Histopathology IMPC_HIS_003

Jump to:

Purpose

To perform histopathological examination and annotation of the IMPC’s standard list of organs (see IMPReSS Gross Pathology & Tissue Collection) on stained tissue sections oriented on glass slides (see IMPReSS Tissue Embedding & Block Banking).

Experimental Design

 

Notes

Significance Score

Not significant. Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).

OR

Significant. Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Severity Score

Score

Term

Definition

0

Normal

No lesion(s) or abnormalities detectable considering the age and sex of the animal

1

Mild

Abnormality visible, involving single or multiple tissue types in a minimal proportion of an organ, likely to have no functional consequence

2

Moderate

Abnormality visible, involving multiple tissue types in a minority proportion of an organ, likely to have no clinical consequence (subclinical)

3

Marked

Abnormality clearly visible, involving multiple tissue types in a majority proportion of an organ, likely to have minor clinical manifestation(s)

4

Severe

Abnormality clearly visible, involving multiple tissue types in almost all visible area of an organ, likely to have major clinical manifestation(s)


Parameters & Metadata

Filter:

Name Version Type Description Req. Upload Req. Analysis Annotation Increment Options Ontology Options Unit Data Type Derived History Key Group
Name Version Type Description Req. Upload Req. Analysis Annotation Increment Option Ontology Options Unit Data Type Derived History Key Group