increased circulating HDL cholesterol level

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
HDL-cholesterolJAXSerpinb2tm1b(EUCOMM)WtsihomozygoteEarly adultJR287938.66x10-51.75x10-11.75x10-1

Serpinb2 data charts

HDL-cholesterol
Combination tested with the lowest p-value of 8.66x10-5
Experiments performed

A Clinical Chemistry phenotypic assay was performed on 2943 mice. The charts show the results of measuring HDL-cholesterol in 5 female, 6 male mutants compared to 1489 female, 1443 male controls. The mutants are for the Serpinb2tm1b(EUCOMM)Wtsi allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
HDL-cholesterol
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NJ
Phenotyping center
JAX

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

HDL-cholesterol / Box plot
HDL-cholesterol / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 1.75x10-1
Genotype parameter estimate 8.186
Genotype standard error estimate 3.748
Genotype Effect P Value 1.75x10-1
Sex Parameter Estimate 8.186
Sex Standard Error Estimate 0.852
Sex Effect P Value 1.75x10-1
Intercept Estimate 30.421
Intercept Estimate Standard Error 2.582
Sex Male KO P Value 1.75x10-1
Sex Female KO P Value 1.75x10-1
WT Residuals Normality Tests 3.01x10-6
KO Residuals Normality Tests 1.53x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 1.503
Bandwidth (l)451

Experimental data download

Download data as:  

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