Gene: Cxcl12

Order

Name chemokine (C-X-C motif) ligand 12

Synonyms
  • PBSF
  • SDF-1
  • TLSF-a
  • Sdf1
  • PBSF/SDF-1
  • Scyb12
  • TLSF-b
  • Sdf1b
  • TPAR1
  • Sdf1a

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:103556    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Cxcl12

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cxcl12 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Cxcl12tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Cxcl12tm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
enlarged uterus Cxcl12tm1.1(KOMP)Vlcg HET Female postnatal 0.0
hydrometra Cxcl12tm1.1(KOMP)Vlcg HET Female postnatal 0.0
preweaning lethality, complete penetrance Cxcl12tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
small superior vagus ganglion Cxcl12tm1.1(KOMP)Vlcg HET Female postnatal 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (1/2)
Blood 2 No
Bone marrow 2 No (2/2)
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No
Cecum 2 No (12/383) (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No
Chest bone 2 No
Colon 2 No (12/127) (2/2)
Diaphragm 2 No (2/2)
Duodenum 2 No (2/127) (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Gall bladder 2 No
Gonadal fat pad 2 No (2/2)
Harderian gland 2 No (2/2)
Heart 2 No
Hindlimb 2 No
Hippocampus 2 No
Hypothalamus 2 No
Ileum 2 No (14/127) (2/2)
Jejunum 2 No (6/127) (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No (2/2)
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No (1/2)
Mesenteric lymph node 2 No (2/2)
Mesenteric adipose tissue 2 No (2/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No
Parotid gland 2 No (2/2)
Penis 2 No (1/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584) (1/2)
Quadriceps 2 No (2/2)
Sciatic nerve 2 No (1/2)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Stomach pyloric region 2 No
Striatum 2 No
Sublingual gland 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Tongue 2 No (5/127) (2/2)
Trachea 2 No (1/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vagina 2 No (1/2)
Vas deferens 2 No (15/388) (1/2)
Vascular system 2 No
Vesicular gland 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system limb digestive system cardiovascular system set of connective tissues reproductive system adipose tissue musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 3 (1/47) (3/3)
Axial skeleton 3 (1/51) (3/3)
Brain 3 (6/485) (3/3)
Central nervous system ganglion 3 (1/51) (3/3)
Dorsal root ganglion 3 (1/47) (3/3)
Ear 3 (1/485) (3/3)
Embryo 3 (1/485) (3/3)
Eye 3 (1/485) (3/3)
Foot 3 (1/485)
Forebrain 3 (1/485) (3/3)
Forelimb 3 (1/485) (3/3)
Fronto-nasal process 3 (1/48) (3/3)
Gut 3 (1/50) (3/3)
Hand 3 (1/485)
Head 3 (5/485) (3/3)
Head mesenchyme 3 (1/47) (3/3)
Heart 3 (1/485) (3/3)
Heart ventricle 3 (1/47) (3/3)
Hindbrain 3 (6/485) (1/3)
Hindlimb 3 (1/485) (3/3)
Liver 3 (1/485) (3/3)
Lung 3 (1/485) (3/3)
Mandibular process 3 (1/485) (3/3)
Maxillary process 3 (1/485) (3/3)
Meckel's cartilage 1
Midbrain 3 (1/485) (3/3)
Nasal septum 3 (1/47)
Nose 3 (1/51) (3/3)
Oral cavity 3 (1/485) (3/3)
Outflow tract 3 (1/47) (3/3)
Pericardium 2 (1/46) (2/2)
Rib pre-cartilage condensation 3 (1/46) (3/3)
Skeleton 2 (1/51) (2/2)
Skin 3 (1/485) (3/3)
Spinal cord 3 (1/50) (3/3)
Tail 3 (1/485) (3/3)
Tail somite 3 (1/485) (3/3)
Thoracic vertebral cartilage condensation 3 (1/46) (3/3)
Tongue 1 (1/46) (1/1)
Trunk mesenchyme 3 (1/47) (2/3)
Vibrissa 3 (1/47)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cxcl12tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Cxcl12tm42159(L1L2_st1)
Vector
Gene
Cxcl12tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Cxcl12tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue