Illuminating the Druggable Genome (IDG)

IDG is an NIH Common Fund project focused on collecting, integrating and making available biological data on 395 human genes from three key druggable protein families that have been identified as potential therapeutic targets: non-olfactory G-protein coupled receptors (GPCRs), ion channels, and protein kinases. The IMPC consortium is creating knockout mouse strains for the IDG project to better understand the function of these proteins.

IMPC data representation for IDG genes

IDG human genes are mapped to mouse orthologs using HomoloGene. The IMPC consortium is using different complementary targeting strategies to produce Knockout strains. Mice are produced and submitted to standardised phenotyping pipelines. Currently 77.4 % of mouse IDG gene have data representation in IMPC, the bar charts and heatmap below capture the IMPC data representation at different levels. The percentage might increase as we get more data and this page will reflect the change.

IMPC IDG data Heat Map

The heat map indicates the detailed IDG gene data representation in IMPC, from product availability to phenotypes. Phenotypes are grouped by biological systems.

Phenotype Associations

The following chord diagrams represent the various biological systems phenotype associations for IDG genes categorized both in all and in each family group. The line thickness is correlated with the strength of the association. Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.

All families

Ion channels