Gene: Nsf

Order

Name N-ethylmaleimide sensitive fusion protein

Synonyms
  • N-ethylmaleimide sensitive factor
  • SKD2

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:104560    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Nsf

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nsf data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Nsftm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
preweaning lethality, complete penetrance Nsftm1b(KOMP)Mbp HOM Female Male n/a 0.0
increased hemoglobin content Nsftm1b(KOMP)Mbp HET Female Male postnatal 5.83E-7
decreased grip strength Nsftm1b(KOMP)Mbp HET Female Male postnatal 8.56E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone marrow 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415)
Eye 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 1 (1/51) (1/1)
Brain 2 (6/485) (2/2)
Dorsal root ganglion 1 (1/47) Image Only
Ear 2 (1/485) (2/2)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485) (2/2)
Foot 2 (1/485) (2/2)
Forebrain 2 (1/485) (1/2)
Forelimb 2 (1/485) (2/2)
Fronto-nasal process 1 (1/48) Image Only
Hand 2 (1/485) (2/2)
Head 2 (5/485) (2/2)
Heart 2 (1/485) (2/2)
Hindbrain 2 (6/485) (2/2)
Hindlimb 2 (1/485) (2/2)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485) (2/2)
Maxillary process 2 (1/485) (2/2)
Midbrain 2 (1/485) (1/2)
Nose 1 (1/51) (1/1)
Oral cavity 2 (1/485) (1/2)
Skeleton 1 (1/51) (1/1)
Skin 2 (1/485) (1/2)
Spinal cord 1 (1/50) (1/1)
Tail 2 (1/485) (2/2)
Tail somite 2 (1/485)
Umbilical artery embryonic part 1 (1/47) (1/1)
Umbilical vein embryonic part 1 (1/47) (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    16 Images
  • X-ray: XRay Images Forepaw
    16 Images
  • X-ray: XRay Images Lateral Orientation
    16 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    16 Images
  • X-ray: XRay Images Skull Lateral Orientation
    16 Images
  • Electroretinography: Rod waveform (pdf format)
    4 Images
  • Sleep Wake: Wake state (bmp file)
    8 Images
  • Combined SHIRPA and Dysmorphology
    2 Images
  • Electroretinography: Cone waveform (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nsftm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Nsftm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene