increased grip strength

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Forelimb grip strength normalised against body weightMRC HarwellNotch1tm1b(EUCOMM)HmguheterozygoteEarly adultH-NOTCH1-B12-TM1B3.3x10-57.05x10-17.05x10-1

Notch1 data charts

Forelimb grip strength normalised against body weight
Combination tested with the lowest p-value of 3.3x10-5
Experiments performed

A Grip Strength phenotypic assay was performed on 5516 mice. The charts show the results of measuring Forelimb grip strength normalised against body weight in 8 female, 8 male mutants compared to 2747 female, 2753 male controls. The mutants are for the Notch1tm1b(EUCOMM)Hmgu allele.

Associated phenotype
Zygosity
heterozygote
Testing protocol
Measured value
Forelimb grip strength normalised against body weight
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
MRC Harwell

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Forelimb grip strength normalised against body weight / Box plot
Forelimb grip strength normalised against body weight / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 7.05x10-1
Genotype parameter estimate -0.200
Genotype standard error estimate 0.174
Genotype Effect P Value 7.05x10-1
Sex Parameter Estimate -0.200
Sex Standard Error Estimate 0.034
Sex Effect P Value 7.05x10-1
Intercept Estimate 2.351
Intercept Estimate Standard Error 0.055
Sex Male KO P Value 7.05x10-1
Sex Female KO P Value 7.05x10-1
WT Residuals Normality Tests 8.64x10-10
KO Residuals Normality Tests 6.15x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 1.107
Bandwidth (l)188

Experimental data download

Download data as:  

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