Home IMPC data collections IDG Illuminating the Druggable Genome (IDG) IDG is an NIH Common Fund project focused on collecting, integrating and making available biological data on 278 human genes from three key druggable protein families that have been identified as potential therapeutic targets: non-olfactory G-protein coupled receptors (GPCRs), ion channels, and protein kinases. The IMPC consortium is creating knockout mouse strains for the IDG project to better understand the function of these proteins.
IMPC data representation for IDG genes IDG human genes are mapped to mouse orthologs using HCOP . The IMPC consortium is using different complementary targeting strategies to produce Knockout strains. Mice are produced and submitted to standardised phenotyping pipelines. Currently 63.7 % of mouse IDG gene have data representation in IMPC, the bar charts and heatmap below capture the IMPC data representation at different levels. The percentage might increase as we get more data and this page will reflect the change.
IMPC IDG data Heat Map The heat map indicates the detailed IDG gene data representation in IMPC, from product availability to phenotypes. Phenotypes are grouped by biological systems.
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Phenotype Associations The following chord diagrams represent the various biological systems phenotype associations for IDG genes categorized both in all and in each family group. The line thickness is correlated with the strength of the association. Clicking on chosen phenotype(s) on the diagram allow to select common genes. Corresponding gene lists can be downloaded using the download icon.
All families 132 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.Get the genes and associated phenotypes.
limbs/digits/tail cardiovascular system liver/biliary system respiratory system hematopoietic system nervous system adipose tissue digestive/alimentary craniofacial muscle behavior/neurological homeostasis/metabolism endocrine/exocrine gland integument renal/urinary system skeleton mortality/aging growth/size/body region vision/eye hearing/vestibular/ear embryo immune system reproductive system 2 genes present limbs/digits/tail phenotype and cardiovascular system phenotype, 1 genes present limbs/digits/tail phenotype and liver/biliary system phenotype, 3 genes present limbs/digits/tail phenotype and hematopoietic system phenotype, 1 genes present limbs/digits/tail phenotype and nervous system phenotype, 1 genes present limbs/digits/tail phenotype and adipose tissue phenotype, 1 genes present limbs/digits/tail phenotype and digestive/alimentary phenotype, 3 genes present limbs/digits/tail phenotype and craniofacial phenotype, 4 genes present limbs/digits/tail phenotype and behavior/neurological phenotype, 2 genes present limbs/digits/tail phenotype and homeostasis/metabolism phenotype, 1 genes present limbs/digits/tail phenotype and endocrine/exocrine gland phenotype, 2 genes present limbs/digits/tail phenotype and renal/urinary system phenotype, 4 genes present limbs/digits/tail phenotype and skeleton phenotype, 2 genes present limbs/digits/tail phenotype and mortality/aging, 4 genes present limbs/digits/tail phenotype and growth/size/body region phenotype, 3 genes present limbs/digits/tail phenotype and vision/eye phenotype, 2 genes present limbs/digits/tail phenotype and embryo phenotype, 3 genes present limbs/digits/tail phenotype and immune system phenotype, 1 genes present limbs/digits/tail phenotype and reproductive system phenotype, 5 genes present cardiovascular system phenotype and cardiovascular system phenotype, 2 genes present cardiovascular system phenotype and liver/biliary system phenotype, 1 genes present cardiovascular system phenotype and respiratory system phenotype, 6 genes present cardiovascular system phenotype and hematopoietic system phenotype, 7 genes present cardiovascular system phenotype and nervous system phenotype, 3 genes present cardiovascular system phenotype and adipose tissue phenotype, 1 genes present cardiovascular system phenotype and digestive/alimentary phenotype, 2 genes present cardiovascular system phenotype and craniofacial phenotype, 2 genes present cardiovascular system phenotype and muscle phenotype, 7 genes present cardiovascular system phenotype and behavior/neurological phenotype, 8 genes present cardiovascular system phenotype and homeostasis/metabolism phenotype, 5 genes present cardiovascular system phenotype and endocrine/exocrine gland phenotype, 5 genes present cardiovascular system phenotype and integument phenotype, 5 genes present cardiovascular system phenotype and renal/urinary system phenotype, 1 genes present cardiovascular system phenotype and skeleton phenotype, 8 genes present cardiovascular system phenotype and mortality/aging, 17 genes present cardiovascular system phenotype and growth/size/body region phenotype, 10 genes present cardiovascular system phenotype and vision/eye phenotype, 2 genes present cardiovascular system phenotype and hearing/vestibular/ear phenotype, 3 genes present cardiovascular system phenotype and embryo phenotype, 4 genes present cardiovascular system phenotype and immune system phenotype, 8 genes present cardiovascular system phenotype and reproductive system phenotype, 4 genes present liver/biliary system phenotype and hematopoietic system phenotype, 2 genes present liver/biliary system phenotype and nervous system phenotype, 1 genes present liver/biliary system phenotype and adipose tissue phenotype, 2 genes present liver/biliary system phenotype and behavior/neurological phenotype, 1 genes present liver/biliary system phenotype and homeostasis/metabolism phenotype, 3 genes present liver/biliary system phenotype and endocrine/exocrine gland phenotype, 5 genes present liver/biliary system phenotype and integument phenotype, 3 genes present liver/biliary system phenotype and renal/urinary system phenotype, 1 genes present liver/biliary system phenotype and skeleton phenotype, 2 genes present liver/biliary system phenotype and mortality/aging, 5 genes present liver/biliary system phenotype