Phenotype: thrombocytopenia

Definition fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation

Synonyms
  • reduced platelet count
  • reduced platelet count
  • thrombopenia
  • thrombopenia
  • decreased thrombocyte number
  • decreased platelet cell number
  • decreased platelet count
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Related
Synonyms
  • Aplastic anemia
  • Aplastic anemia
  • absence of platelets
  • absence of platelets
  • absent platelets
  • absent thrombocytes
  • pancytopenia
Show more

MP browserMP:0003179

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Phenotype associations stats

1.66% of tested genes with null mutations on a B6N genetic background have a phenotype association to thrombocytopenia (57/3443)

1.11% females (38/3418) 1.63% males (56/3440)

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Gene variants with thrombocytopenia

Total number of significant genotype-phenotype associations: 101

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Irf8
Irf8tm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 1.72E-31
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 4.44E-21
Osm
Osmtm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 1.96E-19
Lyn
Lyntm1b(EUCOMM)Hmgu
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 6.76E-16
Nbeal2
Nbeal2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 1.07E-14
Knstrn
Knstrntm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count ICS | IMPC 2.63E-13
Emc10
Emc10tm1b(EUCOMM)Wtsi
HOM Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 4.54E-12
Crlf3
Crlf3tm1a(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Haematology test | Platelets-count WTSI | MGP 6.17E-12
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 2.22E-11
Crlf3
Crlf3tm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 4.82E-11
Txnip
Txniptm1b(EUCOMM)Hmgu
HOM Female postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 5.26E-11
Fbxo11
Fbxo11Jf
HET Female Male postnatal thrombocytopenia Haematology | Platelets count MRC Harwell | EuroPhenome 8.24E-11
Sept5
Sept5tm1b(EUCOMM)Hmgu
HET Female Male postnatal thrombocytopenia Hematology | Platelet count RBRC | IMPC 9.61E-11
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MARC | IMPC 8.58E-10
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 5.23E-9
Sgms1
Sgms1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 5.72E-9
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 6.12E-9
Pld3
Pld3tm1e(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 1.03E-8
Elmod1
Elmod1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal thrombocytopenia Haematology | Platelets count MRC Harwell | EuroPhenome 1.43E-8
Bcl3
Bcl3tm1b(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 1.64E-8
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 2.52E-8
Usp38
Usp38tm1b(EUCOMM)Hmgu
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 1.51E-7
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 3.34E-7
Mllt3
Mllt3tm1b(EUCOMM)Hmgu
HET Female Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 7.08E-7
Aspm
Aspmtm1a(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 1.07E-6
Ephx1
Ephx1
HOM Male postnatal thrombocytopenia Haematology | Platelets count ICS | EuroPhenome 1.23E-6
Acsl4
Acsl4tm1a(EUCOMM)Wtsi
HEM Male postnatal thrombocytopenia Haematology test | Platelets-count WTSI | MGP 1.49E-6
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Male postnatal thrombocytopenia Hematology | Platelet count HMGU | IMPC 1.76E-6
Gp9
Gp9tm1.1(KOMP)Vlcg
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count UC Davis | IMPC 1.86E-6
Arrb1
Arrb1tm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 2.19E-6
Smurf2
Smurf2tm1b(EUCOMM)Wtsi
HET Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 3.32E-6
Hsf2bp
Hsf2bptm1a(EUCOMM)Hmgu
HET Male postnatal thrombocytopenia Haematology | Platelets count HMGU | EuroPhenome 3.52E-6
Clpp
Clpptm1a(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 4.1E-6
Cfi
Cfitm1b(EUCOMM)Hmgu
HOM Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 4.72E-6
Acsl4
Acsl4tm1a(EUCOMM)Wtsi
HET Female postnatal thrombocytopenia Haematology test | Platelets-count WTSI | MGP 5.52E-6
Setdb2
Setdb2tm1a(KOMP)Wtsi
HOM Male postnatal thrombocytopenia Haematology | Platelets count HMGU | EuroPhenome 6.97E-6
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Male postnatal thrombocytopenia Hematology | Platelet count MRC Harwell | IMPC 9.61E-6
Ikzf3
Ikzf3tm1(KOMP)Vlcg
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count RBRC | IMPC 1.01E-5
Epc2
Epc2tm1a(EUCOMM)Wtsi
HOM Male postnatal thrombocytopenia Haematology | Platelets count HMGU | EuroPhenome 1.23E-5
Lsm14a
Lsm14atm1b(KOMP)Wtsi
HET Male postnatal thrombocytopenia Hematology | Platelet count MARC | IMPC 1.23E-5
Gp1bb
Gp1bbtm1.1(KOMP)Vlcg
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count UC Davis | IMPC 1.31E-5
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count UC Davis | IMPC 1.32E-5
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HET Female Male postnatal thrombocytopenia Hematology | Platelet count UC Davis | IMPC 1.32E-5
Dennd2d
Dennd2dtm2b(KOMP)Mbp
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 1.33E-5
Lamc3
Lamc3tm1a(KOMP)Wtsi
HOM Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 1.61E-5
Cyp3a59
Cyp3a59em1Marc
HET Female Male postnatal thrombocytopenia Hematology | Platelet count MARC | IMPC 1.82E-5
Rwdd1
Rwdd1tm1b(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 1.97E-5
Baiap2
Baiap2tm1b(KOMP)Wtsi
HET Male postnatal thrombocytopenia Hematology | Platelet count UC Davis | IMPC 3.04E-5
Ppp2r2b
Ppp2r2btm1a(KOMP)Wtsi
HOM Female Male postnatal thrombocytopenia Haematology test | Platelets-count WTSI | MGP 3.61E-5
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 3.86E-5
Phtf2
Phtf2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count WTSI | IMPC 4.61E-5
Mta1
Mta1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal thrombocytopenia Haematology | Platelets count WTSI | EuroPhenome 4.97E-5
Arrb2
Arrb2tm1.1(KOMP)Vlcg
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count JAX | IMPC 5.0E-5
Psph
Psphtm1.1(KOMP)Vlcg
HET Male postnatal thrombocytopenia Hematology | Platelet count TCP | IMPC 5.26E-5
Cidec
Cidectm1a(EUCOMM)Wtsi
HOM Male postnatal thrombocytopenia Haematology | Platelets count HMGU | EuroPhenome 6.2E-5
Usp42
Usp42tm2a(EUCOMM)Wtsi
HOM Male postnatal thrombocytopenia Haematology test | Platelets-count WTSI | MGP 7.6E-5
Cdan1
Cdan1tm1b(KOMP)Wtsi
HET Male postnatal thrombocytopenia Hematology | Platelet count UC Davis | IMPC 9.1E-5
Cox20
Cox20em1Tcp
HET Male postnatal thrombocytopenia Hematology | Platelet count TCP | IMPC 9.39E-5
Cadm1
Cadm1tm1.2Brd
HET Female Male postnatal thrombocytopenia Haematology | Platelets count WTSI | EuroPhenome 9.45E-5
Cadm1
Cadm1tm1.2Brd
HOM Female Male postnatal thrombocytopenia Haematology | Platelets count WTSI | EuroPhenome 9.45E-5
Fntb
Fntbtm1b(EUCOMM)Hmgu
HET Female Male postnatal thrombocytopenia Hematology | Platelet count MARC | IMPC 9.75E-5
Atg4b
Atg4bem1Marc
HOM Female Male postnatal thrombocytopenia Hematology | Platelet count MARC | IMPC 9.97E-5

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