A Clinical Chemistry phenotypic assay was performed on 2943 mice. The charts show the results of measuring HDL-cholesterol in 5 female, 6 male mutants compared to 1489 female, 1443 male controls. The mutants are for the Serpinb2tm1b(EUCOMM)Wtsi allele.
increased circulating HDL cholesterol level
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
HDL-cholesterol | JAX | Serpinb2tm1b(EUCOMM)Wtsi | homozygote | Early adult | JR28793 | 8.66x10-5 | 1.75x10-1 | 1.75x10-1 |
Serpinb2 data charts
HDL-cholesterolExperiments performed
Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
HDL-cholesterol
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NJ
Phenotyping center
JAX
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
HDL-cholesterol / Box plot
HDL-cholesterol / Scatter plot
Results of statistical analysis
Genotype P value
1.75x10-1
Genotype*Female P value
1.75x10-1
Genotype*Male P value
8.66x10-5
Classification
With phenotype threshold value 1e-04 - Significant for males only
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 1.75x10-1 |
Genotype parameter estimate | 8.186 |
Genotype standard error estimate | 3.748 |
Genotype Effect P Value | 1.75x10-1 |
Sex Parameter Estimate | 8.186 |
Sex Standard Error Estimate | 0.852 |
Sex Effect P Value | 1.75x10-1 |
Intercept Estimate | 30.421 |
Intercept Estimate Standard Error | 2.582 |
Sex Male KO P Value | 1.75x10-1 |
Sex Female KO P Value | 1.75x10-1 |
WT Residuals Normality Tests | 3.01x10-6 |
KO Residuals Normality Tests | 1.53x10-1 |
Statistical analysis API access
Experimental data download
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