and growth/size/body region phenotype, 4 genes present liver/biliary system phenotype and vision/eye phenotype, 2 genes present liver/biliary system phenotype and embryo phenotype, 4 genes present liver/biliary system phenotype and immune system phenotype, 2 genes present liver/biliary system phenotype and reproductive system phenotype, 1 genes present respiratory system phenotype and behavior/neurological phenotype, 1 genes present respiratory system phenotype and homeostasis/metabolism phenotype, 1 genes present respiratory system phenotype and endocrine/exocrine gland phenotype, 1 genes present respiratory system phenotype and skeleton phenotype, 2 genes present respiratory system phenotype and growth/size/body region phenotype, 1 genes present respiratory system phenotype and reproductive system phenotype, 2 genes present hematopoietic system phenotype and nervous system phenotype, 5 genes present hematopoietic system phenotype and adipose tissue phenotype, 2 genes present hematopoietic system phenotype and digestive/alimentary phenotype, 2 genes present hematopoietic system phenotype and craniofacial phenotype, 19 genes present hematopoietic system phenotype and behavior/neurological phenotype, 21 genes present hematopoietic system phenotype and homeostasis/metabolism phenotype, 8 genes present hematopoietic system phenotype and endocrine/exocrine gland phenotype, 8 genes present hematopoietic system phenotype and integument phenotype, 8 genes present hematopoietic system phenotype and renal/urinary system phenotype, 12 genes present hematopoietic system phenotype and skeleton phenotype, 13 genes present hematopoietic system phenotype and mortality/aging, 15 genes present hematopoietic system phenotype and growth/size/body region phenotype, 10 genes present hematopoietic system phenotype and vision/eye phenotype, 4 genes present hematopoietic system phenotype and hearing/vestibular/ear phenotype, 4 genes present hematopoietic system phenotype and embryo phenotype, 27 genes present hematopoietic system phenotype and immune system phenotype, 8 genes present hematopoietic system phenotype and reproductive system phenotype, 1 genes present nervous system phenotype and nervous system phenotype, 1 genes present nervous system phenotype and adipose tissue phenotype, 1 genes present nervous system phenotype and craniofacial phenotype, 6 genes present nervous system phenotype and behavior/neurological phenotype, 4 genes present nervous system phenotype and homeostasis/metabolism phenotype, 2 genes present nervous system phenotype and integument phenotype, 2 genes present nervous system phenotype and renal/urinary system phenotype, 2 genes present nervous system phenotype and skeleton phenotype, 4 genes present nervous system phenotype and mortality/aging, 4 genes present nervous system phenotype and growth/size/body region phenotype, 5 genes present nervous system phenotype and vision/eye phenotype, 2 genes present nervous system phenotype and hearing/vestibular/ear phenotype, 2 genes present nervous system phenotype and embryo phenotype, 1 genes present nervous system phenotype and immune system phenotype, 3 genes present nervous system phenotype and reproductive system phenotype, 1 genes present adipose tissue phenotype and craniofacial phenotype, 6 genes present adipose tissue phenotype and behavior/neurological phenotype, 4 genes present adipose tissue phenotype and homeostasis/metabolism phenotype, 2 genes present adipose tissue phenotype and endocrine/exocrine gland phenotype, 3 genes present adipose tissue phenotype and integument phenotype, 1 genes present adipose tissue phenotype and renal/urinary system phenotype, 3 genes present adipose tissue phenotype and skeleton phenotype, 1 genes present adipose tissue phenotype and mortality/aging, 9 genes present adipose tissue phenotype and growth/size/body region phenotype, 3 genes present adipose tissue phenotype and vision/eye phenotype, 1 genes present adipose tissue phenotype and embryo phenotype, 4 genes present adipose tissue phenotype and immune system phenotype, 2 genes present adipose tissue phenotype and reproductive system phenotype, 1 genes present digestive/alimentary phenotype and craniofacial phenotype, 2 genes present digestive/alimentary phenotype and behavior/neurological phenotype, 1 genes present digestive/alimentary phenotype and integument phenotype, 2 genes present digestive/alimentary phenotype and skeleton phenotype, 2 genes present digestive/alimentary phenotype and mortality/aging, 1 genes present digestive/alimentary phenotype and growth/size/body region phenotype, 1 genes present digestive/alimentary phenotype and vision/eye phenotype, 1 genes present digestive/alimentary phenotype and embryo phenotype, 2 genes present digestive/alimentary phenotype and immune system phenotype, 1 genes present digestive/alimentary phenotype and reproductive system phenotype, 3 genes present craniofacial phenotype and behavior/neurological phenotype, 2 genes present craniofacial phenotype and homeostasis/metabolism phenotype, 1 genes present craniofacial phenotype and endocrine/exocrine gland phenotype, 3 genes present craniofacial phenotype and skeleton phenotype, 1 genes present craniofacial phenotype and mortality/aging, 4 genes present craniofacial phenotype and growth/size/body region phenotype, 3 genes present craniofacial phenotype and vision/eye phenotype, 1 genes present craniofacial phenotype and hearing/vestibular/ear phenotype, 1 genes present craniofacial phenotype and embryo phenotype, 1 genes present craniofacial phenotype and immune system phenotype, 1 genes present craniofacial phenotype and reproductive system phenotype, 1 genes present muscle phenotype and behavior/neurological phenotype, 1 genes present muscle phenotype and homeostasis/metabolism phenotype, 1 genes present muscle phenotype and mortality/aging, 2 genes present muscle phenotype and growth/size/body region phenotype, 6 genes present behavior/neurological phenotype and behavior/neurological phenotype, 20 genes present behavior/neurological phenotype and homeostasis/metabolism phenotype, 4 genes present behavior/neurological phenotype and endocrine/exocrine gland phenotype, 4 genes present behavior/neurological phenotype and integument phenotype, 4 genes present behavior/neurological phenotype and renal/urinary system phenotype, 13 genes present behavior/neurological phenotype and skeleton phenotype, 9 genes present behavior/neurological phenotype and mortality/aging, 14 genes present behavior/neurological phenotype and growth/size/body region phenotype, 11 genes present behavior/neurological phenotype and vision/eye phenotype, 5 genes present behavior/neurological phenotype and hearing/vestibular/ear phenotype, 5 genes present behavior/neurological phenotype and embryo phenotype, 15 genes present behavior/neurological phenotype and immune system phenotype, 7 genes present behavior/neurological phenotype and reproductive system phenotype, 9 genes present homeostasis/metabolism phenotype and homeostasis/metabolism phenotype, 5 genes present homeostasis/metabolism phenotype and endocrine/exocrine gland phenotype, 4 genes present homeostasis/metabolism phenotype and integument phenotype, 8 genes present homeostasis/metabolism phenotype and renal/urinary system phenotype, 11 genes present homeostasis/metabolism phenotype and skeleton phenotype, 9 genes present homeostasis/metabolism phenotype and mortality/aging, 15 genes present homeostasis/metabolism phenotype and growth/size/body region phenotype, 5 genes present homeostasis/metabolism phenotype and vision/eye phenotype, 4 genes present homeostasis/metabolism phenotype and hearing/vestibular/ear phenotype, 11 genes present homeostasis/metabolism phenotype and immune system phenotype, 5 genes present homeostasis/metabolism phenotype and reproductive system phenotype, 1 genes present endocrine/exocrine gland phenotype and endocrine/exocrine gland phenotype, 6 genes present endocrine/exocrine gland phenotype and integument phenotype, 6 genes present endocrine/exocrine gland phenotype and renal/urinary system phenotype, 1 genes present endocrine/exocrine gland phenotype and skeleton phenotype, 1 genes present endocrine/exocrine gland phenotype and mortality/aging, 7 genes present endocrine/exocrine gland phenotype and growth/size/body region phenotype, 6 genes present endocrine/exocrine gland phenotype and vision/eye phenotype, 1 genes present endocrine/exocrine gland phenotype and embryo phenotype, 7 genes present endocrine/exocrine gland phenotype and immune system phenotype, 10 genes present endocrine/exocrine gland phenotype and reproductive system phenotype, 3 genes present integument phenotype and integument phenotype, 6 genes present integument phenotype and renal/urinary system phenotype, 2 genes present integument phenotype and skeleton phenotype, 5 genes present integument phenotype and mortality/aging, 8 genes present integument phenotype and growth/size/body region phenotype, 7 genes present integument phenotype and vision/eye phenotype, 3 genes present integument phenotype and embryo phenotype, 7 genes present integument phenotype and immune system phenotype, 7 genes present integument phenotype and reproductive system phenotype, 1 genes present renal/urinary system phenotype and renal/urinary system phenotype, 3 genes present renal/urinary system phenotype and skeleton phenotype, 4 genes present renal/urinary system phenotype and mortality/aging, 7 genes present renal/urinary system phenotype and growth/size/body region phenotype, 4 genes present renal/urinary system phenotype and vision/eye phenotype, 2 genes present renal/urinary system phenotype and embryo phenotype, 8 genes present renal/urinary system phenotype and immune system phenotype, 5 genes present renal/urinary system phenotype and reproductive system phenotype, 7 genes present skeleton phenotype and mortality/aging, 7 genes present skeleton phenotype and growth/size/body region phenotype, 4 genes present skeleton phenotype and vision/eye phenotype, 2 genes present skeleton phenotype and hearing/vestibular/ear phenotype, 1 genes present skeleton phenotype and embryo phenotype, 10 genes present skeleton phenotype and immune system phenotype, 2 genes present skeleton phenotype and reproductive system phenotype, 6 genes present mortality/aging and mortality/aging, 12 genes present mortality/aging and growth/size/body region phenotype, 4 genes present mortality/aging and vision/eye phenotype, 2 genes present mortality/aging and hearing/vestibular/ear phenotype, 8 genes present mortality/aging and embryo phenotype, 9 genes present mortality/aging and immune system phenotype, 1 genes present mortality/aging and reproductive system phenotype, 8 genes present growth/size/body region phenotype and vision/eye phenotype, 2 genes present growth/size/body region phenotype and hearing/vestibular/ear phenotype, 7 genes present growth/size/body region phenotype and embryo phenotype, 11 genes present growth/size/body region phenotype and immune system phenotype, 7 genes present growth/size/body region phenotype and reproductive system phenotype, 3 genes present vision/eye phenotype and vision/eye phenotype, 1 genes present vision/eye phenotype and hearing/vestibular/ear phenotype, 2 genes present vision/eye phenotype and embryo phenotype, 10 genes present vision/eye phenotype and immune system phenotype, 8 genes present vision/eye phenotype and reproductive system phenotype, 1 genes present hearing/vestibular/ear phenotype and hearing/vestibular/ear phenotype, 2 genes present hearing/vestibular/ear phenotype and immune system phenotype, 3 genes present embryo phenotype and immune system phenotype, 1 genes present embryo phenotype and reproductive system phenotype, 1 genes present immune system phenotype and immune system phenotype, 7 genes present immune system phenotype and reproductive system phenotype, 2 genes present reproductive system phenotype and reproductive system phenotype, Ion channels IMPC/IDG genes 57 ES Cells produced 45 Mice produced 48 Phenotypes 40
View all 57 IMPC/IDG Ion Channel genes 32 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.Get the genes and associated phenotypes.
limbs/digits/tail cardiovascular system liver/biliary system respiratory system hematopoietic system adipose tissue nervous system muscle behavior/neurological endocrine/exocrine gland homeostasis/metabolism integument skeleton renal/urinary system mortality/aging vision/eye growth/size/body region hearing/vestibular/ear embryo immune system reproductive system 1 genes present limbs/digits/tail phenotype and liver/biliary system phenotype, 1 genes present limbs/digits/tail phenotype and hematopoietic system phenotype, 1 genes present limbs/digits/tail phenotype and behavior/neurological phenotype, 1 genes present limbs/digits/tail phenotype and skeleton phenotype, 1 genes present limbs/digits/tail phenotype and renal/urinary system phenotype, 1 genes present limbs/digits/tail phenotype and mortality/aging, 1 genes present limbs/digits/tail phenotype and growth/size/body region phenotype, 1 genes present limbs/digits/tail phenotype and embryo phenotype, 1 genes present limbs/digits/tail phenotype and immune system phenotype, 2 genes present cardiovascular system phenotype and cardiovascular system phenotype, 1 genes present cardiovascular system phenotype and liver/biliary system phenotype, 1 genes present cardiovascular system phenotype and respiratory system phenotype, 1 genes present cardiovascular system phenotype and hematopoietic system phenotype, 2 genes present cardiovascular system phenotype and adipose tissue phenotype, 2 genes present cardiovascular system phenotype and nervous system phenotype, 1 genes present cardiovascular system phenotype and muscle phenotype, 3 genes present cardiovascular system phenotype and behavior/neurological phenotype, 2 genes present cardiovascular system phenotype and endocrine/exocrine gland phenotype, 2 genes present cardiovascular system phenotype and homeostasis/metabolism phenotype, 1 genes present cardiovascular system phenotype and integument phenotype, 1 genes present cardiovascular system phenotype and renal/urinary system phenotype, 2 genes present cardiovascular system phenotype and mortality/aging, 3 genes present cardiovascular system phenotype and vision/eye phenotype, 4 genes present cardiovascular system phenotype and growth/size/body region phenotype, 1 genes present cardiovascular system phenotype and embryo phenotype, 1 genes present cardiovascular system phenotype and immune system phenotype, 2 genes present cardiovascular system phenotype and reproductive system phenotype, 2 genes present liver/biliary system phenotype and hematopoietic system phenotype, 1 genes present liver/biliary system phenotype and adipose tissue phenotype, 1 genes present liver/biliary system phenotype and nervous system phenotype, 1 genes present liver/biliary system phenotype and behavior/neurological phenotype, 1 genes present liver/biliary system phenotype and endocrine/exocrine gland phenotype, 1 genes present liver/biliary system phenotype and homeostasis/metabolism phenotype, 1 genes present liver/biliary system phenotype and integument phenotype, 1 genes present liver/biliary system phenotype and skeleton phenotype, 1 genes present liver/biliary system phenotype and renal/urinary system phenotype, 1 genes present liver/biliary system phenotype and mortality/aging, 1 genes present liver/biliary system phenotype and vision/eye phenotype, 3 genes present liver/biliary system phenotype and growth/size/body region phenotype, 1 genes present liver/biliary system phenotype and embryo phenotype, 2 genes present liver/biliary system phenotype and immune system phenotype, 1 genes present liver/biliary system phenotype and reproductive system phenotype, 1 genes present respiratory system phenotype and endocrine/exocrine gland phenotype, 1 genes present respiratory system phenotype and homeostasis/metabolism phenotype, 2 genes present respiratory system phenotype and growth/size/body region phenotype, 1 genes present respiratory system phenotype and reproductive system phenotype, 1 genes present hematopoietic system phenotype and adipose tissue phenotype, 3 genes present hematopoietic system phenotype and behavior/neurological phenotype, 3 genes present hematopoietic system phenotype and endocrine/exocrine gland phenotype, 3 genes present hematopoietic system phenotype and homeostasis/metabolism phenotype, 2 genes present hematopoietic system phenotype and integument phenotype, 1 genes present hematopoietic system phenotype and skeleton phenotype, 2 genes present hematopoietic system phenotype and renal/urinary system phenotype, 4 genes present hematopoietic system phenotype and mortality/aging, 4 genes present hematopoietic system phenotype and vision/eye phenotype, 4 genes present hematopoietic system phenotype and growth/size/body region phenotype, 3 genes present hematopoietic system phenotype and embryo phenotype, 6 genes present hematopoietic system phenotype and immune system phenotype, 4 genes present hematopoietic system phenotype and reproductive system phenotype, 1 genes present adipose tissue phenotype and nervous system phenotype, 3 genes present adipose tissue phenotype and behavior/neurological phenotype, 1 genes present adipose tissue phenotype and endocrine/exocrine gland phenotype, 1 genes present adipose tissue phenotype and integument phenotype, 1 genes present adipose tissue phenotype and renal/urinary system phenotype, 1 genes present adipose tissue phenotype and mortality/aging, 2 genes present adipose tissue phenotype and vision/eye phenotype, 4 genes present adipose tissue phenotype and growth/size/body region phenotype, 1 genes present adipose tissue phenotype and embryo phenotype, 2 genes present adipose tissue phenotype and immune system phenotype, 1 genes present adipose tissue phenotype and reproductive system phenotype, 1 genes present nervous system phenotype and nervous system phenotype, 1 genes present nervous system phenotype and integument phenotype, 1 genes present nervous system phenotype and mortality/aging, 1 genes present nervous system phenotype and vision/eye phenotype, 1 genes present nervous system phenotype and growth/size/body region phenotype, 1 genes present nervous system phenotype and reproductive system phenotype, 1 genes present muscle phenotype and behavior/neurological phenotype, 1 genes present muscle phenotype and homeostasis/metabolism phenotype, 1 genes present muscle phenotype and growth/size/body region phenotype, 1 genes present behavior/neurological phenotype and behavior/neurological phenotype, 2 genes present behavior/neurological phenotype and endocrine/exocrine gland phenotype, 3 genes present behavior/neurological phenotype and homeostasis/metabolism phenotype, 2 genes present behavior/neurological phenotype and integument phenotype, 1 genes present behavior/neurological phenotype and skeleton phenotype, 3 genes present behavior/neurological phenotype and renal/urinary system phenotype, 2 genes present behavior/neurological phenotype and mortality/aging, 5 genes present behavior/neurological phenotype and vision/eye phenotype, 5 genes present behavior/neurological phenotype and growth/size/body region phenotype, 1 genes present behavior/neurological phenotype and hearing/vestibular/ear phenotype, 2 genes present behavior/neurological phenotype and embryo phenotype, 3 genes present behavior/neurological phenotype and immune system phenotype, 3 genes present behavior/neurological phenotype and reproductive system phenotype, 3 genes present endocrine/exocrine gland phenotype and homeostasis/metabolism phenotype, 3 genes present endocrine/exocrine gland phenotype and integument phenotype, 2 genes present endocrine/exocrine gland phenotype and renal/urinary system phenotype, 1 genes present endocrine/exocrine gland phenotype and mortality/aging, 2 genes present endocrine/exocrine gland phenotype and vision/eye phenotype, 3 genes present endocrine/exocrine gland phenotype and growth/size/body region phenotype, 1 genes present endocrine/exocrine gland phenotype and embryo phenotype, 2 genes present endocrine/exocrine gland phenotype and immune system phenotype, 5 genes present endocrine/exocrine gland phenotype and reproductive system phenotype, 1 genes present homeostasis/metabolism phenotype and homeostasis/metabolism phenotype, 3 genes present homeostasis/metabolism phenotype and integument phenotype, 1 genes present homeostasis/metabolism phenotype and skeleton phenotype, 2 genes present homeostasis/metabolism phenotype and renal/urinary system phenotype, 1 genes present homeostasis/metabolism phenotype and mortality/aging, 2 genes present homeostasis/metabolism phenotype and vision/eye phenotype, 4 genes present homeostasis/metabolism phenotype and growth/size/body region phenotype, 1 genes present homeostasis/metabolism phenotype and immune system phenotype, 3 genes present homeostasis/metabolism phenotype and reproductive system phenotype, 3 genes present integument phenotype and renal/urinary system phenotype, 1 genes present integument phenotype and mortality/aging, 2 genes present integument phenotype and vision/eye phenotype, 3 genes present integument phenotype and growth/size/body region phenotype, 1 genes present integument phenotype and embryo phenotype, 2 genes present integument phenotype and immune system phenotype, 4 genes present integument phenotype and reproductive system phenotype, 1 genes present skeleton phenotype and renal/urinary system phenotype, 1 genes present skeleton phenotype and mortality/aging, 1 genes present skeleton phenotype and growth/size/body region phenotype, 1 genes present skeleton phenotype and embryo phenotype, 1 genes present skeleton phenotype and immune system phenotype, 2 genes present renal/urinary system phenotype and mortality/aging, 1 genes present renal/urinary system phenotype and vision/eye phenotype, 3 genes present renal/urinary system phenotype and growth/size/body region phenotype, 2 genes present renal/urinary system phenotype and embryo phenotype, 2 genes present renal/urinary system phenotype and immune system phenotype, 2 genes present renal/urinary system phenotype and reproductive system phenotype, 2 genes present mortality/aging and vision/eye phenotype, 3 genes present mortality/aging and growth/size/body region phenotype, 3 genes present mortality/aging and embryo phenotype, 2 genes present mortality/aging and immune system phenotype, 1 genes present mortality/aging and reproductive system phenotype, 3 genes present vision/eye phenotype and growth/size/body region phenotype, 1 genes present vision/eye phenotype and embryo phenotype, 4 genes present vision/eye phenotype and immune system phenotype, 3 genes present vision/eye phenotype and reproductive system phenotype, 3 genes present growth/size/body region phenotype and embryo phenotype, 4 genes present growth/size/body region phenotype and immune system phenotype, 3 genes present growth/size/body region phenotype and reproductive system phenotype, 2 genes present embryo phenotype and immune system phenotype, 1 genes present embryo phenotype and reproductive system phenotype, 3 genes present immune system phenotype and reproductive system phenotype, 2 genes present reproductive system phenotype and reproductive system phenotype, GPCRs IMPC/IDG genes 97 ES Cells produced 58 Mice produced 61 Phenotypes 48
View all 97 IMPC/IDG GPCR genes 38 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.Get the genes and associated phenotypes.
limbs/digits/tail cardiovascular system liver/biliary system hematopoietic system adipose tissue nervous system behavior/neurological homeostasis/metabolism endocrine/exocrine gland integument renal/urinary system skeleton mortality/aging hearing/vestibular/ear vision/eye growth/size/body region immune system reproductive system 1 genes present limbs/digits/tail phenotype and hematopoietic system phenotype, 1 genes present limbs/digits/tail phenotype and behavior/neurological phenotype, 1 genes present limbs/digits/tail phenotype and homeostasis/metabolism phenotype, 1 genes present limbs/digits/tail phenotype and renal/urinary system phenotype, 1 genes present limbs/digits/tail phenotype and skeleton phenotype, 1 genes present limbs/digits/tail phenotype and immune system phenotype, 2 genes present cardiovascular system phenotype and cardiovascular system phenotype, 1 genes present cardiovascular system phenotype and hematopoietic system phenotype, 1 genes present cardiovascular system phenotype and adipose tissue phenotype, 1 genes present cardiovascular system phenotype and behavior/neurological phenotype, 1 genes present cardiovascular system phenotype and homeostasis/metabolism phenotype, 2 genes present cardiovascular system phenotype and integument phenotype, 1 genes present cardiovascular system phenotype and mortality/aging, 2 genes present cardiovascular system phenotype and vision/eye phenotype, 4 genes present cardiovascular system phenotype and growth/size/body region phenotype, 1 genes present cardiovascular system phenotype and reproductive system phenotype, 1 genes present liver/biliary system phenotype and integument phenotype, 1 genes present liver/biliary system phenotype and vision/eye phenotype, 1 genes present hematopoietic system phenotype and adipose tissue phenotype, 5 genes present hematopoietic system phenotype and behavior/neurological phenotype, 6 genes present hematopoietic system phenotype and homeostasis/metabolism phenotype, 1 genes present hematopoietic system phenotype and endocrine/exocrine gland phenotype, 1 genes present hematopoietic system phenotype and integument phenotype, 2 genes present hematopoietic system phenotype and renal/urinary system phenotype, 2 genes present hematopoietic system phenotype and skeleton phenotype, 1 genes present hematopoietic system phenotype and mortality/aging, 3 genes present hematopoietic system phenotype and growth/size/body region phenotype, 7 genes present hematopoietic system phenotype and immune system phenotype, 1 genes present hematopoietic system phenotype and reproductive system phenotype, 1 genes present adipose tissue phenotype and behavior/neurological phenotype, 1 genes present adipose tissue phenotype and homeostasis/metabolism phenotype, 1 genes present adipose tissue phenotype and integument phenotype, 2 genes present adipose tissue phenotype and growth/size/body region phenotype, 1 genes present adipose tissue phenotype and reproductive system phenotype, 1 genes present nervous system phenotype and renal/urinary system phenotype, 3 genes present behavior/neurological phenotype and behavior/neurological phenotype, 6 genes present behavior/neurological phenotype and homeostasis/metabolism phenotype, 1 genes present behavior/neurological phenotype and endocrine/exocrine gland phenotype, 1 genes present behavior/neurological phenotype and integument phenotype, 1 genes present behavior/neurological phenotype and renal/urinary system phenotype, 3 genes present behavior/neurological phenotype and skeleton phenotype, 1 genes present behavior/neurological phenotype and mortality/aging, 1 genes present behavior/neurological phenotype and hearing/vestibular/ear phenotype, 1 genes present behavior/neurological phenotype and vision/eye phenotype, 3 genes present behavior/neurological phenotype and growth/size/body region phenotype, 4 genes present behavior/neurological phenotype and immune system phenotype, 1 genes present behavior/neurological phenotype and reproductive system phenotype, 1 genes present homeostasis/metabolism phenotype and homeostasis/metabolism phenotype, 3 genes present homeostasis/metabolism phenotype and renal/urinary system phenotype, 3 genes present homeostasis/metabolism phenotype and skeleton phenotype, 2 genes present homeostasis/metabolism phenotype and mortality/aging, 4 genes present homeostasis/metabolism phenotype and growth/size/body region phenotype, 5 genes present homeostasis/metabolism phenotype and immune system phenotype, 1 genes present endocrine/exocrine gland phenotype and endocrine/exocrine gland phenotype, 1 genes present endocrine/exocrine gland phenotype and immune system phenotype, 2 genes present endocrine/exocrine gland phenotype and reproductive system phenotype, 2 genes present integument phenotype and integument phenotype, 2 genes present integument phenotype and vision/eye phenotype, 1 genes present integument phenotype and growth/size/body region phenotype, 1 genes present integument phenotype and immune system phenotype, 1 genes present integument phenotype and reproductive system phenotype, 1 genes present renal/urinary system phenotype and renal/urinary system phenotype, 1 genes present renal/urinary system phenotype and skeleton phenotype, 2 genes present renal/urinary system phenotype and immune system phenotype, 2 genes present skeleton phenotype and mortality/aging, 3 genes present skeleton phenotype and immune system phenotype, 1 genes present skeleton phenotype and reproductive system phenotype, 1 genes present mortality/aging and mortality/aging, 1 genes present mortality/aging and growth/size/body region phenotype, 1 genes present mortality/aging and immune system phenotype, 2 genes present vision/eye phenotype and vision/eye phenotype, 1 genes present growth/size/body region phenotype and immune system phenotype, 1 genes present growth/size/body region phenotype and reproductive system phenotype, 2 genes present immune system phenotype and reproductive system phenotype, Kinases IMPC/IDG genes 121 ES Cells produced 97 Mice produced 78 Phenotypes 68
View all 121 IMPC/IDG Kinase genes 66 genes have phenotypes in more than one biological system. The chord diagram below shows the pleiotropy between these genes.Get the genes and associated phenotypes.
limbs/digits/tail cardiovascular system liver/biliary system hematopoietic system respiratory system nervous system adipose tissue digestive/alimentary craniofacial muscle behavior/neurological homeostasis/metabolism endocrine/exocrine gland integument renal/urinary system skeleton mortality/aging growth/size/body region vision/eye hearing/vestibular/ear embryo immune system reproductive system 2 genes present limbs/digits/tail phenotype and cardiovascular system phenotype, 1 genes present limbs/digits/tail phenotype and hematopoietic system phenotype, 1 genes present limbs/digits/tail phenotype and nervous system phenotype, 1 genes present limbs/digits/tail phenotype and adipose tissue phenotype, 1 genes present limbs/digits/tail phenotype and digestive/alimentary phenotype, 3 genes present limbs/digits/tail phenotype and craniofacial phenotype, 2 genes present limbs/digits/tail phenotype and behavior/neurological phenotype, 1 genes present limbs/digits/tail phenotype and homeostasis/metabolism phenotype, 1 genes present limbs/digits/tail phenotype and endocrine/exocrine gland phenotype, 2 genes present limbs/digits/tail phenotype and skeleton phenotype, 1 genes present limbs/digits/tail phenotype and mortality/aging, 3 genes present limbs/digits/tail phenotype and growth/size/body region phenotype, 3 genes present limbs/digits/tail phenotype and vision/eye phenotype, 1 genes present limbs/digits/tail phenotype and embryo phenotype, 1 genes present limbs/digits/tail phenotype and immune system phenotype, 1 genes present limbs/digits/tail phenotype and reproductive system phenotype, 1 genes present cardiovascular system phenotype and cardiovascular system phenotype, 1 genes present cardiovascular system phenotype and liver/biliary system phenotype, 4 genes present cardiovascular system phenotype and hematopoietic system phenotype, 5 genes present cardiovascular system phenotype and nervous system phenotype, 1 genes present cardiovascular system phenotype and digestive/alimentary phenotype, 2 genes present cardiovascular system phenotype and craniofacial phenotype, 1 genes present cardiovascular system phenotype and muscle phenotype, 3 genes present cardiovascular system phenotype and behavior/neurological phenotype, 5 genes present cardiovascular system phenotype and homeostasis/metabolism phenotype, 3 genes present cardiovascular system phenotype and endocrine/exocrine gland phenotype, 2 genes present cardiovascular system phenotype and integument phenotype, 4 genes present cardiovascular system phenotype and renal/urinary system phenotype, 1 genes present cardiovascular system phenotype and skeleton phenotype, 5 genes present cardiovascular system phenotype and mortality/aging, 9 genes present cardiovascular system phenotype and growth/size/body region phenotype, 5 genes present cardiovascular system phenotype and vision/eye phenotype, 2 genes present cardiovascular system phenotype and hearing/vestibular/ear phenotype, 2 genes present cardiovascular system phenotype and embryo phenotype, 3 genes present cardiovascular system phenotype and immune system phenotype, 5 genes present cardiovascular system phenotype and reproductive system phenotype, 2 genes present liver/biliary system phenotype and hematopoietic system phenotype, 1 genes present liver/biliary system phenotype and nervous system phenotype, 1 genes present liver/biliary system phenotype and behavior/neurological phenotype, 2 genes present liver/biliary system phenotype and endocrine/exocrine gland phenotype, 3 genes present liver/biliary system phenotype and integument phenotype, 2 genes present liver/biliary system phenotype and renal/urinary system phenotype, 1 genes present liver/biliary system phenotype and mortality/aging, 2 genes present liver/biliary system phenotype and growth/size/body region phenotype, 2 genes present liver/biliary system phenotype and vision/eye phenotype, 1 genes present liver/biliary system phenotype and embryo phenotype, 2 genes present liver/biliary system phenotype and immune system phenotype, 1 genes present liver/biliary system phenotype and reproductive system phenotype, 2 genes present hematopoietic system phenotype and nervous system phenotype, 3 genes present hematopoietic system phenotype and adipose tissue phenotype, 2 genes present hematopoietic system phenotype and digestive/alimentary phenotype, 2 genes present hematopoietic system phenotype and craniofacial phenotype, 11 genes present hematopoietic system phenotype and behavior/neurological phenotype, 12 genes present hematopoietic system phenotype and homeostasis/metabolism phenotype, 4 genes present hematopoietic system phenotype and endocrine/exocrine gland phenotype, 5 genes present hematopoietic system phenotype and integument phenotype, 4 genes present hematopoietic system phenotype and renal/urinary system phenotype, 9 genes present hematopoietic system phenotype and skeleton phenotype, 8 genes present hematopoietic system phenotype and mortality/aging, 8 genes present hematopoietic system phenotype and growth/size/body region phenotype, 6 genes present hematopoietic system phenotype and vision/eye phenotype, 4 genes present hematopoietic system phenotype and hearing/vestibular/ear phenotype, 1 genes present hematopoietic system phenotype and embryo phenotype, 14 genes present hematopoietic system phenotype and immune system phenotype, 3 genes present hematopoietic system phenotype and reproductive system phenotype, 1 genes present respiratory system phenotype and behavior/neurological phenotype, 1 genes present respiratory system phenotype and skeleton phenotype, 1 genes present nervous system phenotype and craniofacial phenotype, 6 genes present nervous system phenotype and behavior/neurological phenotype, 4 genes present nervous system phenotype and homeostasis/metabolism phenotype, 1 genes present nervous system phenotype and integument phenotype, 1 genes present nervous system phenotype and renal/urinary system phenotype, 2 genes present nervous system phenotype and skeleton phenotype, 3 genes present nervous system phenotype and mortality/aging, 3 genes present nervous system phenotype and growth/size/body region phenotype, 4 genes present nervous system phenotype and vision/eye phenotype, 2 genes present nervous system phenotype and hearing/vestibular/ear phenotype, 2 genes present nervous system phenotype and embryo phenotype, 1 genes present nervous system phenotype and immune system phenotype, 2 genes present nervous system phenotype and reproductive system phenotype, 1 genes present adipose tissue phenotype and craniofacial phenotype, 2 genes present adipose tissue phenotype and behavior/neurological phenotype, 3 genes present adipose tissue phenotype and homeostasis/metabolism phenotype, 1 genes present adipose tissue phenotype and endocrine/exocrine gland phenotype, 1 genes present adipose tissue phenotype and integument phenotype, 3 genes present adipose tissue phenotype and skeleton phenotype, 3 genes present adipose tissue phenotype and growth/size/body region phenotype, 1 genes present adipose