increased circulating cholesterol level

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Total cholesterolJAXSerpinb2tm1b(EUCOMM)WtsihomozygoteEarly adultJR287938.43x10-51.78x10-11.78x10-1

Serpinb2 data charts

Total cholesterol
Combination tested with the lowest p-value of 8.43x10-5
Experiments performed

A Clinical Chemistry phenotypic assay was performed on 2924 mice. The charts show the results of measuring Total cholesterol in 5 female, 6 male mutants compared to 1486 female, 1427 male controls. The mutants are for the Serpinb2tm1b(EUCOMM)Wtsi allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Total cholesterol
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NJ
Phenotyping center
JAX

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Total cholesterol / Box plot
Total cholesterol / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 1.78x10-1
Genotype parameter estimate 6.549
Genotype standard error estimate 5.034
Genotype Effect P Value 1.78x10-1
Sex Parameter Estimate 6.549
Sex Standard Error Estimate 0.985
Sex Effect P Value 1.78x10-1
Intercept Estimate 41.424
Intercept Estimate Standard Error 2.958
Sex Male KO P Value 1.78x10-1
Sex Female KO P Value 1.78x10-1
WT Residuals Normality Tests 8.19x10-8
KO Residuals Normality Tests 5.93x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 3.997
Bandwidth (l)564

Experimental data download

Download data as:  

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