4)
Heart 2 (1/485)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485) (1/4)
Maxillary process 2 (1/485)
Midbrain 2 (1/485) (2/4)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Tail 2 (1/485) (3/4)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    8 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Leprtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Leprtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Leprtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene