Phenotype: impaired glucose tolerance

Phenotype associations stats

1.61% of tested genes with null mutations on a B6N genetic background have a phenotype association to impaired glucose tolerance (65/4032)

0.94% females (38/4022) 1.49% males (60/4023)

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Gene variants with impaired glucose tolerance

Total number of significant genotype-phenotype associations: 98

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Gck
Gckem1(IMPC)H
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 7.26E-29
Gh
Ghtm1.1(KOMP)Vlcg
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 2.65E-28
Ilrun
Ilrunem1(IMPC)Tcp
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve TCP | IMPC 4.64E-10
Sec24d
Sec24dem1(IMPC)Rbrc
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve RBRC | IMPC 8.8E-10
Ncoa3
Ncoa3tm1b(EUCOMM)Wtsi
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 2.39E-9
Fzd3
Fzd3tm1b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 6.99E-9
Ghrh
Ghrhtm1b(EUCOMM)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge UC Davis | IMPC 7.51E-9
Depdc5
Depdc5tm1b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 2.99E-8
Lama5
Lama5tm1b(KOMP)Wtsi
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 1.32E-7
Nedd4
Nedd4tm2b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 1.39E-7
Golga3
Golga3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 1.58E-7
Cacnb2
Cacnb2tm1.1(KOMP)Vlcg
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 2.16E-7
Mmgt2
Mmgt2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 2.28E-7
Ctdspl
Ctdspltm1.1(KOMP)Mbp
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 3.16E-7
Slc20a2
Slc20a2tm1b(EUCOMM)Wtsi
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve HMGU | IMPC 3.72E-7
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve HMGU | IMPC 4.4E-7
2210408I21Rik
2210408I21Riktm1b(EUCOMM)Wtsi
HOM Female postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge UC Davis | IMPC 4.71E-7
Nbr1
Nbr1tm1b(KOMP)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 4.88E-7
Nhlh2
Nhlh2em1(IMPC)Mbp
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge UC Davis | IMPC 5.65E-7
Ccnd2
Ccnd2tm1b(KOMP)Mbp
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 7.48E-7
Tulp3
Tulp3tm1b(EUCOMM)Hmgu
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 8.23E-7
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 1.08E-6
Slc6a2
Slc6a2tm1b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 1.2E-6
Pla2g16
Pla2g16em1(IMPC)Tcp
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve TCP | IMPC 1.54E-6
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 2.55E-6
Il10rb
Il10rbtm1a(KOMP)Wtsi
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge WTSI | IMPC 3.45E-6
Slc2a13
Slc2a13em1(IMPC)Mbp
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 3.48E-6
Kcnj11
Kcnj11tm1b(EUCOMM)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 3.48E-6
Pomc
Pomcem1(IMPC)Rbrc
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve RBRC | IMPC 6.32E-6
Farsa
Farsatm2a(EUCOMM)Wtsi
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge WTSI | IMPC 6.57E-6
Aqp1
Aqp1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 6.68E-6
Kcnc3
Kcnc3em1(IMPC)J
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve JAX | IMPC 7.07E-6
Rfx6
Rfx6tm1.1(KOMP)Vlcg
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 7.63E-6
Pkn3
Pkn3tm1.1(KOMP)Vlcg
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge JAX | IMPC 9.53E-6
Ggps1
Ggps1tm1b(EUCOMM)Wtsi
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve HMGU | IMPC 1.08E-5
Gtf2h2
Gtf2h2tm1a(EUCOMM)Wtsi
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve WTSI | IMPC 1.21E-5
Nisch
Nischtm1b(EUCOMM)Hmgu
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 1.33E-5
Ccdc151
Ccdc151tm1b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve HMGU | IMPC 1.37E-5
Ryr1
Ryr1tm1b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 1.62E-5
Nrxn1
Nrxn1tm1b(KOMP)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 1.66E-5
Commd9
Commd9tm1b(KOMP)Wtsi
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 2.13E-5
Dpm2
Dpm2tm1b(EUCOMM)Hmgu
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 2.24E-5
Spatc1l
Spatc1lem1(IMPC)H
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 2.48E-5
Cpe
Cpetm1b(EUCOMM)Hmgu
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve HMGU | IMPC 2.53E-5
Atp1a4
Atp1a4tm1b(KOMP)Wtsi
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 2.57E-5
Cib1
Cib1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 2.66E-5
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge WTSI | IMPC 3.14E-5
Cpgi15497
Cpgi15497tm1.1(NCC)WCS
HOM Female postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge WTSI | IMPC 3.21E-5
Zbtb43
Zbtb43tm1b(KOMP)Mbp
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve JAX | IMPC 3.4E-5
Pkd2l2
Pkd2l2tm1b(EUCOMM)Wtsi
HOM Female postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 3.48E-5
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge HMGU | IMPC 3.67E-5
Poc1a
Poc1atm1.1(KOMP)Mbp
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge JAX | IMPC 5.25E-5
Apoc4
Apoc4tm1.1(KOMP)Mbp
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge HMGU | IMPC 5.45E-5
Sec63
Sec63tm1b(EUCOMM)Hmgu
HET Female postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 5.63E-5
Fer1l4
Fer1l4tm1b(EUCOMM)Hmgu
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge MRC Harwell | IMPC 6.36E-5
Pgbd5
Pgbd5em1(IMPC)Tcp
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve TCP | IMPC 6.58E-5
Nsd3
Nsd3tm1b(EUCOMM)Hmgu
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 6.66E-5
Csmd1
Csmd1em1(IMPC)Wtsi
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve WTSI | IMPC 6.89E-5
Pycr1
Pycr1tm1.1(KOMP)Vlcg
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge JAX | IMPC 7.73E-5
Efr3b
Efr3bem1(IMPC)Mbp
HOM Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge UC Davis | IMPC 7.82E-5
Caskin1
Caskin1em1(IMPC)Mbp
HOM Female postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 8.1E-5
Shh
Shhtm1b(EUCOMM)Wtsi
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve MRC Harwell | IMPC 8.26E-5
Gpr15
Gpr15em1(IMPC)J
HOM Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve JAX | IMPC 9.43E-5
Dennd4c
Dennd4ctm1b(EUCOMM)Wtsi
HET Female Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Initial response to glucose challenge WTSI | IMPC 9.62E-5
Bmi1
Bmi1tm1.1(KOMP)Vlcg
HET Male postnatal impaired glucose tolerance Intraperitoneal glucose tolerance test (IPGTT) | Area under glucose response curve UC Davis | IMPC 9.67E-5

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