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iMITs serves mouse production facilities from around the world as part of its funded mission to support the KOMP2 project; a NIH Common fund project to generate and phenotype 2500 knockout mouse strains in the next five years (1U54HG006370).
Mouse production and phenotype centers in the KOMP2 project are required to track mouse production through iMITS to minimize overlap and maximize efficiencies. KOMP2 production is coordinated with other mouse production centers through participation in the International Mouse Phenotyping Consortium (IMPC) whose goal is to generate a knockout mouse strain for every protein-coding gene in the mouse genome in the next 10 years.
To ensure a common genetic background, IMPC partners use the targeted ES cells generated by the International Knockout Mouse consortium (IKMC).
The majority of IMPC production centers use iMITs to track production to help prevent duplicate strain production and identify how their progress compares to other centers.