tissue phenotype and vision/eye phenotype, 2 genes present adipose tissue phenotype and immune system phenotype, 1 genes present digestive/alimentary phenotype and craniofacial phenotype, 2 genes present digestive/alimentary phenotype and behavior/neurological phenotype, 1 genes present digestive/alimentary phenotype and integument phenotype, 2 genes present digestive/alimentary phenotype and skeleton phenotype, 2 genes present digestive/alimentary phenotype and mortality/aging, 1 genes present digestive/alimentary phenotype and growth/size/body region phenotype, 1 genes present digestive/alimentary phenotype and vision/eye phenotype, 1 genes present digestive/alimentary phenotype and embryo phenotype, 2 genes present digestive/alimentary phenotype and immune system phenotype, 1 genes present digestive/alimentary phenotype and reproductive system phenotype, 3 genes present craniofacial phenotype and behavior/neurological phenotype, 2 genes present craniofacial phenotype and homeostasis/metabolism phenotype, 1 genes present craniofacial phenotype and endocrine/exocrine gland phenotype, 3 genes present craniofacial phenotype and skeleton phenotype, 1 genes present craniofacial phenotype and mortality/aging, 4 genes present craniofacial phenotype and growth/size/body region phenotype, 3 genes present craniofacial phenotype and vision/eye phenotype, 1 genes present craniofacial phenotype and hearing/vestibular/ear phenotype, 1 genes present craniofacial phenotype and embryo phenotype, 1 genes present craniofacial phenotype and immune system phenotype, 1 genes present craniofacial phenotype and reproductive system phenotype, 1 genes present muscle phenotype and mortality/aging, 1 genes present muscle phenotype and growth/size/body region phenotype, 2 genes present behavior/neurological phenotype and behavior/neurological phenotype, 11 genes present behavior/neurological phenotype and homeostasis/metabolism phenotype, 1 genes present behavior/neurological phenotype and endocrine/exocrine gland phenotype, 1 genes present behavior/neurological phenotype and integument phenotype, 9 genes present behavior/neurological phenotype and skeleton phenotype, 6 genes present behavior/neurological phenotype and mortality/aging, 6 genes present behavior/neurological phenotype and growth/size/body region phenotype, 5 genes present behavior/neurological phenotype and vision/eye phenotype, 3 genes present behavior/neurological phenotype and hearing/vestibular/ear phenotype, 3 genes present behavior/neurological phenotype and embryo phenotype, 8 genes present behavior/neurological phenotype and immune system phenotype, 3 genes present behavior/neurological phenotype and reproductive system phenotype, 7 genes present homeostasis/metabolism phenotype and homeostasis/metabolism phenotype, 2 genes present homeostasis/metabolism phenotype and endocrine/exocrine gland phenotype, 1 genes present homeostasis/metabolism phenotype and integument phenotype, 3 genes present homeostasis/metabolism phenotype and renal/urinary system phenotype, 7 genes present homeostasis/metabolism phenotype and skeleton phenotype, 6 genes present homeostasis/metabolism phenotype and mortality/aging, 7 genes present homeostasis/metabolism phenotype and growth/size/body region phenotype, 3 genes present homeostasis/metabolism phenotype and vision/eye phenotype, 4 genes present homeostasis/metabolism phenotype and hearing/vestibular/ear phenotype, 5 genes present homeostasis/metabolism phenotype and immune system phenotype, 2 genes present homeostasis/metabolism phenotype and reproductive system phenotype, 3 genes present endocrine/exocrine gland phenotype and integument phenotype, 4 genes present endocrine/exocrine gland phenotype and renal/urinary system phenotype, 1 genes present endocrine/exocrine gland phenotype and skeleton phenotype, 4 genes present endocrine/exocrine gland phenotype and growth/size/body region phenotype, 4 genes present endocrine/exocrine gland phenotype and vision/eye phenotype, 4 genes present endocrine/exocrine gland phenotype and immune system phenotype, 3 genes present endocrine/exocrine gland phenotype and reproductive system phenotype, 1 genes present integument phenotype and integument phenotype, 3 genes present integument phenotype and renal/urinary system phenotype, 2 genes present integument phenotype and skeleton phenotype, 4 genes present integument phenotype and mortality/aging, 4 genes present integument phenotype and growth/size/body region phenotype, 3 genes present integument phenotype and vision/eye phenotype, 2 genes present integument phenotype and embryo phenotype, 4 genes present integument phenotype and immune system phenotype, 2 genes present integument phenotype and reproductive system phenotype, 1 genes present renal/urinary system phenotype and skeleton phenotype, 2 genes present renal/urinary system phenotype and mortality/aging, 4 genes present renal/urinary system phenotype and growth/size/body region phenotype, 3 genes present renal/urinary system phenotype and vision/eye phenotype, 4 genes present renal/urinary system phenotype and immune system phenotype, 3 genes present renal/urinary system phenotype and reproductive system phenotype, 4 genes present skeleton phenotype and mortality/aging, 6 genes present skeleton phenotype and growth/size/body region phenotype, 4 genes present skeleton phenotype and vision/eye phenotype, 2 genes present skeleton phenotype and hearing/vestibular/ear phenotype, 6 genes present skeleton phenotype and immune system phenotype, 1 genes present skeleton phenotype and reproductive system phenotype, 5 genes present mortality/aging and mortality/aging, 8 genes present mortality/aging and growth/size/body region phenotype, 2 genes present mortality/aging and vision/eye phenotype, 2 genes present mortality/aging and hearing/vestibular/ear phenotype, 5 genes present mortality/aging and embryo phenotype, 6 genes present mortality/aging and immune system phenotype, 5 genes present growth/size/body region phenotype and vision/eye phenotype, 2 genes present growth/size/body region phenotype and hearing/vestibular/ear phenotype, 4 genes present growth/size/body region phenotype and embryo phenotype, 6 genes present growth/size/body region phenotype and immune system phenotype, 3 genes present growth/size/body region phenotype and reproductive system phenotype, 1 genes present vision/eye phenotype and vision/eye phenotype, 1 genes present vision/eye phenotype and hearing/vestibular/ear phenotype, 1 genes present vision/eye phenotype and embryo phenotype, 6 genes present vision/eye phenotype and immune system phenotype, 5 genes present vision/eye phenotype and reproductive system phenotype, 1 genes present hearing/vestibular/ear phenotype and hearing/vestibular/ear phenotype, 2 genes present hearing/vestibular/ear phenotype and immune system phenotype, 1 genes present embryo phenotype and immune system phenotype, 1 genes present immune system phenotype and immune system phenotype, 2 genes present immune system phenotype and reproductive system phenotype, 
