Gene: Ube2b

Name ubiquitin-conjugating enzyme E2B

Synonyms
  • HR6B
  • Rad6b
  • E2-14k

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:102944   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Ube2b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ube2b data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
enlarged heart Ube2btm1b(EUCOMM)Wtsi HET Female Male postnatal 0.0
preweaning lethality, incomplete penetrance Ube2btm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
abnormal gait Ube2btm1b(EUCOMM)Wtsi HET Male postnatal 1.61E-6
abnormal gait Ube2btm1b(EUCOMM)Wtsi HOM Male postnatal 1.61E-6
limb grasping Ube2btm1b(EUCOMM)Wtsi HOM Male postnatal 3.28E-6
limb grasping Ube2btm1b(EUCOMM)Wtsi HET Male postnatal 3.28E-6
abnormal coat appearance Ube2btm1b(EUCOMM)Wtsi HOM Male postnatal 1.43E-5
abnormal coat appearance Ube2btm1b(EUCOMM)Wtsi HET Male postnatal 1.43E-5
abnormal behavior Ube2btm1a(EUCOMM)Wtsi HET Female postnatal 1.54E-5
decreased circulating triglyceride level Ube2btm1a(EUCOMM)Wtsi HET Male postnatal 6.12E-5
increased circulating triglyceride level Ube2btm1a(EUCOMM)Wtsi HET Female postnatal 6.12E-5
increased circulating alkaline phosphatase level Ube2btm1a(EUCOMM)Wtsi HET Female Male postnatal 7.79E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354) (2/2)
Aorta 2 No (2/530) (2/2)
Bone 2 No (1/515) (2/2)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/530) (2/2)
Cerebellum 2 No (6/530) (2/2)
Cerebral cortex 2 No (6/530) (2/2)
Esophagus 2 No (1/354) (2/2)
Eye 2 No (1/530) (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (4/530) (2/2)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/530) (2/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530) (2/2)
Mammary gland 2 No (1/2)
Olfactory lobe 2 No (3/354) (2/2)
Oral epithelium 2 No (2/2)
Ovary 2 No (1/530) (1/2)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530) (2/2)
Parathyroid gland 2 No (2/516) (2/2)
Peripheral nervous system 2 No (4/530) (2/2)
Peyer's patch 2 No (1/354) (2/2)
Pituitary gland 2 No (2/530) (2/2)
Prostate gland 2 No (3/530) (1/2)
Skeletal muscle 2 No (2/2)
Skin 2 No (2/530) (2/2)
Small intestine 2 No (5/530) (2/2)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530) (2/2)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530) (2/2)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530) (2/2)
Thyroid gland 2 No (11/530) (2/2)
Trachea 2 No (5/530) (2/2)
Uterus 2 No (1/530) (1/2)
Vascular system 2 No (1/354) (2/2)
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (5/413) (4/4)
Ear 2 (2/4)
Embryo 2 (4/4)
Eye 2 (4/4)
Foot 2 (3/4)
Forebrain 2 (4/4)
Forelimb 2 (4/4)
Hand 2 (3/4)
Head 2 (4/413) (4/4)
Heart 2 (2/4)
Hindbrain 2 (5/413) (4/4)
Hindlimb 2 (4/4)
Liver 2 (2/4)
Lung 2 (2/4)
Mandibular process 2 (2/4)
Maxillary process 2 (2/4)
Midbrain 2 (4/4)
Oral cavity 2 (2/4)
Skin 2 (2/4)
Tail 2 (4/4)
Tail somite 2 (4/4)


Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    12 Images
  • Adult LacZ: LacZ Images Wholemount
    28 Images
  • X-ray: XRay Images Lateral Orientation
    12 Images
  • X-ray: XRay Images Dorso Ventral
    12 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Ube2btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ube2btm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Ube2btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene